Rudolf Uher

2018

Gene-environment interplay in the etiology of psychosis

Zwicker, A., Denovan-Wright, E. M. & Uher, R., Sept 1 2018, In: Psychological Medicine. 48, 12, p. 1925-1936 12 p.

Research output: Contribution to journal › Article › peer-review

Genes associated with anhedonia: a new analysis in a large clinical trial (GENDEP)

Ren, H., Fabbri, C., Uher, R., Rietschel, M., Mors, O., Henigsberg, N., Hauser, J., Zobel, A., Maier, W., Dernovsek, M. Z., Souery, D., Cattaneo, A., Breen, G., Craig, I. W., Farmer, A. E., McGuffin, P., Lewis, C. M. & Aitchison, K. J., Dec 1 2018, In: Translational Psychiatry. 8, 1, 150.

Research output: Contribution to journal › Article › peer-review

Open Access

18 Citations (Scopus)

Genetic disposition to inflammation and response to antidepressants in major depressive disorder

Zwicker, A., Fabbri, C., Rietschel, M., Hauser, J., Mors, O., Maier, W., Zobel, A., Farmer, A., Aitchison, K. J., McGuffin, P., Lewis, C. M. & Uher, R., Oct 2018, In: Journal of Psychiatric Research. 105, p. 17-22 6 p.

Research output: Contribution to journal › Article › peer-review

23 Citations (Scopus)

Genome Analyses of >200,000 Individuals Identify 58 Loci for Chronic Inflammation and Highlight Pathways that Link Inflammation and Complex Disorders

LifeLines Cohort Study & CHARGE Inflammation Working Group, Nov 1 2018, In: American Journal of Human Genetics. 103, 5, p. 691-706 16 p.

Research output: Contribution to journal › Article › peer-review

Open Access

306 Citations (Scopus)

Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression

Wray, N. R., Ripke, S., Mattheisen, M., Trzaskowski, M., Byrne, E. M., Abdellaoui, A., Adams, M. J., Agerbo, E., Air, T. M., Andlauer, T. M. F., Bacanu, S. A., Bækvad-Hansen, M., Beekman, A. F. T., Bigdeli, T. B., Binder, E. B., Blackwood, D. R. H., Bryois, J., Buttenschøn, H. N., Bybjerg-Grauholm, J., Cai, N., & 196 othersCastelao, E., Christensen, J. H., Clarke, T. K., Coleman, J. I. R., Colodro-Conde, L., Couvy-Duchesne, B., Craddock, N., Crawford, G. E., Crowley, C. A., Dashti, H. S., Davies, G., Deary, I. J., Degenhardt, F., Derks, E. M., DIrek, N., Dolan, C. V., Dunn, E. C., Eley, T. C., Eriksson, N., Escott-Price, V., Kiadeh, F. H. F., Finucane, H. K., Forstner, A. J., Frank, J., Gaspar, H. A., Gill, M., Giusti-Rodríguez, P., Goes, F. S., Gordon, S. D., Grove, J., Hall, L. S., Hannon, E., Hansen, C. S., Hansen, T. F., Herms, S., Hickie, I. B., Hoffmann, P., Homuth, G., Horn, C., Hottenga, J. J., Hougaard, D. M., Hu, M., Hyde, C. L., Ising, M., Jansen, R., Jin, F., Jorgenson, E., Knowles, J. A., Kohane, I. S., Kraft, J., Kretzschmar, W. W., Krogh, J., Kutalik, Z., Lane, J. M., Li, Y., Li, Y., Lind, P. A., Liu, X., Lu, L., MacIntyre, D. J., MacKinnon, D. F., Maier, R. M., Maier, W., Marchini, J., Mbarek, H., McGrath, P., McGuffin, P., Medland, S. E., Mehta, DI., Middeldorp, C. M., Mihailov, E., Milaneschi, Y., Milani, L., Mill, J., Mondimore, F. M., Montgomery, G. W., Mostafavi, S., Mullins, N., Nauck, M., Ng, B., Nivard, M. G., Nyholt, D. R., O'Reilly, P. F., Oskarsson, H., Owen, M. J., Painter, J. N., Pedersen, C. B., Pedersen, M. G., Peterson, R. E., Pettersson, E., Peyrot, W. J., Pistis, G., Posthuma, D., Purcell, S. M., Quiroz, J. A., Qvist, P., Rice, J. P., Riley, B. P., Rivera, M., Saeed Mirza, S., Saxena, R., Schoevers, R., Schulte, E. C., Shen, L., Shi, J., Shyn, S. I., Sigurdsson, E., Sinnamon, G. B. C., Smit, J. H., Smith, D. J., Stefansson, H., Steinberg, S., Stockmeier, C. A., Streit, F., Strohmaier, J., Tansey, K. E., Teismann, H., Teumer, A., Thompson, W., Thomson, P. A., Thorgeirsson, T. E., Tian, C., Traylor, M., Treutlein, J., Trubetskoy, V., Uitterlinden, A. G., Umbricht, D., Van Der Auwera, S., Van Hemert, A. M., Viktorin, A., Visscher, P. M., Wang, Y., Webb, B. T., Weinsheimer, S. M., Wellmann, J., Willemsen, G., Witt, S. H., Wu, Y., Xi, H. S., Yang, J., Zhang, F., Arolt, V., Baune, B. T., Berger, K., Boomsma, D. I., Cichon, S., Dannlowski, U., De Geus, E. C. J., Depaulo, J. R., Domenici, E., Domschke, K., Esko, T., Grabe, H. J., Hamilton, S. P., Hayward, C., Heath, A. C., Hinds, D. A., Kendler, K. S., Kloiber, S., Lewis, G., Li, Q. S., Lucae, S., Madden, P. F. A., Magnusson, P. K., Martin, N. G., McIntosh, A. M., Metspalu, A., Mors, O., Mortensen, P. B., Müller-Myhsok, B., Nordentoft, M., Nöthen, M. M., O'Donovan, M. C., Paciga, S. A., Pedersen, N. L., Penninx, B. W. J. H., Perlis, R. H., Porteous, D. J., Potash, J. B., Preisig, M., Rietschel, M., Schaefer, C., Schulze, T. G., Smoller, J. W., Stefansson, K., Tiemeier, H., Uher, R., Völzke, H., Weissman, M. M., Werge, T., Winslow, A. R., Lewis, C. M., Levinson, D. F., Breen, G., Børglum, A. D. & Sullivan, P. F., May 1 2018, In: Nature Genetics. 50, 5, p. 668-681 14 p.

