Altered mitogen- and alloantigen-induced lymphoproliferative responses in primary lymphoid organs of pregnant mice

D. W. Hoskin, R. A. Murgita

Producción científica: Contribución a una revistaArtículorevisión exhaustiva

5 Citas (Scopus)

Resumen

The effect of syngeneic murine pregnancy on the response of lymphocytes from the primary lymphoid organs to mitogenic and alloantigenic stimulation was investigated. Thymocytes and bone marrow cells from gravid animals were found to exhibit elevated reactivity to T cell mitogens and allogeneic stimulator cells. In contrast, the LPS response of bone marrow cells from pregnant mice did not differ significantly from that of virgin animals. These findings indicate that the immune reactivity of T cells derived from the primary lymphoid organs is altered during syngeneic murine pregnancy. Pregnancy-induced modifications in T lymphocyte reactivity may contribute to the ability of the maternal immune system to recognize and react against fetal antigens.

Idioma originalEnglish
Páginas (desde-hasta)365-369
Número de páginas5
PublicaciónJournal of Reproductive Immunology
Volumen7
N.º4
DOI
EstadoPublished - jun. 1985
Publicado de forma externa

Nota bibliográfica

Funding Information:
This work is supported by grants crom the National Cancer Institute of Canada and the Medical Research Council of Canada (MT-6470). D.W.H. is the recipient of a fellowship from the Medical Research Council of Canada.

ASJC Scopus Subject Areas

  • Immunology and Allergy
  • Immunology
  • Reproductive Medicine
  • Obstetrics and Gynaecology

Huella

Profundice en los temas de investigación de 'Altered mitogen- and alloantigen-induced lymphoproliferative responses in primary lymphoid organs of pregnant mice'. En conjunto forman una huella única.

Citar esto