Adenosine modulates Toll-like receptor function: Basic mechanisms and translational opportunities

Melanie R. Power Coombs, Mirjam E. Belderbos, Leighanne C. Gallington, Louis Bont, Ofer Levy

Résultat de recherche: Review articleexamen par les pairs

31 Citations (Scopus)

Résumé

Adenosine is an endogenous purine metabolite whose concentration in human blood plasma rises from nanomolar to micromolar concentrations during the inflammatory process. Leukocytes express seven-transmembrane adenosine receptors whose engagement modulates Toll-like receptor-mediated cytokine responses, in part via modulation of intracellular cyclic adenosine monophosphate. Adenosine analogs are used clinically to treat arrhythmias and apnea of prematurity. Herein, we consider the potential of adenosine analogs as innate immune response modifiers to prevent and/or treat infection.

Langue d'origineEnglish
Pages (de-à)261-269
Nombre de pages9
JournalExpert Review of Anti-Infective Therapy
Volume9
Numéro de publication2
DOI
Statut de publicationPublished - févr. 2011
Publié à l'externeOui

ASJC Scopus Subject Areas

  • Microbiology
  • Microbiology (medical)
  • Virology
  • Infectious Diseases

PubMed: MeSH publication types

  • Journal Article
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

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