Research output: Contribution to journal › Article › peer-review

1988 Citations (Scopus)

Genome-wide interaction study of a proxy for stress-sensitivity and its prediction of major depressive disorder

Generation Scotland & Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, Dec 2018, In: PLoS One. 13, 12, e0209160.

Research output: Contribution to journal › Article › peer-review

Open Access

16 Citations (Scopus)

Interaction between childhood maltreatment on immunogenetic risk in depression: Discovery and replication in clinical case-control samples

Cohen-Woods, S., Fisher, H. L., Ahmetspahic, D., Douroudis, K., Stacey, D., Hosang, G. M., Korszun, A., Owen, M., Craddock, N., Arolt, V., Dannowski, U., Breen, G., Craig, I. W., Farmer, A., Baune, B. T., Lewis, C. M., Uher, R. & McGuffin, P., Jan 1 2018, In: Brain, Behavior, and Immunity. 67, p. 203-210 8 p.

Medicine

Research output: Contribution to journal › Article › peer-review

30 Citations (Scopus)

New insights into the pharmacogenomics of antidepressant response from the GENDEP and STAR∗D studies: Rare variant analysis and high-density imputation

Fabbri, C., Tansey, K. E., Perlis, R. H., Hauser, J., Henigsberg, N., Maier, W., Mors, O., Placentino, A., Rietschel, M., Souery, D., Breen, G., Curtis, C., Sang-Hyuk, L., Newhouse, S., Patel, H., Guipponi, M., Perroud, N., Bondolfi, G., O'Donovan, M., Lewis, G., & 8 othersBiernacka, J. M., Weinshilboum, R. M., Farmer, A., Aitchison, K. J., Craig, I., McGuffin, P., Uher, R. & Lewis, C. M., May 22 2018, In: Pharmacogenomics Journal. 18, 3, p. 413-421 9 p.

Research output: Contribution to journal › Article › peer-review

37 Citations (Scopus)

No association between antidepressant efficacy and rs28365143 in corticotropin-releasing hormone binding protein in a large meta-analysis

Fabbri, C., Lewis, C. M., Perlis, R. H. & Uher, R., Jun 2018, In: American Journal of Psychiatry. 175, 6, p. 575-576 2 p.

Medicine

Research output: Contribution to journal › Letter › peer-review

Open Access

1 Citation (Scopus)

Obesity, dyslipidemia and brain age in first-episode psychosis

Kolenic, M., Franke, K., Hlinka, J., Matejka, M., Capkova, J., Pausova, Z., Uher, R., Alda, M., Spaniel, F. & Hajek, T., Apr 2018, In: Journal of Psychiatric Research. 99, p. 151-158 8 p.

Research output: Contribution to journal › Article › peer-review

72 Citations (Scopus)

Polygenic risk scores for major depressive disorder and neuroticism as predictors of antidepressant response: Meta-analysis of three treatment cohorts

Ward, J., Graham, N., Strawbridge, R. J., Ferguson, A., Jenkins, G., Chen, W., Hodgson, K., Frye, M., Weinshilboum, R., Uher, R., Lewis, C. M., Biernacka, J. & Smith, D. J., Sept 2018, In: PLoS One. 13, 9, e0203896.

