Artefactual decrease in total protein concentration in patients with monoclonal gammopathies: A method-dependent error

Karen J. Whitlow; Amin A. Nanji; Morris R. Pudek

doi:10.1016/S0009-9120(84)90123-1

Artefactual decrease in total protein concentration in patients with monoclonal gammopathies: A method-dependent error

Karen J. Whitlow, Amin A. Nanji, Morris R. Pudek

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3 Citations (Scopus)

Résumé

We found total protein estimates in patients with monoclonal gammopathies to be erroneously low when using the Cobas-Bio^R centrifugal analyzer. This problem occurred only when a serum-water blank was used. This probably results from the precipitation of these proteins under conditions of low ionic strength resulting in high blank readings. The problem can be avoided if a serum-saline blank is used.

Langue d'origine	English
Pages (de-à)	233-235
Nombre de pages	3
Journal	Clinical Biochemistry
Volume	17
Numéro de publication	4
DOI	https://doi.org/10.1016/S0009-9120(84)90123-1
Statut de publication	Published - août 1984
Publié à l'externe	Oui

ASJC Scopus Subject Areas

Clinical Biochemistry

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10.1016/S0009-9120(84)90123-1

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abstract = "We found total protein estimates in patients with monoclonal gammopathies to be erroneously low when using the Cobas-BioR centrifugal analyzer. This problem occurred only when a serum-water blank was used. This probably results from the precipitation of these proteins under conditions of low ionic strength resulting in high blank readings. The problem can be avoided if a serum-saline blank is used.",

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AB - We found total protein estimates in patients with monoclonal gammopathies to be erroneously low when using the Cobas-BioR centrifugal analyzer. This problem occurred only when a serum-water blank was used. This probably results from the precipitation of these proteins under conditions of low ionic strength resulting in high blank readings. The problem can be avoided if a serum-saline blank is used.

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Artefactual decrease in total protein concentration in patients with monoclonal gammopathies: A method-dependent error

Résumé

ASJC Scopus Subject Areas

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