Adenosine modulates Toll-like receptor function: Basic mechanisms and translational opportunities

Melanie R. Power Coombs; Mirjam E. Belderbos; Leighanne C. Gallington; Louis Bont; Ofer Levy

doi:10.1586/eri.10.158

Adenosine modulates Toll-like receptor function: Basic mechanisms and translational opportunities

Melanie R. Power Coombs, Mirjam E. Belderbos, Leighanne C. Gallington, Louis Bont, Ofer Levy

Research output: Contribution to journal › Review article › peer-review

31 Citations (Scopus)

Abstract

Adenosine is an endogenous purine metabolite whose concentration in human blood plasma rises from nanomolar to micromolar concentrations during the inflammatory process. Leukocytes express seven-transmembrane adenosine receptors whose engagement modulates Toll-like receptor-mediated cytokine responses, in part via modulation of intracellular cyclic adenosine monophosphate. Adenosine analogs are used clinically to treat arrhythmias and apnea of prematurity. Herein, we consider the potential of adenosine analogs as innate immune response modifiers to prevent and/or treat infection.

Original language	English
Pages (from-to)	261-269
Number of pages	9
Journal	Expert Review of Anti-Infective Therapy
Volume	9
Issue number	2
DOIs	https://doi.org/10.1586/eri.10.158
Publication status	Published - Feb 2011
Externally published	Yes

ASJC Scopus Subject Areas

Microbiology
Microbiology (medical)
Virology
Infectious Diseases

PubMed: MeSH publication types

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1586/eri.10.158

Cite this

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abstract = "Adenosine is an endogenous purine metabolite whose concentration in human blood plasma rises from nanomolar to micromolar concentrations during the inflammatory process. Leukocytes express seven-transmembrane adenosine receptors whose engagement modulates Toll-like receptor-mediated cytokine responses, in part via modulation of intracellular cyclic adenosine monophosphate. Adenosine analogs are used clinically to treat arrhythmias and apnea of prematurity. Herein, we consider the potential of adenosine analogs as innate immune response modifiers to prevent and/or treat infection.",

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AU - Gallington, Leighanne C.

AU - Bont, Louis

AU - Levy, Ofer

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AB - Adenosine is an endogenous purine metabolite whose concentration in human blood plasma rises from nanomolar to micromolar concentrations during the inflammatory process. Leukocytes express seven-transmembrane adenosine receptors whose engagement modulates Toll-like receptor-mediated cytokine responses, in part via modulation of intracellular cyclic adenosine monophosphate. Adenosine analogs are used clinically to treat arrhythmias and apnea of prematurity. Herein, we consider the potential of adenosine analogs as innate immune response modifiers to prevent and/or treat infection.

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Adenosine modulates Toll-like receptor function: Basic mechanisms and translational opportunities

Abstract

ASJC Scopus Subject Areas

PubMed: MeSH publication types

UN SDGs

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