Research output: Contribution to journal › Article › peer-review

Open Access

45 Citations (Scopus)

Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity

Turcot, V., Lu, Y., Highland, H. M., Schurmann, C., Justice, A. E., Fine, R. S., Bradfield, J. P., Esko, T., Giri, A., Graff, M., Guo, X., Hendricks, A. E., Karaderi, T., Lempradl, A., Locke, A. E., Mahajan, A., Marouli, E., Sivapalaratnam, S., Young, K. L., Alfred, T., & 379 othersFeitosa, M. F., Masca, N. G. D., Manning, A. K., Medina-Gomez, C., Mudgal, P., Ng, M. C. Y., Reiner, A. P., Vedantam, S., Willems, S. M., Winkler, T. W., Abecasis, G., Aben, K. K., Alam, D. S., Alharthi, S. E., Allison, M., Amouyel, P., Asselbergs, F. W., Auer, P. L., Balkau, B., Bang, L. E., Barroso, I., Bastarache, L., Benn, M., Bergmann, S., Bielak, L. F., Blüher, M., Boehnke, M., Boeing, H., Boerwinkle, E., Böger, C. A., Bork-Jensen, J., Bots, M. L., Bottinger, E. P., Bowden, D. W., Brandslund, I., Breen, G., Brilliant, M. H., Broer, L., Brumat, M., Burt, A. A., Butterworth, A. S., Campbell, P. T., Cappellani, S., Carey, D. J., Catamo, E., Caulfield, M. J., Chambers, J. C., Chasman, D. I., Chen, Y. D. I., Chowdhury, R., Christensen, C., Chu, A. Y., Cocca, M., Cook, J. P., Corley, J., Corominas Galbany, J., Cox, A. J., Crosslin, D. S., Cuellar-Partida, G., D'Eustacchio, A., Danesh, J., Davies, G., Bakker, P. I. W., Groot, M. C. H., Mutsert, R., Deary, I. J., Dedoussis, G., Demerath, E. W., Heijer, M., Hollander, A. I., Ruijter, H. M., Dennis, J. G., Denny, J. C., Angelantonio, E., Drenos, F., Du, M., Dubé, M. P., Dunning, A. M., Easton, D. F., Edwards, T. L., Ellinghaus, D., Ellinor, P. T., Elliott, P., Evangelou, E., Farmaki, A. E., Farooqi, I. S., Faul, J. D., Fauser, S., Feng, S., Ferrannini, E., Ferrieres, J., Florez, J. C., Ford, I., Fornage, M., Franco, O. H., Franke, A., Franks, P. W., Friedrich, N., Frikke-Schmidt, R., Galesloot, T. E., Gan, W., Gandin, I., Gasparini, P., Gibson, J., Giedraitis, V., Gjesing, A. P., Gordon-Larsen, P., Gorski, M., Grabe, H. J., Grant, S. F. A., Grarup, N., Griffiths, H. L., Grove, M. L., Gudnason, V., Gustafsson, S., Haessler, J., Hakonarson, H., Hammerschlag, A. R., Hansen, T., Harris, K. M., Harris, T. B., Hattersley, A. T., Have, C. T., Hayward, C., He, L., Heard-Costa, N. L., Heath, A. C., Heid, I. M., Helgeland, Ø., Hernesniemi, J., Hewitt, A. W., Holmen, O. L., Hovingh, G. K., Howson, J. M. M., Hu, Y., Huang, P. L., Huffman, J. E., Ikram, M. A., Ingelsson, E., Jackson, A. U., Jansson, J. H., Jarvik, G. P., Jensen, G. B., Jia, Y., Johansson, S., Jørgensen, M. E., Jørgensen, T., Jukema, J. W., Kahali, B., Kahn, R. S., Kähönen, M., Kamstrup, P. R., Kanoni, S., Kaprio, J., Karaleftheri, M., Kardia, S. L. R., Karpe, F., Kathiresan, S., Kee, F., Kiemeney, L. A., Kim, E., Kitajima, H., Komulainen, P., Kooner, J. S., Kooperberg, C., Korhonen, T., Kovacs, P., Kuivaniemi, H., Kutalik, Z., Kuulasmaa, K., Kuusisto, J., Laakso, M., Lakka, T. A., Lamparter, D., Lange, E. M., Lange, L. A., Langenberg, C., Larson, E. B., Lee, N. R., Lehtimäki, T., Lewis, C. E., Li, H., Li, J., Li-Gao, R., Lin, H., Lin, K. H., Lin, L. A., Lin, X., Lind, L., Lindström, J., Linneberg, A., Liu, C. T., Liu, D. J., Liu, Y., Lo, K. S., Lophatananon, A., Lotery, A. J., Loukola, A., Luan, JA., Lubitz, S. A., Lyytikäinen, L. P., Männistö, S., Marenne, G., Mazul, A. L., McCarthy, M. I., McKean-Cowdin, R., Medland, S. E., Meidtner, K., Milani, L., Mistry, V., Mitchell, P., Mohlke, K. L., Moilanen, L., Moitry, M., Montgomery, G. W., Mook-Kanamori, D. O., Moore, C., Mori, T. A., Morris, A. D., Morris, A. P., Müller-Nurasyid, M., Munroe, P. B., Nalls, M. A., Narisu, N., Nelson, C. P., Neville, M., Nielsen, S. F., Nikus, K., Njølstad, P. R., Nordestgaard, B. G., Nyholt, D. R., O'Connel, J. R., O'Donoghue, M. L., Olde Loohuis, L. M., Ophoff, R. A., Owen, K. R., Packard, C. J., Padmanabhan, S., Palmer, C. N. A., Palmer, N. D., Pasterkamp, G., Patel, A. P., Pattie, A., Pedersen, O., Peissig, P. L., Peloso, G. M., Pennell, C. E., Perola, M., Perry, J. A., Perry, J. R. B., Pers, T. H., Person, T. N., Peters, A., Petersen, E. R. B., Peyser, P. A., Pirie, A., Polasek, O., Polderman, T. J., Puolijoki, H., Raitakari, O. T., Rasheed, A., Rauramaa, R., Reilly, D. F., Renström, F., Rheinberger, M., Ridker, P. M., Rioux, J. D., Rivas, M. A., Roberts, D. J., Robertson, N. R., Robino, A., Rolandsson, O., Rudan, I., Ruth, K. S., Saleheen, D., Salomaa, V., Samani, N. J., Sapkota, Y., Sattar, N., Schoen, R. E., Schreiner, P. J., Schulze, M. B., Scott, R. A., Segura-Lepe, M. P., Shah, S. H., Sheu, W. H. H., Sim, X., Slater, A. J., Small, K. S., Smith, A. V., Southam, L., Spector, T. D., Speliotes, E. K., Starr, J. M., Stefansson, K., Steinthorsdottir, V., Stirrups, K. E., Strauch, K., Stringham, H. M., Stumvoll, M., Sun, L., Surendran, P., Swift, A. J., Tada, H., Tansey, K. E., Tardif, J. C., Taylor, K. D., Teumer, A., Thompson, D. J., Thorleifsson, G., Thorsteinsdottir, U., Thuesen, B. H., Tönjes, A., Tromp, G., Trompet, S., Tsafantakis, E., Tuomilehto, J., Tybjaerg-Hansen, A., Tyrer, J. P., Uher, R., Uitterlinden, A. G., Uusitupa, M., Laan, S. W., Duijn, C. M., Leeuwen, N., Van Setten, J., Vanhala, M., Varbo, A., Varga, T. V., Varma, R., Velez Edwards, D. R., Vermeulen, S. H., Veronesi, G., Vestergaard, H., Vitart, V., Vogt, T. F., Völker, U., Vuckovic, D., Wagenknecht, L. E., Walker, M., Wallentin, L., Wang, F., Wang, C. A., Wang, S., Wang, Y., Ware, E. B., Wareham, N. J., Warren, H. R., Waterworth, D. M., Wessel, J., White, H. D., Willer, C. J., Wilson, J. G., Witte, D. R., Wood, A. R., Wu, Y., Yaghootkar, H., Yao, J., Yao, P., Yerges-Armstrong, L. M., Young, R., Zeggini, E., Zhan, X., Zhang, W., Zhao, J. H., Zhao, W., Zhou, W., Zondervan, K. T., Rotter, J. I., Pospisilik, J. A., Rivadeneira, F., Borecki, I. B., Deloukas, P., Frayling, T. M., Lettre, G., North, K. E., Lindgren, C. M., Hirschhorn, J. N. & Loos, R. J. F., Jan 1 2018, In: Nature Genetics. 50, 1, p. 26-35 10 p.

