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• Adopting patient-centred tools in cancer care: Role of evidence and other factors

  Glenn, A. & Urquhart, R., Feb 2019, In: Current Oncology. 26, 1, p. 19-27 9 p.

  Medicine

  Research output: Contribution to journal › Article › peer-review

  Open Access
  4 Citations (Scopus)

• Adopting the New Anticoagulants: All Aboard or All in Good Time?

  Deyell, M. W., Cox, J. L., Bennett, M. T., Wong, G. C., Teal, P. A. & Krahn, A. D., Oct 2013, In: Canadian Journal of Cardiology. 29, 10, p. 1295-1298 4 p.

  Research output: Contribution to journal › Article › peer-review
  3 Citations (Scopus)

• Adoption of azygos, hemiazygos, and dartos

  Neumann, P. E., May 2017, In: Clinical Anatomy. 30, 4, p. 450-451 2 p.

  Research output: Contribution to journal › Article › peer-review
  4 Citations (Scopus)

• Adoption of open-access scheduling in an academic family practice

  Cameron, S., Sadler, L. & Lawson, B., Sept 2010, In: Canadian Family Physician. 56, 9, p. 906-911 6 p.

  Research output: Contribution to journal › Article › peer-review
  36 Citations (Scopus)

• Adoptive transfer of immunity to Trichinella spiralis in mice: Generation of effective cells by different life cycle stages

  Grencis, R. K., Lee, T. D. G. & Wakelin, D., Apr 1985, In: International Journal for Parasitology. 15, 2, p. 195-202 8 p.

  Research output: Contribution to journal › Article › peer-review
  4 Citations (Scopus)

• A dose-response relationship between exposure to a large-scale HIV preventive intervention and consistent condom use with different sexual partners of female sex workers in southern India

  Deering, K. N., Boily, M. C., Lowndes, C. M., Shoveller, J., Tyndall, M. W., Vickerman, P., Bradley, J., Gurav, K., Pickles, M., Moses, S., Ramesh, B. M., Washington, R., Rajaram, S. & Alary, M., 2011, In: BMC Public Health. 11, SUPPL. 6, S8.

  Research output: Contribution to journal › Review article › peer-review

  Open Access
  36 Citations (Scopus)

• A dose-response study of the effects of alcohol on the perceptions of pain and discomfort due to electric shock in men at high familial-genetic risk for alcoholism

  Stewart, S. H., Finn, P. R. & Pihl, R. O., Jun 1995, In: Psychopharmacology. 119, 3, p. 261-267 7 p.

  Medicine

  Research output: Contribution to journal › Review article › peer-review
  55 Citations (Scopus)

• A double-blind, placebo-controlled, crossover pilot trial with extension using an oral mucosal cannabinoid extract for treatment of chemotherapy-induced neuropathic pain

  Lynch, M. E., Cesar-Rittenberg, P. & Hohmann, A. G., Jan 2014, In: Journal of Pain and Symptom Management. 47, 1, p. 166-173 8 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  205 Citations (Scopus)

• A double-blind, randomized phase II trial of the safety and immunogenicity of 26-valent group A streptococcus vaccine in healthy adults

  McNeil, S. A., Halperin, S. A., Langley, J. M., Smith, B., Baxendale, D. M., Warren, A., Sharratt, G. P., Reddish, M. A., Fries, L. F., Vink, P. E. & Dale, J. B., Apr 2006, In: International Congress Series. 1289, p. 303-306 4 p.

  Medicine

  Research output: Contribution to journal › Article › peer-review
  22 Citations (Scopus)

• A double-masked comparison of betaxolol and dipivefrin for the treatment of increased intraocular pressure

  Albracht, D. C., LeBlanc, R. P., Cruz, A. M., Lamping, K. A., Siegel, L. I., Stern, K. L., Kelley, E. P. & Stoecker, J. F., 1993, In: American Journal of Ophthalmology. 116, 3, p. 307-313 7 p.

  Research output: Contribution to journal › Article › peer-review
  7 Citations (Scopus)

• Adrenalectomy in mice does not prevent loss of intestinal lymphocytes after exercise

  Hoffman-Goetz, L., Quadrilatero, J., Boudreau, J. & Guan, J., Jun 2004, In: Journal of Applied Physiology. 96, 6, p. 2073-2081 9 p.

