Cannabinoid receptor 1 inhibition causes seizures during anesthesia induction in experimental sepsis

Inga Küster; Rieke Kuschnereit; Melanie Kelly; Juan Zhou; Sara Whynot; Mandana Kianian; Orlando Hung; Romesh Shukla; Vladimir Cerny; Dragan Pavlovic; Christian Lehmann

doi:10.1213/ANE.0b013e318251dada

Cannabinoid receptor 1 inhibition causes seizures during anesthesia induction in experimental sepsis

Inga Küster, Rieke Kuschnereit, Melanie Kelly, Juan Zhou, Sara Whynot, Mandana Kianian, Orlando Hung, Romesh Shukla, Vladimir Cerny, Dragan Pavlovic, Christian Lehmann

Medicine

Medicine

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

We report on seizures during anesthesia induction in animals treated with a cannabinoid receptor 1 (CB1R) antagonist for experimental sepsis. Animals received surgery for colon ascendens stent peritonitis-induced sepsis or sham surgery followed by treatment of CB1R antagonist, CB1R agonist, or placebo. Fourteen hours later, animals received pentobarbital or ketamine for anesthesia induction and animal behavior was observed. Tonic-clonic seizures were observed in 5 of 12 septic animals (42%) treated with CB1R antagonist after induction of anesthesia with pentobarbital. The data suggest that CB1R inhibition in combination with pentobarbital may increase the incidence of anesthetic-induced seizures in the case of sepsis.

Original language	English
Pages (from-to)	1217-1219
Number of pages	3
Journal	Anesthesia and Analgesia
Volume	114
Issue number	6
DOIs	https://doi.org/10.1213/ANE.0b013e318251dada
Publication status	Published - Jun 2012

ASJC Scopus Subject Areas

Anesthesiology and Pain Medicine

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title = "Cannabinoid receptor 1 inhibition causes seizures during anesthesia induction in experimental sepsis",

abstract = "We report on seizures during anesthesia induction in animals treated with a cannabinoid receptor 1 (CB1R) antagonist for experimental sepsis. Animals received surgery for colon ascendens stent peritonitis-induced sepsis or sham surgery followed by treatment of CB1R antagonist, CB1R agonist, or placebo. Fourteen hours later, animals received pentobarbital or ketamine for anesthesia induction and animal behavior was observed. Tonic-clonic seizures were observed in 5 of 12 septic animals (42%) treated with CB1R antagonist after induction of anesthesia with pentobarbital. The data suggest that CB1R inhibition in combination with pentobarbital may increase the incidence of anesthetic-induced seizures in the case of sepsis.",

author = "Inga K{\"u}ster and Rieke Kuschnereit and Melanie Kelly and Juan Zhou and Sara Whynot and Mandana Kianian and Orlando Hung and Romesh Shukla and Vladimir Cerny and Dragan Pavlovic and Christian Lehmann",

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T1 - Cannabinoid receptor 1 inhibition causes seizures during anesthesia induction in experimental sepsis

AU - Küster, Inga

AU - Kuschnereit, Rieke

AU - Kelly, Melanie

AU - Zhou, Juan

AU - Whynot, Sara

AU - Kianian, Mandana

AU - Hung, Orlando

AU - Shukla, Romesh

AU - Cerny, Vladimir

AU - Pavlovic, Dragan

AU - Lehmann, Christian

PY - 2012/6

Y1 - 2012/6

N2 - We report on seizures during anesthesia induction in animals treated with a cannabinoid receptor 1 (CB1R) antagonist for experimental sepsis. Animals received surgery for colon ascendens stent peritonitis-induced sepsis or sham surgery followed by treatment of CB1R antagonist, CB1R agonist, or placebo. Fourteen hours later, animals received pentobarbital or ketamine for anesthesia induction and animal behavior was observed. Tonic-clonic seizures were observed in 5 of 12 septic animals (42%) treated with CB1R antagonist after induction of anesthesia with pentobarbital. The data suggest that CB1R inhibition in combination with pentobarbital may increase the incidence of anesthetic-induced seizures in the case of sepsis.

AB - We report on seizures during anesthesia induction in animals treated with a cannabinoid receptor 1 (CB1R) antagonist for experimental sepsis. Animals received surgery for colon ascendens stent peritonitis-induced sepsis or sham surgery followed by treatment of CB1R antagonist, CB1R agonist, or placebo. Fourteen hours later, animals received pentobarbital or ketamine for anesthesia induction and animal behavior was observed. Tonic-clonic seizures were observed in 5 of 12 septic animals (42%) treated with CB1R antagonist after induction of anesthesia with pentobarbital. The data suggest that CB1R inhibition in combination with pentobarbital may increase the incidence of anesthetic-induced seizures in the case of sepsis.

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Cannabinoid receptor 1 inhibition causes seizures during anesthesia induction in experimental sepsis

Abstract

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