Research output: Contribution to journal › Article › peer-review

285 Citations (Scopus)

Protocol for a scoping review to support development of a CONSORT extension for randomised controlled trials using cohorts and routinely collected health data

Kwakkenbos, L., Imran, M., McCord, K. A., Sampson, M., Fröbert, O., Gale, C., Hemkens, L. G., Langan, S. M., Moher, D., Relton, C., Zwarenstein, M., Benchimol, E. I., Boutron, I., Campbell, M. K., Erlinge, D., Jawad, S., Ravaud, P., Rice, D. B., Sauve, M., Van Staa, T. P., & 5 othersThabane, L., Uher, R., Verkooijen, H. M., Juszczak, E. & Thombs, B. D., Aug 1 2018, In: BMJ Open. 8, 8, e025266.

Medicine

Research output: Contribution to journal › Article › peer-review

Open Access

11 Citations (Scopus)

Psychological interventions in offspring of parents with bipolar disorder

Uher, R. & Pavlova, B., Jan 1 2018, Bipolar Disorder Vulnerability: Perspectives from Pediatric and High-Risk Populations. Elsevier, p. 247-264 18 p.

Medicine

Research output: Chapter in Book/Report/Conference proceeding › Chapter

2017

An Analysis of Two Genome-wide Association Meta-analyses Identifies a New Locus for Broad Depression Phenotype

Direk, N., Williams, S., Smith, J. A., Ripke, S., Air, T., Amare, A. T., Amin, N., Baune, B. T., Bennett, D. A., Blackwood, D. H. R., Boomsma, D., Breen, G., Buttenschøn, H. N., Byrne, E. M., Børglum, A. D., Castelao, E., Cichon, S., Clarke, T. K., Cornelis, M. C., Dannlowski, U., & 82 othersDe Jager, P. L., Demirkan, A., Domenici, E., van Duijn, C. M., Dunn, E. C., Eriksson, J. G., Esko, T., Faul, J. D., Ferrucci, L., Fornage, M., de Geus, E., Gill, M., Gordon, S. D., Grabe, H. J., van Grootheest, G., Hamilton, S. P., Hartman, C. A., Heath, A. C., Hek, K., Hofman, A., Homuth, G., Horn, C., Jan Hottenga, J., Kardia, S. L. R., Kloiber, S., Koenen, K., Kutalik, Z., Ladwig, K. H., Lahti, J., Levinson, D. F., Lewis, C. M., Lewis, G., Li, Q. S., Llewellyn, D. J., Lucae, S., Lunetta, K. L., MacIntyre, D. J., Madden, P., Martin, N. G., McIntosh, A. M., Metspalu, A., Milaneschi, Y., Montgomery, G. W., Mors, O., Mosley, T. H., Murabito, J. M., Müller-Myhsok, B., Nöthen, M. M., Nyholt, D. R., O'Donovan, M. C., Penninx, B. W., Pergadia, M. L., Perlis, R., Potash, J. B., Preisig, M., Purcell, S. M., Quiroz, J. A., Räikkönen, K., Rice, J. P., Rietschel, M., Rivera, M., Schulze, T. G., Shi, J., Shyn, S., Sinnamon, G. C., Smit, J. H., Smoller, J. W., Snieder, H., Tanaka, T., Tansey, K. E., Teumer, A., Uher, R., Umbricht, D., Van der Auwera, S., Ware, E. B., Weir, D. R., Weissman, M. M., Willemsen, G., Yang, J., Zhao, W., Tiemeier, H. & Sullivan, P. F., Sept 1 2017, In: Biological Psychiatry. 82, 5, p. 322-329 8 p.

Research output: Contribution to journal › Article › peer-review

60 Citations (Scopus)

Association between C-reactive protein (CRP) with depression symptom severity and specific depressive symptoms in major depression

Köhler-Forsberg, O., Buttenschøn, H. N., Tansey, K. E., Maier, W., Hauser, J., Dernovsek, M. Z., Henigsberg, N., Souery, D., Farmer, A., Rietschel, M., McGuffin, P., Aitchison, K. J., Uher, R. & Mors, O., May 1 2017, In: Brain, Behavior, and Immunity. 62, p. 344-350 7 p.