  Research output: Contribution to journal › Article › peer-review
  10 Citations (Scopus)

• Adrenal Function Tests in Mice Sensitized to Histamine with Hemophilus pertussis Vaccine

  Kind, L. S. & Gadsden, R. H., Nov 1953, In: Experimental Biology and Medicine. 84, 2, p. 373-375 3 p.

  Research output: Contribution to journal › Article › peer-review
  4 Citations (Scopus)

• Adrenergic and possible nonadrenergic sources of adenosine 5'-triphosphate release from nerve varicosities isolated from ileal myenteric plexus

  Al-Humayyd, M. & White, T. D., 1985, In: Journal of Pharmacology and Experimental Therapeutics. 233, 3, p. 796-800 5 p.

  Medicine

  Research output: Contribution to journal › Article › peer-review
  16 Citations (Scopus)

• Adrenergic control of swimbladder deflation in the zebrafish (Danio rerio)

  Dumbarton, T. C., Stoyek, M., Croll, R. P. & Smith, F. M., Jul 15 2010, In: Journal of Experimental Biology. 213, 14, p. 2536-2546 11 p.

  Medicine

  Research output: Contribution to journal › Article › peer-review
  23 Citations (Scopus)

• Adrenergic drugs and their antagonists.

  NICKERSON, M. & DRESEL, P. E., Sept 1958, In: Postgraduate Medicine. 24, 3, p. 246-256 11 p.

  Medicine

  Research output: Contribution to journal › Article › peer-review
  1 Citation (Scopus)

• Adrenergic regulation of AMP-activated protein kinase in brown adipose tissue in vivo

  Pulinilkunnil, T., He, H., Kong, D., Asakura, K., Peroni, O. D., Lee, A. & Kahn, B. B., Mar 18 2011, In: Journal of Biological Chemistry. 286, 11, p. 8798-8809 12 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  74 Citations (Scopus)

• Adrenergic regulation of calcium-activated potassium current in cultured rabbit pigmented ciliary epithelial cells

  Ryan, J. S., Tao, Q. P. & Kelly, M. E. M., Aug 15 1998, In: Journal of Physiology. 511, 1, p. 145-157 13 p.

  Medicine

  Research output: Contribution to journal › Article › peer-review
  9 Citations (Scopus)

• Adrenergic regulation of P2X3 and TRPV1 receptors: Differential effects of spared nerve injury

  Meisner, J. G., Reid, A. R. & Sawynok, J., Oct 24 2008, In: Neuroscience Letters. 444, 2, p. 172-175 4 p.

  Medicine

  Research output: Contribution to journal › Article › peer-review
  9 Citations (Scopus)

• Adrenoleukodystrophy associated with psychosis [2]

  Kopala, L. C., Tan, S., Shea, C., Orlik, H., Vandorpe, R. & Honer, W. G., Oct 27 2000, In: Schizophrenia Research. 45, 3, p. 263-265 3 p.

  Research output: Contribution to journal › Letter › peer-review
  8 Citations (Scopus)

• Adrenoleukodystrophy Mimicking Multiple Sclerosis

  Dooley, J. M. & Wright, B. A., Feb 1985, In: Canadian Journal of Neurological Sciences. 12, 1, p. 73-74 2 p.

  Medicine

  Research output: Contribution to journal › Article › peer-review

  Open Access
  33 Citations (Scopus)

• A Dual Frequency Lens Focused Endoscopic Histotripsy Transducer

  Mallay, M. G., Woodacre, J. K., Landry, T. G., Campbell, N. A. & Brown, J. A., 2021, (Accepted/In press) In: IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control.

  Research output: Contribution to journal › Article › peer-review
  12 Citations (Scopus)

• Adult-acquired laryngeal stenosis: A study of prognostic factors

  Massoud, E. A. S. & McCullough, D. W., 1995, In: Journal of Otolaryngology. 24, 4, p. 234-237 4 p.

