Altered mitogen- and alloantigen-induced lymphoproliferative responses in primary lymphoid organs of pregnant mice

D. W. Hoskin; R. A. Murgita

doi:10.1016/0165-0378(85)90031-2

Altered mitogen- and alloantigen-induced lymphoproliferative responses in primary lymphoid organs of pregnant mice

D. W. Hoskin, R. A. Murgita

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

The effect of syngeneic murine pregnancy on the response of lymphocytes from the primary lymphoid organs to mitogenic and alloantigenic stimulation was investigated. Thymocytes and bone marrow cells from gravid animals were found to exhibit elevated reactivity to T cell mitogens and allogeneic stimulator cells. In contrast, the LPS response of bone marrow cells from pregnant mice did not differ significantly from that of virgin animals. These findings indicate that the immune reactivity of T cells derived from the primary lymphoid organs is altered during syngeneic murine pregnancy. Pregnancy-induced modifications in T lymphocyte reactivity may contribute to the ability of the maternal immune system to recognize and react against fetal antigens.

Original language	English
Pages (from-to)	365-369
Number of pages	5
Journal	Journal of Reproductive Immunology
Volume	7
Issue number	4
DOIs	https://doi.org/10.1016/0165-0378(85)90031-2
Publication status	Published - Jun 1985
Externally published	Yes

Bibliographical note

Funding Information:
This work is supported by grants crom the National Cancer Institute of Canada and the Medical Research Council of Canada (MT-6470). D.W.H. is the recipient of a fellowship from the Medical Research Council of Canada.

ASJC Scopus Subject Areas

Immunology and Allergy
Immunology
Reproductive Medicine
Obstetrics and Gynaecology

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10.1016/0165-0378(85)90031-2

Cite this

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title = "Altered mitogen- and alloantigen-induced lymphoproliferative responses in primary lymphoid organs of pregnant mice",

abstract = "The effect of syngeneic murine pregnancy on the response of lymphocytes from the primary lymphoid organs to mitogenic and alloantigenic stimulation was investigated. Thymocytes and bone marrow cells from gravid animals were found to exhibit elevated reactivity to T cell mitogens and allogeneic stimulator cells. In contrast, the LPS response of bone marrow cells from pregnant mice did not differ significantly from that of virgin animals. These findings indicate that the immune reactivity of T cells derived from the primary lymphoid organs is altered during syngeneic murine pregnancy. Pregnancy-induced modifications in T lymphocyte reactivity may contribute to the ability of the maternal immune system to recognize and react against fetal antigens.",

author = "Hoskin, {D. W.} and Murgita, {R. A.}",

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year = "1985",

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doi = "10.1016/0165-0378(85)90031-2",

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T1 - Altered mitogen- and alloantigen-induced lymphoproliferative responses in primary lymphoid organs of pregnant mice

AU - Hoskin, D. W.

AU - Murgita, R. A.

N1 - Funding Information: This work is supported by grants crom the National Cancer Institute of Canada and the Medical Research Council of Canada (MT-6470). D.W.H. is the recipient of a fellowship from the Medical Research Council of Canada.

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N2 - The effect of syngeneic murine pregnancy on the response of lymphocytes from the primary lymphoid organs to mitogenic and alloantigenic stimulation was investigated. Thymocytes and bone marrow cells from gravid animals were found to exhibit elevated reactivity to T cell mitogens and allogeneic stimulator cells. In contrast, the LPS response of bone marrow cells from pregnant mice did not differ significantly from that of virgin animals. These findings indicate that the immune reactivity of T cells derived from the primary lymphoid organs is altered during syngeneic murine pregnancy. Pregnancy-induced modifications in T lymphocyte reactivity may contribute to the ability of the maternal immune system to recognize and react against fetal antigens.

AB - The effect of syngeneic murine pregnancy on the response of lymphocytes from the primary lymphoid organs to mitogenic and alloantigenic stimulation was investigated. Thymocytes and bone marrow cells from gravid animals were found to exhibit elevated reactivity to T cell mitogens and allogeneic stimulator cells. In contrast, the LPS response of bone marrow cells from pregnant mice did not differ significantly from that of virgin animals. These findings indicate that the immune reactivity of T cells derived from the primary lymphoid organs is altered during syngeneic murine pregnancy. Pregnancy-induced modifications in T lymphocyte reactivity may contribute to the ability of the maternal immune system to recognize and react against fetal antigens.

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Altered mitogen- and alloantigen-induced lymphoproliferative responses in primary lymphoid organs of pregnant mice

Abstract

Bibliographical note

ASJC Scopus Subject Areas

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