Research output: Contribution to journal › Article › peer-review

214 Citations (Scopus)

Association of antidepressant medication use during pregnancy with intellectual disability in offspring

Viktorin, A., Uher, R., Kolevzon, A., Reichenberg, A., Levine, S. Z. & Sandin, S., Oct 2017, In: JAMA Psychiatry. 74, 10, p. 1031-1038 8 p.

Research output: Contribution to journal › Article › peer-review

39 Citations (Scopus)

Autism risk following antidepressant medication during pregnancy

Viktorin, A., Uher, R., Reichenberg, A., Levine, S. Z. & Sandin, S., Dec 1 2017, In: Psychological Medicine. 47, 16, p. 2787-2796 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

50 Citations (Scopus)

Childhood maltreatment and the medical morbidity in bipolar disorder: a case–control study

Hosang, G. M., Fisher, H. L., Uher, R., Cohen-Woods, S., Maughan, B., McGuffin, P. & Farmer, A. E., Dec 1 2017, In: International Journal of Bipolar Disorders. 5, 1, 30.

Medicine

Research output: Contribution to journal › Article › peer-review

Open Access

13 Citations (Scopus)

Disruptive mood dysregulation disorder in offspring of parents with depression and bipolar disorder

Propper, L., Cumby, J., Patterson, V. C., Drobinin, V., Glover, J. M., MacKenzie, L. E., Morash-Conway, J., Abidi, S., Bagnell, A., Lovas, D., Hajek, T., Gardner, W., Pajer, K., Alda, M. & Uher, R., Jun 2017, In: British Journal of Psychiatry. 210, 6, p. 408-412 5 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

16 Citations (Scopus)

Etiology in psychiatry: embracing the reality of poly-gene-environmental causation of mental illness

Uher, R. & Zwicker, A., Jun 2017, In: World Psychiatry. 16, 2, p. 121-129 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

242 Citations (Scopus)

Genetic association of major depression with a typical features and obesity-related immunometabolic dysregulations

CHARGE InflammationWorking Group and the Major Depressive DisorderWorking Group of the Psychiatric Genomics Consortium, Dec 2017, In: JAMA Psychiatry. 74, 12, p. 1214-1225 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

165 Citations (Scopus)

Hair Cortisol in Twins: Heritability and Genetic Overlap with Psychological Variables and Stress-System Genes

Rietschel, L., Streit, F., Zhu, G., McAloney, K., Frank, J., Couvy-Duchesne, B., Witt, S. H., Binz, T. M., Bolton, J. L., Hayward, C., Direk, N., Anderson, A., Huffman, J., Wilson, J. F., Campbell, H., Rudan, I., Wright, A., Hastie, N., Wild, S. H., Velders, F. P., & 215 othersHofman, A., Uitterlinden, A. G., Lahti, J., Räikkönen, K., Kajantie, E., Widen, E., Palotie, A., Eriksson, J. G., Kaakinen, M., Järvelin, M. R., Timpson, N. J., Davey Smith, G., Ring, S. M., Evans, D. M., St Pourcain, B., Tanaka, T., Milaneschi, Y., Bandinelli, S., Ferrucci, L., Van Der Harst, P., Rosmalen, J. G., Bakker, S. J., Verweij, N., Dullaart, R. P., Mahajan, A., Lindgren, C. M., Morris, A., Lind, L., Ingelsson, E., Anderson, L. N., Pennell, C. E., Lye, S. J., Matthews, S. G., Eriksson, J., Mellstrom, D., Ohlsson, C., Price, J. F., Strachan, M. W., Reynolds, R. M., Tiemeier, H., Ripke, S., Mattheisen, M., Abdellaoui, A., Adams, M. J., Agerbo, E., Air, T. M., Andlauer, T. F., Bacanu, S. A., Bækvad-Hansen, M., Beekman, A. T., Bennett, D. A., Berger, K., Bigdeli, T. B., Bybjerg-Grauholm, J., Byrne, E. M., Cai, N., Castelao, E., Clarke, T. K., Coleman, J. R., Consortium, C., Craddock, N., Dannlowski, U., Davies, G., Davies, G., De Geus, E. J. C., De Jager, P., Deary, I. J., Degenhardt, F., Dunn, E. C., Ehli, E. A., Eley, T. C., Escott-Price, V., Esko, T., Finucane, H. K., Gill, M., Gordon, S. D., Grove, J., Hall, L. S., Hansen, T. F., Søholm Hansen, C., Heath, A. C., Henders, A. K., Herms, S., Hoffmann, P., Homuth, G., Horn, C., Hottenga, J. J., Hougaard, D., Huang, H., Ising, M., Jansen, R., Jorgenson, E., Kloiber, S., Knowles, J. A., Kretzschmar, W. W., Krogh, J., Kutalik, Z., Lang, M., Lewis, G., Li, Y., MacIntyre, D. J., Madden, P. A., Marchine, J., Mbarek, H., McGuffin, P., Mehta, D., Metspalu, A., Middeldorp, C. M., Mihailov, E., Milani, L., Montgomery, G. W., Mostafavi, S., Mullins, N., Nauck, M., Ng, B., Nordentoft, M., Nyholt, D. R., O'Donovan, M. C., O'Reilly, P. F., Oskarsson, H., Owen, M. J., Paciga, S. A., Pedersen, C. B., Pedersen, M. G., Pedersen, N. L., Pergadia, M. L., Peterson, R. E., Pettersson, E., Peyrot, W. J., Porteous, D. J., Posthuma, D., Potash, J. B., Quiroz, J. A., Rice, J. P., Riley, B. P., Rivera, M., Ruderfer, D. M., Saeed Mirza, S., Schoevers, R., Shen, L., Shi, J., Sigurdsson, E., Sinnamon, G. C., Smit, J. H., Smith, D. J., Stephansson, H., Steinberg, S., Strohmaier, J., Tansey, K. E., Teumer, A., Thompson, W., Thomson, P. A., Thorgeirsson, T. E., Treutlein, J., Trzaskowski, M., Umbricht, D., Van Der Auwera, S., Van Grootheest, G., Van Hemert, A. M., Viktorin, A., Völzke, H., Wang, Y., Webb, B. T., Weissman, M. M., Wellmann, J., Willemsen, G., Xi, H. S., Baune, B. T., Blackwood, D. H. R., Boomsma, D. I., Børglum, A. D., Buttenschøn, H. N., Cichon, S., Domenici, E., Flint, J., Grabe, H. J., Hamilton, S. P., Kendler, K. S., Li, Q. S., Lucae, S., Magnusson, P. K., McIntosh, A. M., Mors, O., Bo Mortensen, P., Müller-Myhsok, B., Penninx, B. W., Perlis, R. H., Preisig, M., Schaefer, C., Smoller, J. W., Stephansson, K., Uher, R., Werge, T., Winslow, A. R., Breen, G., Levinson, D. F., Lewis, C. M., Wray, N. R., Sullivan, P. F., McGrath, J., Hickie, I. B., Hansell, N. K., Wright, M. J., Gillespie, N. A., Forstner, A. J., Schulze, T. G., Wüst, S., Nöthen, M. M., Baumgartner, M. R., Walker, B. R., Crawford, A. A., Colodro-Conde, L., Medland, S. E., Martin, N. G. & Rietschel, M., Dec 1 2017, In: Scientific Reports. 7, 1, 15351.