  Research output: Contribution to journal › Article › peer-review
  6 Citations (Scopus)

• Adult attention-deficit hyperactivity disorder symptoms and psychological distress, hazardous drinking, and problem gambling: A population-based study

  McDonald, A. J., Cook, S., Turner, N. E., Ialomiteanu, A. R., Mann, R. E., Bondy, S. J., Roerecke, M., McCready, J., Millstone, D., Hamilton, H. A., Elton-Marshall, T., Rehm, J., Kurdyak, P., Ilie, G., Vingilis, E. R., Wickens, C. M., van der Maas, M. & Cusimano, M. D., Jul 2021, In: Psychiatry Research. 301, 113985.

  Research output: Contribution to journal › Article › peer-review
  4 Citations (Scopus)

• Adult cardiomyocytes express functional high-affinity receptors for basic fibroblast growth factor

  Liu, L., Pasumarthi, K. B. S., Padua, R. R., Massaeli, H., Fandrich, R. R., Pierce, G. N., Cattini, P. A. & Kardami, E., 1995, In: American Journal of Physiology - Heart and Circulatory Physiology. 268, 5 37-5, p. H1927-H1938

  Research output: Contribution to journal › Article › peer-review
  56 Citations (Scopus)

• Adult granulosa cell tumor of the testicle

  Norman, R. W., Sheridan-Jonah, A., Merrimen, J. & Gupta, R., 2013, In: Canadian Journal of Urology. 20, 1, p. 6640-6642 3 p.

  Medicine

  Research output: Contribution to journal › Article › peer-review
  3 Citations (Scopus)

• Adult headbanging: Sleep studies and treatment

  Chisholm, T. & Morehouse, R. L., 1996, In: Sleep. 19, 4, p. 343-346 4 p.

  Medicine

  Research output: Contribution to journal › Article › peer-review

  Open Access
  67 Citations (Scopus)

• Adult height and the risk of cause-specific death and vascular morbidity in 1 million people: Individual participant meta-analysis

