Abstract
27-hydroxycholesterol is shown to be 7α-hydroxylated by microsomal preparations of rat brain. The apparent K(m) was about 2 μM and V(max) about 15 pmol/min x mg protein. The reaction might modulate biological functions of 27-hydroxycholesterol, such as its suppressive effect an the activity of 3-hydroxy-3-methylglutaryl-coenzyme A reductase, and supports the possibility of bile acid formation in the brain.
| Original language | English |
|---|---|
| Pages (from-to) | 345-349 |
| Number of pages | 5 |
| Journal | Comptes Rendus de l'Academie des Sciences - Serie III |
| Volume | 318 |
| Issue number | 3 |
| Publication status | Published - 1995 |
| Externally published | Yes |
ASJC Scopus Subject Areas
- General Agricultural and Biological Sciences
- Developmental Biology