Breach delivery: Increased solute uptake points to a defective skin barrier in atopic dermatitis

W. H. Irwin McLean; Peter R. Hull

doi:10.1038/sj.jid.5700609

Breach delivery: Increased solute uptake points to a defective skin barrier in atopic dermatitis

W. H. Irwin McLean, Peter R. Hull

Research output: Contribution to journal › Comment/debate › peer-review

28 Citations (Scopus)

Abstract

Evidence is now emerging for enhanced penetration of chemical solutes into uninvolved skin of atopic dermatitis patients. Along with the recent discovery of prevalent null mutations in the gene encoding filaggrin, a protein essential for stratum corneum formation, these data point to an innate epidermal-barrier defect in atopy.

Original language	English
Pages (from-to)	8-10
Number of pages	3
Journal	Journal of Investigative Dermatology
Volume	127
Issue number	1
DOIs	https://doi.org/10.1038/sj.jid.5700609
Publication status	Published - Jan 27 2007
Externally published	Yes

ASJC Scopus Subject Areas

Biochemistry
Molecular Biology
Dermatology
Cell Biology

PubMed: MeSH publication types

Journal Article
Comment

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10.1038/sj.jid.5700609

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abstract = "Evidence is now emerging for enhanced penetration of chemical solutes into uninvolved skin of atopic dermatitis patients. Along with the recent discovery of prevalent null mutations in the gene encoding filaggrin, a protein essential for stratum corneum formation, these data point to an innate epidermal-barrier defect in atopy.",

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Breach delivery: Increased solute uptake points to a defective skin barrier in atopic dermatitis

Abstract

ASJC Scopus Subject Areas

PubMed: MeSH publication types

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