  Wormser, D., Di Angelantonio, E., Kaptoge, S., Wood, A. M., Gao, P., Sun, Q., Walldius, G., Selmer, R., Monique Verschuren, W. M., Bueno-de-Mesquita, H. B., Engström, G., Ridker, P. M., Njølstad, I., Iso, H., Holme, I., Giampaoli, S., Tunstall-Pedoe, H., Gaziano, J. M., Brunner, E., Kee, F., & 246 othersTosetto, A., Meisinger, C., Brenner, H., Ducimetiere, P., Whincup, P. H., Tipping, R. W., Ford, I., Cremer, P., Hofman, A., Wilhelmsen, L., Clarke, R., de Boer, I. H., Jukema, J. W., Ibañez, A. M., Lawlor, D. A., D'Agostino, R. B., Rodriguez, B., Casiglia, E., Stehouwer, C. D. A., Simons, L. A., Nietert, P. J., Barrett-Connor, E., Panagiotakos, D. B., Björkelund, C., Strandberg, T. E., Wassertheil-Smoller, S., Blazer, D. G., Meade, T. W., Welin, L., Svärdsudd, K., Woodward, M., Nissinen, A., Kromhout, D., Jørgensen, T., Tilvis, R. S., Guralnik, J. M., Rosengren, A., Taylor, J. O., Kiechl, S., Dagenais, G. R., Fowkes, F. G. R., Wallace, R. B., Khaw, K. T., Shaffer, J. A., Visser, M., Kauhanen, J., Salonen, J. T., Gallacher, J., Ben-Shlomo, Y., Kitamura, A., Sundström, J., Wennberg, P., Kiyohara, Y., Daimon, M., de la Cámara, A. G., Cooper, J. A., Onat, A., Devereux, R., Mukamal, K. J., Dankner, R., Knuiman, M. W., Crespo, C. J., Gansevoort, R. T., Goldbourt, U., Nordestgaard, B. G., Shaw, J. E., Mussolino, M., Nakagawa, H., Fletcher, A., Kuller, L. H., Gillum, R. F., Gudnason, V., Assmann, G., Wald, N., Jousilahti, P. R., Greenland, P., Trevisan, M., Ulmer, H., Butterworth, A. S., Folsom, A. R., Davey-Smith, G., Hu, F. B., Danesh, J., Simpson, L. M., Jungner, I., Demerath, E. W., Franceschini, N., Lutsey, P. L., Pitsavos, C., Chrysohoou, C., Stefanadis, C., Atkins, R., Zimmet, P. Z., Barr, E. L. M., Wannamethee, S. G., Morris, R. W., Willeit, J., Weger, S., Oberhollenzer, F., Ebrahim, S., Yarnell, J. W. G., Tikhonoff, V., Shay, C. M., Garside, D. B., Sutherland, S. E., Bachman, D. L., Keil, J. E., Kizer, J. R., Psaty, B. M., Tybjærg-Hansen, A., Jensen, G. B., Schnohr, P., Palmieri, L., Panico, S., Pilotto, L., Vanuzzo, D., Simons, J., McCallum, J., Friedlander, Y., Phillips, C. L., Kohout, F. J., Cornoni-Huntley, J. C., Wareham, N. J., Schöttker, B., Müller, H., Rothenbacher, D., Jansson, J. H., Donfrancesco, C., Vartiainen, E., Harald, K., Salomaa, V., Vasan, R. S., Fox, C. S., Pencina, M. J., Oizumi, T., Kayama, T., Kato, T., Bladbjerg, E. M., Møller, L., Jespersen, J., Chetrit, A., Lubin, F., Eriksson, H., Lappas, G., Bengtsson, C., Lissner, L., Nagel, D., Miettinen, T. A., Arima, H., Doi, Y., Ninomiya, T., Dekker, J. M., Nijpels, G., Rimm, E. B., Willett, W. C., Yamagishi, K., Noda, H., Kurl, S., Tuomainen, T. P., Poppelaars, J. L., Deeg, D. J. H., De Stavola, B. L., Hedblad, B., Nilsson, P., Blokstra, A., Shea, S. J., Thorand, B., Koenig, W., Döring, A., Nitsch, D., Grandits, G., Tverdal, A., Nystad, W., Manson, J. E., Hankinson, S. E., Bauer, K. A., Davidson, K. W., Kirkland, S., Shimbo, D., Sato, S., Miura, K., Sakurai, M., Jouven, X., Bakker, S. J. L., van der Harst, P., Hillege, H. L., Garcia-Palmieri, M. R., Amouyel, P., Arveiler, D., Ferrières, J., Schulte, H., de Craen, A. J. M., Sattar, N., Stott, D. J., Cantin, B., Lamarche, B., Després, J. P., Bergstrom, J., Bettencourt, R. R., Buisson, C., Aspelund, T., Sigurdsson, G., Thorsson, B., Ikram, M. A., Tiemeier, H., Witteman, J. C. M., Tavendale, R., Lowe, G. D. O., Yeh, J. L., Ali, T., Calhoun, D., Can, G., Nakamura, K., Morikawa, Y., Mathiesen, E. B., Løchen, M. L., Wilsgaard, T., Ingelsson, E., Michaëlsson, K., Cederholm, T., Buring, J., Diem, G., Concin, H., Rodeghiero, F., Marmot, M., Kivimaki, M. S. M., Robertson, M., Feskens, E., Geleijnse, J. M., Kromhout, D., Walker, M., Watson, S., Alexander, M., Franco, O. H., Gobin, R., Haycock, P., Kaptoge, S., Seshasai, S. R. K., Lewington, S., Pennells, L., Rapsomaniki, E., Sarwar, N., Thompson, A., Thompson, S. G., White, I. R. & Zhao, X., Oct 1 2012, In: International Journal of Epidemiology. 41, 5, p. 1419-1433 15 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  220 Citations (Scopus)

• Adult neurogenesis and cellular brain repair with neural progenitors, precursors and stem cells

  Shivraj Sohur, U., Emsley, J. G., Mitchell, B. D. & Macklis, J. D., Sept 29 2006, In: Philosophical Transactions of the Royal Society B: Biological Sciences. 361, 1473, p. 1477-1497 21 p.

  Research output: Contribution to journal › Review article › peer-review
  138 Citations (Scopus)

• Adult neurogenesis and repair of the adult CNS with neural progenitors, precursors, and stem cells

  Emsley, J. G., Mitchell, B. D., Kempermann, G. & Macklis, J. D., Apr 2005, In: Progress in Neurobiology. 75, 5, p. 321-341 21 p.