Research output: Contribution to journal › Article › peer-review

Open Access

56 Citations (Scopus)

Highly polygenic architecture of antidepressant treatment response: Comparative analysis of SSRI and NRI treatment in an animal model of depression

Malki, K., Tosto, M. G., Mouriño-Talín, H., Rodríguez-Lorenzo, S., Pain, O., Jumhaboy, I., Liu, T., Parpas, P., Newman, S., Malykh, A., Carboni, L., Uher, R., McGuffin, P., Schalkwyk, L. C., Bryson, K. & Herbster, M., Apr 1 2017, In: American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics. 174, 3, p. 235-250 16 p.

Research output: Contribution to journal › Article › peer-review

Open Access

9 Citations (Scopus)

Hot and cold executive functions in youth with psychotic symptoms

MacKenzie, L. E., Patterson, V. C., Zwicker, A., Drobinin, V., Fisher, H. L., Abidi, S., Greve, A. N., Bagnell, A., Propper, L., Alda, M., Pavlova, B. & Uher, R., Dec 1 2017, In: Psychological Medicine. 47, 16, p. 2844-2853 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

20 Citations (Scopus)

Interaction between the FTO gene, body mass index and depression: Meta-analysis of 13701 individuals

Rivera, M., Locke, A. E., Corre, T., Czamara, D., Wolf, C., Ching-Lopez, A., Milaneschi, Y., Kloiber, S., Cohen-Woods, S., Rucker, J., Aitchison, K. J., Bergmann, S., Boomsma, D. I., Craddock, N., Gill, M., Holsboer, F., Hottenga, J. J., Korszun, A., Kutalik, Z., Lucae, S., & 18 othersMaier, W., Mors, O., Muller-Myhsok, B., Owen, M. J., Penninx, B. W. J. H., Preisig, M., Rice, J., Rietschel, M., Tozzi, F., Uher, R., Vollenweider, P., Waeber, G., Willemsen, G., Craig, I. W., Farmer, A. E., Lewis, C. M., Breen, G. & McGuffin, P., Aug 2017, In: British Journal of Psychiatry. 211, 2, p. 70-76 7 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

51 Citations (Scopus)

MicroRNAs 146a/b-5 and 425-3p and 24-3p are markers of antidepressant response and regulate MAPK/Wnt-system genes

Lopez, J. P., Fiori, L. M., Cruceanu, C., Lin, R., Labonte, B., Cates, H. M., Heller, E. A., Vialou, V., Ku, S. M., Gerald, C., Han, M. H., Foster, J., Frey, B. N., Soares, C. N., Müller, D. J., Farzan, F., Leri, F., Macqueen, G. M., Feilotter, H., Tyryshkin, K., & 16 othersEvans, K. R., Giacobbe, P., Blier, P., Lam, R. W., Milev, R., Parikh, S. V., Rotzinger, S., Strother, S. C., Lewis, C. M., Aitchison, K. J., Wittenberg, G. M., Mechawar, N., Nestler, E. J., Uher, R., Kennedy, S. H. & Turecki, G., May 22 2017, In: Nature Communications. 8, 15497.

Research output: Contribution to journal › Article › peer-review

Open Access

152 Citations (Scopus)

Pharmacogenetics of antidepressant response: A polygenic approach

García-González, J., Tansey, K. E., Hauser, J., Henigsberg, N., Maier, W., Mors, O., Placentino, A., Rietschel, M., Souery, D., Žagar, T., Czerski, P. M., Jerman, B., Buttenschøn, H. N., Schulze, T. G., Zobel, A., Farmer, A., Aitchison, K. J., Craig, I., McGuffin, P., Giupponi, M., & 21 othersPerroud, N., Bondolfi, G., Evans, D., O'Donovan, M., Peters, T. J., Wendland, J. R., Lewis, G., Kapur, S., Perlis, R., Arolt, V., Domschke, K., Breen, G., Curtis, C., Sang-Hyuk, L., Kan, C., Newhouse, S., Patel, H., Baune, B. T., Uher, R., Lewis, C. M. & Fabbri, C., Apr 3 2017, In: Progress in Neuro-Psychopharmacology and Biological Psychiatry. 75, p. 128-134 7 p.

