Biotransformation/Metabolism

J. L. Rourke; C. J. Sinal

doi:10.1016/B978-0-12-386454-3.00007-5

Biotransformation/Metabolism

J. L. Rourke, C. J. Sinal

Medicine

Research output: Chapter in Book/Report/Conference proceeding › Chapter

9 Citations (Scopus)

Abstract

This article provides an introduction to the topic of biotransformation. Biotransformation refers to the process by which xenobiotic (foreign) or endogenous chemicals are enzymatically modified (metabolized) to chemicals that differ in their excretability (hydrophobic vs hydrophilic), biological activity (activation vs deactivation), and toxicity (detoxication vs toxication). These biotransformation pathways are broadly classified as phase I and phase II, based on the nature of the chemical modification and the enzymes involved. In this article, key concepts are introduced and examples of toxicologically relevant biotransformation reactions are provided.

Original language	English
Title of host publication	Encyclopedia of Toxicology
Subtitle of host publication	Third Edition
Publisher	Elsevier
Pages	490-502
Number of pages	13
ISBN (Electronic)	9780123864543
ISBN (Print)	9780123864550
DOIs	https://doi.org/10.1016/B978-0-12-386454-3.00007-5
Publication status	Published - Jan 1 2014

Bibliographical note

Publisher Copyright:
© 2014 Elsevier Inc. All rights reserved.

ASJC Scopus Subject Areas

General Medicine

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10.1016/B978-0-12-386454-3.00007-5

Cite this

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AB - This article provides an introduction to the topic of biotransformation. Biotransformation refers to the process by which xenobiotic (foreign) or endogenous chemicals are enzymatically modified (metabolized) to chemicals that differ in their excretability (hydrophobic vs hydrophilic), biological activity (activation vs deactivation), and toxicity (detoxication vs toxication). These biotransformation pathways are broadly classified as phase I and phase II, based on the nature of the chemical modification and the enzymes involved. In this article, key concepts are introduced and examples of toxicologically relevant biotransformation reactions are provided.

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Biotransformation/Metabolism

Abstract

Bibliographical note

ASJC Scopus Subject Areas

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