  Research output: Contribution to journal › Review article › peer-review
  358 Citations (Scopus)

• Adult scoliosis

  Donaldson, W. F. & Oxner, W. M., 2000, In: Seminars in Spine Surgery. 12, 3, p. 104-109 6 p.

  Research output: Contribution to journal › Review article › peer-review

• Adult transgender care: A review for urologists

  Anderson, K., Krakowsky, Y., Potter, E., Hudson, J. & Cox, A. R., Oct 2021, In: Journal of the Canadian Urological Association. 15, 10

  Research output: Contribution to journal › Review article › peer-review

  Open Access
  10 Citations (Scopus)

• Advance Care Planning: Understanding Clinical Routines and Experiences of Interprofessional Team Members in Diverse Health Care Settings

  Arnett, K., Sudore, R. L., Nowels, D., Feng, C. X., Levy, C. R. & Lum, H. D., Dec 1 2017, In: American Journal of Hospice and Palliative Medicine. 34, 10, p. 946-953 8 p.

  Research output: Contribution to journal › Article › peer-review
  51 Citations (Scopus)

• Advance care planning and decision-making in a home-based primary care service in a Canadian urban centre

  Huggins, M., McGregor, M. J., Cox, M. B., Bauder, K., Slater, J., Yap, C., Mallery, L., Moorhouse, P. & Rusnak, C., 2019, In: Canadian Geriatrics Journal. 22, 4, p. 182-189 8 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  9 Citations (Scopus)

• Advanced biological age is associated with improved antibody responses in older high-dose influenza vaccine recipients over four consecutive seasons

  Verschoor, C. P., Belsky, D. W., Andrew, M. K., Haynes, L., Loeb, M., Pawelec, G., McElhaney, J. E. & Kuchel, G. A., Dec 2022, In: Immunity and Ageing. 19, 1, 39.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  9 Citations (Scopus)

• Advanced chronic obstructive pulmonary disease: Innovative approaches to palliation

  Rocker, G. M., Sinuff, T., Horton, R. & Hernandez, P., Jun 2007, In: Journal of Palliative Medicine. 10, 3, p. 783-797 15 p.

  Research output: Contribution to journal › Review article › peer-review

  Open Access
  66 Citations (Scopus)

• Advanced glycation end-product cross-linking inhibits biomechanical plasticity and characteristic failure morphology of native tendon

  Lee, J. M. & Veres, S. P., Jan 17 2019, In: Journal of Applied Physiology. 126, 4, p. 832-841 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  36 Citations (Scopus)

• Advanced paternal age and sperm DNA fragmentation: A systematic review

  Gonzalez, D. C., Ory, J., Blachman-Braun, R., Nackeeran, S., Best, J. C. & Ramasamy, R., 2021, In: World Journal of Men?s Health. 39, p. 1-12 12 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  17 Citations (Scopus)

• Advanced vaccinology education: Landscaping its growth and global footprint

  the Global Vaccinology Training Collaborative, Jun 19 2020, In: Vaccine. 38, 30, p. 4664-4670 7 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  8 Citations (Scopus)

• Advanced vaccinology training globally: Update and impact of the COVID-19 crisis

  the Global Vaccinology Training Collaborative, Sept 16 2022, In: Vaccine. 40, 39, p. 5683-5690 8 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  3 Citations (Scopus)

• Advanced vertebral fracture among newly diagnosed children with acute lymphoblastic leukemia: Results of the Canadian Steroid-Associated Osteoporosis in the Pediatric Population (STOPP) research program

