TY - JOUR
T1 - Antiviral Chinese medicinal herbs against respiratory syncytial virus
AU - Ma, Shuang Cheng
AU - Du, Jiang
AU - But, Paul Pui Hay
AU - Deng, Xue Long
AU - Zhang, Yong Wen
AU - Ooi, Vincent Eng Choon
AU - Xu, Hong Xi
AU - Lee, Spencer Hon Sun
AU - Lee, Song Fong
N1 - Funding Information:
Partial support was received from Industrial Support Fund (AF/281/97) and Research Grants Council (CUHK 4171/99M). Technical assistance from Hua WANG is deeply appreciated.
PY - 2002
Y1 - 2002
N2 - Forty-four medicinal herbs were tested for antiviral activities against respiratory syncytial virus (RSV) by means of the cytopathologic effect (CPE) assay. Twenty-seven of the 44 medicinal herbs showed potent or moderate antiviral activities against RSV with 50% inhibition concentration (IC50) ranging from 6.3 to 52.1 μg/ml, and with selectivity index (SI) ranging from 2.0 to 32.1. Further purification of the active extracts from Sophora flavescens Ait. and Scutellaria baicalensis Georgi led to the identification of anagyrine (2), oxymatrine (7), sophoranol (10), wogonin (12), and oroxylin A (13) as the potent anti-RSV components.
AB - Forty-four medicinal herbs were tested for antiviral activities against respiratory syncytial virus (RSV) by means of the cytopathologic effect (CPE) assay. Twenty-seven of the 44 medicinal herbs showed potent or moderate antiviral activities against RSV with 50% inhibition concentration (IC50) ranging from 6.3 to 52.1 μg/ml, and with selectivity index (SI) ranging from 2.0 to 32.1. Further purification of the active extracts from Sophora flavescens Ait. and Scutellaria baicalensis Georgi led to the identification of anagyrine (2), oxymatrine (7), sophoranol (10), wogonin (12), and oroxylin A (13) as the potent anti-RSV components.
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U2 - 10.1016/S0378-8741(01)00389-0
DO - 10.1016/S0378-8741(01)00389-0
M3 - Article
C2 - 11801383
AN - SCOPUS:0036166889
SN - 0378-8741
VL - 79
SP - 205
EP - 211
JO - Journal of Ethnopharmacology
JF - Journal of Ethnopharmacology
IS - 2
ER -