Research output: Contribution to journal › Article › peer-review

71 Citations (Scopus)

Prevalence of current anxiety disorders in people with bipolar disorder during euthymia: A meta-analysis

Pavlova, B., Perlis, R. H., Mantere, O., Sellgren, C. M., Isometsä, E., Mitchell, P. B., Alda, M. & Uher, R., Apr 1 2017, In: Psychological Medicine. 47, 6, p. 1107-1115 9 p.

Research output: Contribution to journal › Article › peer-review

41 Citations (Scopus)

Rare and low-frequency coding variants alter human adult height

MAGIC Investigators, The EPIC-InterAct Consortium, EPIC-CVD Consortium, CHD Exome+ Consortium, ExomeBP Consortium, T2D-Genes Consortium, GoT2D Genes Consortium, Global Lipids Genetics Consortium & ReproGen Consortium, Feb 9 2017, In: Nature. 542, 7640, p. 186-190 5 p.

Research output: Contribution to journal › Article › peer-review

453 Citations (Scopus)

Rating Short-Term Psychodynamic Therapy for the Canadian Network for Mood and Anxiety Treatments Depression Guidelines: Key Considerations

Parikh, S. V., Quilty, L., Ravitz, P., Rosenbluth, M., Pavlova, B., Grigoriadis, S., Velyvis, V., Uher, R., Kennedy, S. H., Lam, R. W., Macqueen, G. M., Milev, R. & Ravindran, A. V., Jan 1 2017, In: Canadian Journal of Psychiatry. 62, 1, p. 77-78 2 p.

Research output: Contribution to journal › Letter › peer-review

Open Access

The Effect of Parental Modeling on Child Pain Responses: The Role of Parent and Child Sex

Boerner, K. E., Chambers, C. T., McGrath, P. J., LoLordo, V. & Uher, R., Jun 2017, In: Journal of Pain. 18, 6, p. 702-715 14 p.

Research output: Contribution to journal › Article › peer-review

35 Citations (Scopus)

The genome-wide expression effects of escitalopram and its relationship to neurogenesis, hippocampal volume, and antidepressant response

Powell, T. R., Murphy, T., de Jong, S., Lee, S. H., Tansey, K. E., Hodgson, K., Uher, R., Price, J., Thuret, S. & Breen, G., Jun 2017, In: American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics. 174, 4, p. 427-434 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

14 Citations (Scopus)

2016

Absolute measurements of macrophage migration inhibitory factor and interleukin-1-β mRNA levels accurately predict treatment response in depressed patients

Cattaneo, A., Ferrari, C., Uher, R., Bocchio-Chiavetto, L., Riva, M. A. & Pariante, C. M., Oct 2016, In: International Journal of Neuropsychopharmacology. 19, 10, p. 1-10 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

114 Citations (Scopus)

Canadian Network for Mood and Anxiety Treatments (CANMAT) 2016 clinical guidelines for the management of adults with major depressive disorder: Section 3. Pharmacological Treatments

Kennedy, S. H., Lam, R. W., McIntyre, R. S., Tourjman, S. V., Bhat, V., Blier, P., Hasnain, M., Jollant, F., Levitt, A. J., MacQueen, G. M., McInerney, S. J., McIntosh, D., Milev, R. V., Müller, D. J., Parikh, S. V., Pearson, N. L., Ravindran, A. V. & Uher, R., Sept 2016, In: Canadian Journal of Psychiatry. 61, 9, p. 540-560 21 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

841 Citations (Scopus)

Canadian Network for Mood and Anxiety Treatments (CANMAT) 2016 clinical guidelines for the management of adults with major depressive disorder: Section 2. Psychological treatments

Parikh, S. V., Quilty, L. C., Ravitz, P., Rosenbluth, M., Pavlova, B., Grigoriadis, S., Velyvis, V., Kennedy, S. H., Lam, R. W., MacQueen, G. M., Milev, R. V., Ravindran, A. V. & Uher, R., Sept 2016, In: Canadian Journal of Psychiatry. 61, 9, p. 524-539 16 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

261 Citations (Scopus)

Childhood maltreatment and comorbid anxiety in people with bipolar disorder

Pavlova, B., Perroud, N., Cordera, P., Uher, R., Dayer, A. & Aubry, J. M., Mar 1 2016, In: Journal of Affective Disorders. 192, p. 22-27 6 p.

Research output: Contribution to journal › Article › peer-review

31 Citations (Scopus)

Combining clinical variables to optimize prediction of antidepressant treatment outcomes

Iniesta, R., Malki, K., Maier, W., Rietschel, M., Mors, O., Hauser, J., Henigsberg, N., Dernovsek, M. Z., Souery, D., Stahl, D., Dobson, R., Aitchison, K. J., Farmer, A., Lewis, C. M., McGuffin, P. & Uher, R., Jul 1 2016, In: Journal of Psychiatric Research. 78, p. 94-102 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

126 Citations (Scopus)

Long-term effects of depression treatment

Uher, R. & Pavlova, B., Feb 1 2016, In: The Lancet Psychiatry. 3, 2, p. 95-96 2 p.

Research output: Contribution to journal › Comment/debate › peer-review

Open Access

17 Citations (Scopus)

Person-centered measurement-based care for depression

Uher, R., Oct 1 2016, In: World Psychiatry. 15, 3, p. 238-239 2 p.

