Biotransformation/Metabolism

J. L. Rourke; C. J. Sinal

doi:10.1016/B978-0-12-386454-3.00007-5

Biotransformation/Metabolism

J. L. Rourke, C. J. Sinal

Medicine

Résultat de recherche: Chapter

9 Citations (Scopus)

Résumé

This article provides an introduction to the topic of biotransformation. Biotransformation refers to the process by which xenobiotic (foreign) or endogenous chemicals are enzymatically modified (metabolized) to chemicals that differ in their excretability (hydrophobic vs hydrophilic), biological activity (activation vs deactivation), and toxicity (detoxication vs toxication). These biotransformation pathways are broadly classified as phase I and phase II, based on the nature of the chemical modification and the enzymes involved. In this article, key concepts are introduced and examples of toxicologically relevant biotransformation reactions are provided.

Langue d'origine	English
Titre de la publication principale	Encyclopedia of Toxicology
Sous-titre de la publication principale	Third Edition
Maison d'édition	Elsevier
Pages	490-502
Nombre de pages	13
ISBN (électronique)	9780123864543
ISBN (imprimé)	9780123864550
DOI	https://doi.org/10.1016/B978-0-12-386454-3.00007-5
Statut de publication	Published - janv. 1 2014

Note bibliographique

Publisher Copyright:
© 2014 Elsevier Inc. All rights reserved.

ASJC Scopus Subject Areas

General Medicine

Accès au document

10.1016/B978-0-12-386454-3.00007-5

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Biotransformation/Metabolism

Résumé

Note bibliographique

ASJC Scopus Subject Areas

Accès au document

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Empreinte numérique

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