Antiviral Chinese medicinal herbs against respiratory syncytial virus

Shuang Cheng Ma; Jiang Du; Paul Pui Hay But; Xue Long Deng; Yong Wen Zhang; Vincent Eng Choon Ooi; Hong Xi Xu; Spencer Hon Sun Lee; Song Fong Lee

doi:10.1016/S0378-8741(01)00389-0

Antiviral Chinese medicinal herbs against respiratory syncytial virus

Shuang Cheng Ma, Jiang Du, Paul Pui Hay But, Xue Long Deng, Yong Wen Zhang, Vincent Eng Choon Ooi, Hong Xi Xu, Spencer Hon Sun Lee, Song Fong Lee

Medicine

Research output: Contribution to journal › Article › peer-review

271 Citations (Scopus)

Abstract

Forty-four medicinal herbs were tested for antiviral activities against respiratory syncytial virus (RSV) by means of the cytopathologic effect (CPE) assay. Twenty-seven of the 44 medicinal herbs showed potent or moderate antiviral activities against RSV with 50% inhibition concentration (IC₅₀) ranging from 6.3 to 52.1 μg/ml, and with selectivity index (SI) ranging from 2.0 to 32.1. Further purification of the active extracts from Sophora flavescens Ait. and Scutellaria baicalensis Georgi led to the identification of anagyrine (2), oxymatrine (7), sophoranol (10), wogonin (12), and oroxylin A (13) as the potent anti-RSV components.

Original language	English
Pages (from-to)	205-211
Number of pages	7
Journal	Journal of Ethnopharmacology
Volume	79
Issue number	2
DOIs	https://doi.org/10.1016/S0378-8741(01)00389-0
Publication status	Published - 2002

Bibliographical note

Funding Information:
Partial support was received from Industrial Support Fund (AF/281/97) and Research Grants Council (CUHK 4171/99M). Technical assistance from Hua WANG is deeply appreciated.

ASJC Scopus Subject Areas

Pharmacology
Drug Discovery

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10.1016/S0378-8741(01)00389-0

Cite this

@article{172aba3544f942259b7c9042e2038659,

title = "Antiviral Chinese medicinal herbs against respiratory syncytial virus",

abstract = "Forty-four medicinal herbs were tested for antiviral activities against respiratory syncytial virus (RSV) by means of the cytopathologic effect (CPE) assay. Twenty-seven of the 44 medicinal herbs showed potent or moderate antiviral activities against RSV with 50% inhibition concentration (IC50) ranging from 6.3 to 52.1 μg/ml, and with selectivity index (SI) ranging from 2.0 to 32.1. Further purification of the active extracts from Sophora flavescens Ait. and Scutellaria baicalensis Georgi led to the identification of anagyrine (2), oxymatrine (7), sophoranol (10), wogonin (12), and oroxylin A (13) as the potent anti-RSV components.",

author = "Ma, {Shuang Cheng} and Jiang Du and But, {Paul Pui Hay} and Deng, {Xue Long} and Zhang, {Yong Wen} and Ooi, {Vincent Eng Choon} and Xu, {Hong Xi} and Lee, {Spencer Hon Sun} and Lee, {Song Fong}",

note = "Funding Information: Partial support was received from Industrial Support Fund (AF/281/97) and Research Grants Council (CUHK 4171/99M). Technical assistance from Hua WANG is deeply appreciated.",

year = "2002",

doi = "10.1016/S0378-8741(01)00389-0",

language = "English",

volume = "79",

pages = "205--211",

journal = "Journal of Ethnopharmacology",

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TY - JOUR

T1 - Antiviral Chinese medicinal herbs against respiratory syncytial virus

AU - Ma, Shuang Cheng

AU - Du, Jiang

AU - But, Paul Pui Hay

AU - Deng, Xue Long

AU - Zhang, Yong Wen

AU - Ooi, Vincent Eng Choon

AU - Xu, Hong Xi

AU - Lee, Spencer Hon Sun

AU - Lee, Song Fong

N1 - Funding Information: Partial support was received from Industrial Support Fund (AF/281/97) and Research Grants Council (CUHK 4171/99M). Technical assistance from Hua WANG is deeply appreciated.

PY - 2002

Y1 - 2002

N2 - Forty-four medicinal herbs were tested for antiviral activities against respiratory syncytial virus (RSV) by means of the cytopathologic effect (CPE) assay. Twenty-seven of the 44 medicinal herbs showed potent or moderate antiviral activities against RSV with 50% inhibition concentration (IC50) ranging from 6.3 to 52.1 μg/ml, and with selectivity index (SI) ranging from 2.0 to 32.1. Further purification of the active extracts from Sophora flavescens Ait. and Scutellaria baicalensis Georgi led to the identification of anagyrine (2), oxymatrine (7), sophoranol (10), wogonin (12), and oroxylin A (13) as the potent anti-RSV components.

AB - Forty-four medicinal herbs were tested for antiviral activities against respiratory syncytial virus (RSV) by means of the cytopathologic effect (CPE) assay. Twenty-seven of the 44 medicinal herbs showed potent or moderate antiviral activities against RSV with 50% inhibition concentration (IC50) ranging from 6.3 to 52.1 μg/ml, and with selectivity index (SI) ranging from 2.0 to 32.1. Further purification of the active extracts from Sophora flavescens Ait. and Scutellaria baicalensis Georgi led to the identification of anagyrine (2), oxymatrine (7), sophoranol (10), wogonin (12), and oroxylin A (13) as the potent anti-RSV components.

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Antiviral Chinese medicinal herbs against respiratory syncytial virus

Abstract

Bibliographical note

ASJC Scopus Subject Areas

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