Abstract
The prevalence of naturally occurring anti-IgE autoantibodies was assessed by surveying 387 sera from atopic, nonatopic, and autoimmune patients. A significant number of children (28.5%) and adults (20%) with no history of allergy had high levels of auto-anti-IgE. The level of autoantibodies to IgE in children with clinical asthma or atopic eczema was not significantly elevated over normal. Similarly, adults with atopic asthma, allergic rhinitis, or urticaria or sera from individuals with rheumatoid arthritis or systemic lupus erythromatosis showed no significant elevation of auto-anti-IgE. In contrast, 82% of adults with eczema had medium to high levels of auto-anti-IgE and the mean concentration in sera was significantly (P < 0.01) raised. The relevance of auto-anti-IgE in atopic eczema is discussed.
| Original language | English |
|---|---|
| Pages (from-to) | 40-51 |
| Number of pages | 12 |
| Journal | Clinical Immunology and Immunopathology |
| Volume | 53 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Oct 1989 |
| Externally published | Yes |
Bibliographical note
Funding Information:We thank Sian Pinkerton and Sarah Matthews for technical help, Dr. Dennis Stanworth, Birmingham, for the human IgE myeloma. and the staff of Medeval Ltd.. Manchester University, especially Dr. K. Hopkins for providing normal serum samples. The study was supported by an MRC project grant and a grant from the North West Regional Health Authority.
ASJC Scopus Subject Areas
- Immunology and Allergy
- Pathology and Forensic Medicine
- Immunology
PubMed: MeSH publication types
- Comparative Study
- Journal Article
- Research Support, Non-U.S. Gov't