Artefactual decrease in total protein concentration in patients with monoclonal gammopathies: A method-dependent error

Karen J. Whitlow; Amin A. Nanji; Morris R. Pudek

doi:10.1016/S0009-9120(84)90123-1

Artefactual decrease in total protein concentration in patients with monoclonal gammopathies: A method-dependent error

Karen J. Whitlow, Amin A. Nanji, Morris R. Pudek

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

We found total protein estimates in patients with monoclonal gammopathies to be erroneously low when using the Cobas-Bio^R centrifugal analyzer. This problem occurred only when a serum-water blank was used. This probably results from the precipitation of these proteins under conditions of low ionic strength resulting in high blank readings. The problem can be avoided if a serum-saline blank is used.

Original language	English
Pages (from-to)	233-235
Number of pages	3
Journal	Clinical Biochemistry
Volume	17
Issue number	4
DOIs	https://doi.org/10.1016/S0009-9120(84)90123-1
Publication status	Published - Aug 1984
Externally published	Yes

ASJC Scopus Subject Areas

Clinical Biochemistry

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10.1016/S0009-9120(84)90123-1

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title = "Artefactual decrease in total protein concentration in patients with monoclonal gammopathies: A method-dependent error",

abstract = "We found total protein estimates in patients with monoclonal gammopathies to be erroneously low when using the Cobas-BioR centrifugal analyzer. This problem occurred only when a serum-water blank was used. This probably results from the precipitation of these proteins under conditions of low ionic strength resulting in high blank readings. The problem can be avoided if a serum-saline blank is used.",

author = "Whitlow, {Karen J.} and Nanji, {Amin A.} and Pudek, {Morris R.}",

year = "1984",

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AU - Nanji, Amin A.

AU - Pudek, Morris R.

PY - 1984/8

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N2 - We found total protein estimates in patients with monoclonal gammopathies to be erroneously low when using the Cobas-BioR centrifugal analyzer. This problem occurred only when a serum-water blank was used. This probably results from the precipitation of these proteins under conditions of low ionic strength resulting in high blank readings. The problem can be avoided if a serum-saline blank is used.

AB - We found total protein estimates in patients with monoclonal gammopathies to be erroneously low when using the Cobas-BioR centrifugal analyzer. This problem occurred only when a serum-water blank was used. This probably results from the precipitation of these proteins under conditions of low ionic strength resulting in high blank readings. The problem can be avoided if a serum-saline blank is used.

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ER -

Artefactual decrease in total protein concentration in patients with monoclonal gammopathies: A method-dependent error

Abstract

ASJC Scopus Subject Areas

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