TY - JOUR
T1 - Cannabinoid receptor 1 inhibition causes seizures during anesthesia induction in experimental sepsis
AU - Küster, Inga
AU - Kuschnereit, Rieke
AU - Kelly, Melanie
AU - Zhou, Juan
AU - Whynot, Sara
AU - Kianian, Mandana
AU - Hung, Orlando
AU - Shukla, Romesh
AU - Cerny, Vladimir
AU - Pavlovic, Dragan
AU - Lehmann, Christian
PY - 2012/6
Y1 - 2012/6
N2 - We report on seizures during anesthesia induction in animals treated with a cannabinoid receptor 1 (CB1R) antagonist for experimental sepsis. Animals received surgery for colon ascendens stent peritonitis-induced sepsis or sham surgery followed by treatment of CB1R antagonist, CB1R agonist, or placebo. Fourteen hours later, animals received pentobarbital or ketamine for anesthesia induction and animal behavior was observed. Tonic-clonic seizures were observed in 5 of 12 septic animals (42%) treated with CB1R antagonist after induction of anesthesia with pentobarbital. The data suggest that CB1R inhibition in combination with pentobarbital may increase the incidence of anesthetic-induced seizures in the case of sepsis.
AB - We report on seizures during anesthesia induction in animals treated with a cannabinoid receptor 1 (CB1R) antagonist for experimental sepsis. Animals received surgery for colon ascendens stent peritonitis-induced sepsis or sham surgery followed by treatment of CB1R antagonist, CB1R agonist, or placebo. Fourteen hours later, animals received pentobarbital or ketamine for anesthesia induction and animal behavior was observed. Tonic-clonic seizures were observed in 5 of 12 septic animals (42%) treated with CB1R antagonist after induction of anesthesia with pentobarbital. The data suggest that CB1R inhibition in combination with pentobarbital may increase the incidence of anesthetic-induced seizures in the case of sepsis.
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UR - http://www.scopus.com/inward/citedby.url?scp=84861527610&partnerID=8YFLogxK
U2 - 10.1213/ANE.0b013e318251dada
DO - 10.1213/ANE.0b013e318251dada
M3 - Article
C2 - 22504215
AN - SCOPUS:84861527610
SN - 0003-2999
VL - 114
SP - 1217
EP - 1219
JO - Anesthesia and Analgesia
JF - Anesthesia and Analgesia
IS - 6
ER -