7α-HYDROXYLATION DU 27-HYDROXYCHOLESTEROL PAR DES MICROSOMES DE CERVEAU DE RAT

J. Zhang; Y. Akwa; E. E. Baulieu; J. Sjovall

7α-HYDROXYLATION DU 27-HYDROXYCHOLESTEROL PAR DES MICROSOMES DE CERVEAU DE RAT

J. Zhang, Y. Akwa, E. E. Baulieu, J. Sjovall

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Resumen

27-hydroxycholesterol is shown to be 7α-hydroxylated by microsomal preparations of rat brain. The apparent K(m) was about 2 μM and V(max) about 15 pmol/min x mg protein. The reaction might modulate biological functions of 27-hydroxycholesterol, such as its suppressive effect an the activity of 3-hydroxy-3-methylglutaryl-coenzyme A reductase, and supports the possibility of bile acid formation in the brain.

Idioma original	English
Páginas (desde-hasta)	345-349
Número de páginas	5
Publicación	Comptes Rendus de l'Academie des Sciences - Serie III
Volumen	318
N.º	3
Estado	Published - 1995
Publicado de forma externa	Sí

ASJC Scopus Subject Areas

General Agricultural and Biological Sciences
Developmental Biology

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abstract = "27-hydroxycholesterol is shown to be 7α-hydroxylated by microsomal preparations of rat brain. The apparent K(m) was about 2 μM and V(max) about 15 pmol/min x mg protein. The reaction might modulate biological functions of 27-hydroxycholesterol, such as its suppressive effect an the activity of 3-hydroxy-3-methylglutaryl-coenzyme A reductase, and supports the possibility of bile acid formation in the brain.",

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AU - Zhang, J.

AU - Akwa, Y.

AU - Baulieu, E. E.

AU - Sjovall, J.

PY - 1995

Y1 - 1995

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AB - 27-hydroxycholesterol is shown to be 7α-hydroxylated by microsomal preparations of rat brain. The apparent K(m) was about 2 μM and V(max) about 15 pmol/min x mg protein. The reaction might modulate biological functions of 27-hydroxycholesterol, such as its suppressive effect an the activity of 3-hydroxy-3-methylglutaryl-coenzyme A reductase, and supports the possibility of bile acid formation in the brain.

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7α-HYDROXYLATION DU 27-HYDROXYCHOLESTEROL PAR DES MICROSOMES DE CERVEAU DE RAT

Resumen

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