Research output: Contribution to journal › Comment/debate › peer-review

Open Access

8 Citations (Scopus)

Phenotypic association analyses with copy number variation in recurrent depressive disorder

Rucker, J. J. H., Tansey, K. E., Rivera, M., Pinto, D., Cohen-Woods, S., Uher, R., Aitchison, K. J., Craddock, N., Owen, M. J., Jones, L., Jones, I., Korszun, A., Barnes, M. R., Preisig, M., Mors, O., Maier, W., Rice, J., Rietschel, M., Holsboer, F., Farmer, A. E., & 4 othersCraig, I. W., Scherer, S. W., McGuffin, P. & Breen, G., Feb 15 2016, In: Biological Psychiatry. 79, 4, p. 329-336 8 p.

Medicine

Research output: Contribution to journal › Article › peer-review

Open Access

18 Citations (Scopus)

Polygenic interactions with environmental adversity in the aetiology of major depressive disorder

Mullins, N., Power, R. A., Fisher, H. L., Hanscombe, K. B., Euesden, J., Iniesta, R., Levinson, D. F., Weissman, M. M., Potash, J. B., Shi, J., Uher, R., Cohen-Woods, S., Rivera, M., Jones, L., Jones, I., Craddock, N., Owen, M. J., Korszun, A., Craig, I. W., Farmer, A. E., & 3 othersMcGuffin, P., Breen, G. & Lewis, C. M., Mar 1 2016, In: Psychological Medicine. 46, 4, p. 759-770 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

140 Citations (Scopus)

Specific anxiety disorders and subsequent risk for bipolar disorder: A nationwide study

Meier, S. M., Uher, R., Mors, O., Dalsgaard, S., Munk-Olsen, T., Laursen, T. M., Mattheisen, M., Nordentoft, M., Mortensen, P. B. & Pavlova, B., Jun 1 2016, In: World Psychiatry. 15, 2, p. 187-188 2 p.

Research output: Contribution to journal › Letter › peer-review

5 Citations (Scopus)

Stimulant medication and psychotic symptoms in offspring of parents with mental Illness

MacKenzie, L. E., Abidi, S., Fisher, H. L., Propper, L., Bagnell, A., Morash-Conway, J., Glover, J. M., Cumby, J., Hajek, T., Schultze-Lutter, F., Pajer, K., Alda, M. & Uher, R., Jan 2016, In: Pediatrics. 137, 1, e20152486.

Research output: Contribution to journal › Article › peer-review

25 Citations (Scopus)

Transcriptomics and the mechanisms of antidepressant efficacy

Hodgson, K., Tansey, K. E., Powell, T. R., Coppola, G., Uher, R., Zvezdana Dernovšek, M., Mors, O., Hauser, J., Souery, D., Maier, W., Henigsberg, N., Rietschel, M., Placentino, A., Aitchison, K. J., Craig, I. W., Farmer, A. E., Breen, G., McGuffin, P. & Dobson, R., Jan 1 2016, In: European Neuropsychopharmacology. 26, 1, p. 105-112 8 p.

Research output: Contribution to journal › Article › peer-review

20 Citations (Scopus)

2015

A genetic risk score combining 32 SNPs is associated with body mass index and improves obesity prediction in people with major depressive disorder

Hung, C. F., Breen, G., Czamara, D., Corre, T., Wolf, C., Kloiber, S., Bergmann, S., Craddock, N., Gill, M., Holsboer, F., Jones, L., Jones, I., Korszun, A., Kutalik, Z., Lucae, S., Maier, W., Mors, O., Owen, M. J., Rice, J., Rietschel, M., & 10 othersUher, R., Vollenweider, P., Waeber, G., Craig, I. W., Farmer, A. E., Lewis, C. M., Müller-Myhsok, B., Preisig, M., McGuffin, P. & Rivera, M., Apr 17 2015, In: BMC Medicine. 13, 1, 86.

Research output: Contribution to journal › Article › peer-review

Open Access

56 Citations (Scopus)

Association of a brain methylation site with clinical outcomes in depression does not replicate across populations

Uher, R., Ripke, S., Müller-Myhsok, B., Lewis, C. M. & Perlis, R. H., Apr 1 2015, In: American Journal of Psychiatry. 172, 4, p. 395-397 3 p.

Research output: Contribution to journal › Letter › peer-review

3 Citations (Scopus)

Biomarkers of treatment outcome in schizophrenia: Defining a benchmark for clinical significance

Levine, S. Z., Rabinowitz, J., Uher, R. & Kapur, S., Oct 2015, In: European Neuropsychopharmacology. 25, 10, p. 1578-1585 8 p.

Medicine

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Evidence-based guidelines for treating depressive disorders with antidepressants: A revision of the 2008 British Association for Psychopharmacology guidelines

Cleare, A., Pariante, C. M., Young, A. H., Anderson, I. M., Christmas, D., Cowen, P. J., Dickens, C., Ferrier, I. N., Geddes, J., Gilbody, S., Haddad, P. M., Katona, C., Lewis, G., Malizia, A., McAllister-Williams, R. H., Ramchandani, P., Scott, J., Taylor, D. & Uher, R., May 5 2015, In: Journal of Psychopharmacology. 29, 5, p. 459-525 67 p.

Research output: Contribution to journal › Review article › peer-review

563 Citations (Scopus)

Exploring the role of drug-metabolising enzymes in antidepressant side effects

Hodgson, K., Tansey, K. E., Uher, R., Dernovšek, M. Z., Mors, O., Hauser, J., Souery, D., Maier, W., Henigsberg, N., Rietschel, M., Placentino, A., Craig, I. W., Aitchison, K. J., Farmer, A. E., Dobson, R. J. B. & McGuffin, P., Jul 26 2015, In: Psychopharmacology. 232, 14, p. 2609-2617 9 p., 3898.

Research output: Contribution to journal › Article › peer-review

Open Access

40 Citations (Scopus)

Rudolf Uher

Research output

Search results