  Halton, J., Gaboury, I., Grant, R., Alos, N., Cummings, E. A., Matzinger, M., Shenouda, N., Lentle, B., Abish, S., Atkinson, S., Cairney, E., Dix, D., Israels, S., Stephure, D., Wilson, B., Hay, J., Moher, D., Rauch, F., Siminoski, K., Ward, L. M., & 41 othersFeber, J., Roth, J., Kloiber, R., Lewis, V., Midgley, J., Miettunen, P., Cabral, D., Nadel, H. R., White, C., Clarson, C., Filler, G., Grimmer, J., Sparrow, K., Fernandez, C., Huber, A. M., Lang, B., O'Brien, K., Ross, A., Arora, S., Barr, R., Coblentz, C., Dent, P. B., Webber, C., Rodd, C., Bell, L., Scuccimarri, R., Glorieux, F., Dubois, J., Laverdière, C., Phan, V., Saint-Cyr, C., Couch, R., Ellsworth, J., LeBlanc, C., Pinsk, M., Charron, M., Hebert, D., Taback, S., Blydt-Hansen, T., Oen, K. & Reed, M., Jul 2009, In: Journal of Bone and Mineral Research. 24, 7, p. 1326-1334 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  186 Citations (Scopus)

• Advances in airway management

  Hung, O. & Law, J. A., Jun 2006, In: Canadian Journal of Anaesthesia. 53, 6, p. 628-631 4 p.

  Medicine

  Research output: Contribution to journal › Review article › peer-review

  Open Access
  16 Citations (Scopus)

• Advances in clinical islet isolation

  Pepper, A. R., Gala-Lopez, B. & Kin, T., Jan 1 2015, Islets of Langerhans, Second Edition. Springer Netherlands, p. 1165-1197 33 p.

  Research output: Chapter in Book/Report/Conference proceeding › Chapter
  2 Citations (Scopus)

• Advances in degradable embolic microspheres: A state of the art review

  Doucet, J., Kiri, L., O'Connell, K., Kehoe, S., Lewandowski, R. J., Liu, D. M., Abraham, R. J. & Boyd, D., Jan 26 2018, In: Journal of Functional Biomaterials. 9, 1, 14.

  Research output: Contribution to journal › Review article › peer-review

  Open Access
  48 Citations (Scopus)

• Advances in diagnosis, treatment and palliation of cholangiocarcinoma: 1990-2009

  Aljiffry, M., Walsh, M. J. & Molinari, M., 2009, In: World Journal of Gastroenterology. 15, 34, p. 4240-4262 23 p.

  Research output: Contribution to journal › Review article › peer-review

  Open Access
  234 Citations (Scopus)

• Advances in diagnosis, treatment and palliation of pancreatic carcinoma: 1990-2010

  Sharma, C., Eltawil, K. M., Renfrew, P. D., Walsh, M. J. & Molinari, M., Feb 21 2011, In: World Journal of Gastroenterology. 17, 7, p. 867-897 31 p.

  Medicine

  Research output: Contribution to journal › Article › peer-review

  Open Access
  180 Citations (Scopus)

• Advances in high-field magnetic resonance spectroscopy in Alzheimer's disease

  Zhang, N., Song, X., Bartha, R., Beyea, S., D'Arcy, R., Zhang, Y. & Rockwood, K., 2014, In: Current Alzheimer Research. 11, 4, p. 367-388 22 p.

  Research output: Contribution to journal › Review article › peer-review
  26 Citations (Scopus)

• Advances in myocardial contrast echocardiography and the role of adenosine stress

  Mulvagh, S. L., Jul 22 2004, In: American Journal of Cardiology. 94, 2 SUPPL. 1, p. 12-17 6 p.

  Research output: Contribution to journal › Article › peer-review
  10 Citations (Scopus)

• Advances in perfusion magnetic resonance imaging in Alzheimer's disease

  Chen, W., Song, X., Beyea, S., D'Arcy, R., Zhang, Y. & Rockwood, K., Mar 2011, In: Alzheimer's and Dementia. 7, 2, p. 185-196 12 p.

  Medicine

  Research output: Contribution to journal › Review article › peer-review
  48 Citations (Scopus)

• Advances in prehospital immediate care

  Stewart, R. D., 1989, In: Resuscitation. 18, SUPPL., p. S13-S20

  Research output: Contribution to journal › Article › peer-review
  10 Citations (Scopus)

• Advances in squid biology, ecology and fisheries. Part II - oegopsid squids

  Rosa, R., Pierce, G. & O'dor, R., 2013, Nova Science Publishers, Inc. 281 p.

  Research output: Book/Report › Book
  15 Citations (Scopus)