7α-HYDROXYLATION DU 27-HYDROXYCHOLESTEROL PAR DES MICROSOMES DE CERVEAU DE RAT

J. Zhang, Y. Akwa, E. E. Baulieu, J. Sjovall

Research output: Contribution to journalArticlepeer-review

29 Citations (Scopus)

Abstract

27-hydroxycholesterol is shown to be 7α-hydroxylated by microsomal preparations of rat brain. The apparent K(m) was about 2 μM and V(max) about 15 pmol/min x mg protein. The reaction might modulate biological functions of 27-hydroxycholesterol, such as its suppressive effect an the activity of 3-hydroxy-3-methylglutaryl-coenzyme A reductase, and supports the possibility of bile acid formation in the brain.

Original languageEnglish
Pages (from-to)345-349
Number of pages5
JournalComptes Rendus de l'Academie des Sciences - Serie III
Volume318
Issue number3
Publication statusPublished - 1995
Externally publishedYes

ASJC Scopus Subject Areas

  • General Agricultural and Biological Sciences
  • Developmental Biology

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