4-Aminopyridine induces expansion of cutaneous receptive fields of dorsal horn cells

Kazue Semba; Herbert M. Geller; M. David Egger

doi:10.1016/0006-8993(85)90765-6

4-Aminopyridine induces expansion of cutaneous receptive fields of dorsal horn cells

Kazue Semba, Herbert M. Geller, M. David Egger

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

Systemic administration of 4-aminopyridine (4-AP) increased the size of the cutaneous receptive fields of 9 of the 15 dorsal horn cells tested. These receptive fields were on the feet and toes of the hind limbs of cats. Receptive field sizes increased with increasing doses of 4-AP. However, 4-AP administration did not change the responses of dorsal horn cells to graded mechanical stimuli administered near the centers of their receptive fields.

Original language	English
Pages (from-to)	398-402
Number of pages	5
Journal	Brain Research
Volume	343
Issue number	2
DOIs	https://doi.org/10.1016/0006-8993(85)90765-6
Publication status	Published - Sept 23 1985
Externally published	Yes

Bibliographical note

Funding Information:
This work was supported by grants from the UMDNJ Foundation (44-84), NIH (NS-19187 to H. M. G.) and NSF (BNS-8205598 to M. D. E.). We thank Suzan Harris and Pat Masarachia for technical assistance. Professor P. D. Wall suggested to us the use of 4-AP, and kindly shared preliminary results from similar work performed by himself and his colleagues, Drs. N. E. Saad6 and S. J. Jabbur.

ASJC Scopus Subject Areas

General Neuroscience
Molecular Biology
Clinical Neurology
Developmental Biology

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10.1016/0006-8993(85)90765-6

Cite this

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title = "4-Aminopyridine induces expansion of cutaneous receptive fields of dorsal horn cells",

abstract = "Systemic administration of 4-aminopyridine (4-AP) increased the size of the cutaneous receptive fields of 9 of the 15 dorsal horn cells tested. These receptive fields were on the feet and toes of the hind limbs of cats. Receptive field sizes increased with increasing doses of 4-AP. However, 4-AP administration did not change the responses of dorsal horn cells to graded mechanical stimuli administered near the centers of their receptive fields.",

author = "Kazue Semba and Geller, {Herbert M.} and Egger, {M. David}",

note = "Funding Information: This work was supported by grants from the UMDNJ Foundation (44-84), NIH (NS-19187 to H. M. G.) and NSF (BNS-8205598 to M. D. E.). We thank Suzan Harris and Pat Masarachia for technical assistance. Professor P. D. Wall suggested to us the use of 4-AP, and kindly shared preliminary results from similar work performed by himself and his colleagues, Drs. N. E. Saad6 and S. J. Jabbur.",

year = "1985",

month = sep,

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doi = "10.1016/0006-8993(85)90765-6",

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T1 - 4-Aminopyridine induces expansion of cutaneous receptive fields of dorsal horn cells

AU - Semba, Kazue

AU - Geller, Herbert M.

AU - Egger, M. David

N1 - Funding Information: This work was supported by grants from the UMDNJ Foundation (44-84), NIH (NS-19187 to H. M. G.) and NSF (BNS-8205598 to M. D. E.). We thank Suzan Harris and Pat Masarachia for technical assistance. Professor P. D. Wall suggested to us the use of 4-AP, and kindly shared preliminary results from similar work performed by himself and his colleagues, Drs. N. E. Saad6 and S. J. Jabbur.

PY - 1985/9/23

Y1 - 1985/9/23

N2 - Systemic administration of 4-aminopyridine (4-AP) increased the size of the cutaneous receptive fields of 9 of the 15 dorsal horn cells tested. These receptive fields were on the feet and toes of the hind limbs of cats. Receptive field sizes increased with increasing doses of 4-AP. However, 4-AP administration did not change the responses of dorsal horn cells to graded mechanical stimuli administered near the centers of their receptive fields.

AB - Systemic administration of 4-aminopyridine (4-AP) increased the size of the cutaneous receptive fields of 9 of the 15 dorsal horn cells tested. These receptive fields were on the feet and toes of the hind limbs of cats. Receptive field sizes increased with increasing doses of 4-AP. However, 4-AP administration did not change the responses of dorsal horn cells to graded mechanical stimuli administered near the centers of their receptive fields.

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4-Aminopyridine induces expansion of cutaneous receptive fields of dorsal horn cells

Abstract

Bibliographical note

ASJC Scopus Subject Areas

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