D-band strain underestimates fibril strain for twisted collagen fibrils at low strains

Matthew P. Leighton; Andrew D. Rutenberg; Laurent Kreplak

doi:10.1016/j.jmbbm.2021.104854

D-band strain underestimates fibril strain for twisted collagen fibrils at low strains

Matthew P. Leighton, Andrew D. Rutenberg, Laurent Kreplak

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

Collagen fibrils are the main structural component of load-bearing tissues such as tendons, ligaments, skin, the cornea of the eye, and the heart. The D-band of collagen fibrils is an axial periodic density modulation that can be easily characterized by tissue-level X-ray scattering. During mechanical testing, D-band strain is often used as a proxy for fibril strain. However, this approach ignores the coupling between strain and molecular tilt. We examine the validity of this approximation using an elastomeric collagen fibril model that includes both the D-band and a molecular tilt field. In the low strain regime, we show that the D-band strain substantially underestimates fibril strain for strongly twisted collagen fibrils — such as fibrils from skin or corneal tissue.

Original language	English
Article number	104854
Journal	Journal of the Mechanical Behavior of Biomedical Materials
Volume	124
DOIs	https://doi.org/10.1016/j.jmbbm.2021.104854
Publication status	Published - Dec 2021

Bibliographical note

Funding Information:
We thank the Natural Sciences and Engineering Research Council of Canada (NSERC) for operating Grants RGPIN-2018-03781 (LK) and RGPIN-2019-05888 (ADR). MPL thanks NSERC for summer fellowship support ( USRA-552365-2020 ), and a CGS Masters fellowship .

Publisher Copyright:
© 2021 Elsevier Ltd

ASJC Scopus Subject Areas

Biomaterials
Biomedical Engineering
Mechanics of Materials

PubMed: MeSH publication types

Journal Article
Research Support, Non-U.S. Gov't

Access to Document

10.1016/j.jmbbm.2021.104854

Cite this

@article{369463df52e04f47b3978cfe57042237,

title = "D-band strain underestimates fibril strain for twisted collagen fibrils at low strains",

abstract = "Collagen fibrils are the main structural component of load-bearing tissues such as tendons, ligaments, skin, the cornea of the eye, and the heart. The D-band of collagen fibrils is an axial periodic density modulation that can be easily characterized by tissue-level X-ray scattering. During mechanical testing, D-band strain is often used as a proxy for fibril strain. However, this approach ignores the coupling between strain and molecular tilt. We examine the validity of this approximation using an elastomeric collagen fibril model that includes both the D-band and a molecular tilt field. In the low strain regime, we show that the D-band strain substantially underestimates fibril strain for strongly twisted collagen fibrils — such as fibrils from skin or corneal tissue.",

author = "Leighton, {Matthew P.} and Rutenberg, {Andrew D.} and Laurent Kreplak",

note = "Funding Information: We thank the Natural Sciences and Engineering Research Council of Canada (NSERC) for operating Grants RGPIN-2018-03781 (LK) and RGPIN-2019-05888 (ADR). MPL thanks NSERC for summer fellowship support ( USRA-552365-2020 ), and a CGS Masters fellowship . Publisher Copyright: {\textcopyright} 2021 Elsevier Ltd",

year = "2021",

month = dec,

doi = "10.1016/j.jmbbm.2021.104854",

language = "English",

volume = "124",

journal = "Journal of the Mechanical Behavior of Biomedical Materials",

issn = "1751-6161",

publisher = "Elsevier BV",

}

TY - JOUR

T1 - D-band strain underestimates fibril strain for twisted collagen fibrils at low strains

AU - Leighton, Matthew P.

AU - Rutenberg, Andrew D.

AU - Kreplak, Laurent

N1 - Funding Information: We thank the Natural Sciences and Engineering Research Council of Canada (NSERC) for operating Grants RGPIN-2018-03781 (LK) and RGPIN-2019-05888 (ADR). MPL thanks NSERC for summer fellowship support ( USRA-552365-2020 ), and a CGS Masters fellowship . Publisher Copyright: © 2021 Elsevier Ltd

PY - 2021/12

Y1 - 2021/12

N2 - Collagen fibrils are the main structural component of load-bearing tissues such as tendons, ligaments, skin, the cornea of the eye, and the heart. The D-band of collagen fibrils is an axial periodic density modulation that can be easily characterized by tissue-level X-ray scattering. During mechanical testing, D-band strain is often used as a proxy for fibril strain. However, this approach ignores the coupling between strain and molecular tilt. We examine the validity of this approximation using an elastomeric collagen fibril model that includes both the D-band and a molecular tilt field. In the low strain regime, we show that the D-band strain substantially underestimates fibril strain for strongly twisted collagen fibrils — such as fibrils from skin or corneal tissue.

AB - Collagen fibrils are the main structural component of load-bearing tissues such as tendons, ligaments, skin, the cornea of the eye, and the heart. The D-band of collagen fibrils is an axial periodic density modulation that can be easily characterized by tissue-level X-ray scattering. During mechanical testing, D-band strain is often used as a proxy for fibril strain. However, this approach ignores the coupling between strain and molecular tilt. We examine the validity of this approximation using an elastomeric collagen fibril model that includes both the D-band and a molecular tilt field. In the low strain regime, we show that the D-band strain substantially underestimates fibril strain for strongly twisted collagen fibrils — such as fibrils from skin or corneal tissue.

UR - http://www.scopus.com/inward/record.url?scp=85116036862&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85116036862&partnerID=8YFLogxK

U2 - 10.1016/j.jmbbm.2021.104854

DO - 10.1016/j.jmbbm.2021.104854

M3 - Article

C2 - 34601435

AN - SCOPUS:85116036862

SN - 1751-6161

VL - 124

JO - Journal of the Mechanical Behavior of Biomedical Materials

JF - Journal of the Mechanical Behavior of Biomedical Materials

M1 - 104854

ER -

D-band strain underestimates fibril strain for twisted collagen fibrils at low strains

Abstract

Bibliographical note

ASJC Scopus Subject Areas

PubMed: MeSH publication types

Access to Document

Other files and links

Fingerprint

Cite this