A survey of nonatopic and atopic children and adults for the presence of anti-IgE autoantibodies

D. M. Twena; J. S. Marshall; M. R. Haeney; E. B. Bell

doi:10.1016/0090-1229(89)90099-8

A survey of nonatopic and atopic children and adults for the presence of anti-IgE autoantibodies

D. M. Twena, J. S. Marshall, M. R. Haeney, E. B. Bell

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16 Citas (Scopus)

Resumen

The prevalence of naturally occurring anti-IgE autoantibodies was assessed by surveying 387 sera from atopic, nonatopic, and autoimmune patients. A significant number of children (28.5%) and adults (20%) with no history of allergy had high levels of auto-anti-IgE. The level of autoantibodies to IgE in children with clinical asthma or atopic eczema was not significantly elevated over normal. Similarly, adults with atopic asthma, allergic rhinitis, or urticaria or sera from individuals with rheumatoid arthritis or systemic lupus erythromatosis showed no significant elevation of auto-anti-IgE. In contrast, 82% of adults with eczema had medium to high levels of auto-anti-IgE and the mean concentration in sera was significantly (P < 0.01) raised. The relevance of auto-anti-IgE in atopic eczema is discussed.

Idioma original	English
Páginas (desde-hasta)	40-51
Número de páginas	12
Publicación	Clinical Immunology and Immunopathology
Volumen	53
N.º	1
DOI	https://doi.org/10.1016/0090-1229(89)90099-8
Estado	Published - oct. 1989
Publicado de forma externa	Sí

Nota bibliográfica

Funding Information:
We thank Sian Pinkerton and Sarah Matthews for technical help, Dr. Dennis Stanworth, Birmingham, for the human IgE myeloma. and the staff of Medeval Ltd.. Manchester University, especially Dr. K. Hopkins for providing normal serum samples. The study was supported by an MRC project grant and a grant from the North West Regional Health Authority.

ASJC Scopus Subject Areas

Immunology and Allergy
Pathology and Forensic Medicine
Immunology

PubMed: MeSH publication types

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

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abstract = "The prevalence of naturally occurring anti-IgE autoantibodies was assessed by surveying 387 sera from atopic, nonatopic, and autoimmune patients. A significant number of children (28.5%) and adults (20%) with no history of allergy had high levels of auto-anti-IgE. The level of autoantibodies to IgE in children with clinical asthma or atopic eczema was not significantly elevated over normal. Similarly, adults with atopic asthma, allergic rhinitis, or urticaria or sera from individuals with rheumatoid arthritis or systemic lupus erythromatosis showed no significant elevation of auto-anti-IgE. In contrast, 82% of adults with eczema had medium to high levels of auto-anti-IgE and the mean concentration in sera was significantly (P < 0.01) raised. The relevance of auto-anti-IgE in atopic eczema is discussed.",

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AU - Bell, E. B.

N1 - Funding Information: We thank Sian Pinkerton and Sarah Matthews for technical help, Dr. Dennis Stanworth, Birmingham, for the human IgE myeloma. and the staff of Medeval Ltd.. Manchester University, especially Dr. K. Hopkins for providing normal serum samples. The study was supported by an MRC project grant and a grant from the North West Regional Health Authority.

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N2 - The prevalence of naturally occurring anti-IgE autoantibodies was assessed by surveying 387 sera from atopic, nonatopic, and autoimmune patients. A significant number of children (28.5%) and adults (20%) with no history of allergy had high levels of auto-anti-IgE. The level of autoantibodies to IgE in children with clinical asthma or atopic eczema was not significantly elevated over normal. Similarly, adults with atopic asthma, allergic rhinitis, or urticaria or sera from individuals with rheumatoid arthritis or systemic lupus erythromatosis showed no significant elevation of auto-anti-IgE. In contrast, 82% of adults with eczema had medium to high levels of auto-anti-IgE and the mean concentration in sera was significantly (P < 0.01) raised. The relevance of auto-anti-IgE in atopic eczema is discussed.

AB - The prevalence of naturally occurring anti-IgE autoantibodies was assessed by surveying 387 sera from atopic, nonatopic, and autoimmune patients. A significant number of children (28.5%) and adults (20%) with no history of allergy had high levels of auto-anti-IgE. The level of autoantibodies to IgE in children with clinical asthma or atopic eczema was not significantly elevated over normal. Similarly, adults with atopic asthma, allergic rhinitis, or urticaria or sera from individuals with rheumatoid arthritis or systemic lupus erythromatosis showed no significant elevation of auto-anti-IgE. In contrast, 82% of adults with eczema had medium to high levels of auto-anti-IgE and the mean concentration in sera was significantly (P < 0.01) raised. The relevance of auto-anti-IgE in atopic eczema is discussed.

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A survey of nonatopic and atopic children and adults for the presence of anti-IgE autoantibodies

Resumen

Nota bibliográfica

ASJC Scopus Subject Areas

PubMed: MeSH publication types

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Huella

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