D-band strain underestimates fibril strain for twisted collagen fibrils at low strains

Matthew P. Leighton; Andrew D. Rutenberg; Laurent Kreplak

doi:10.1016/j.jmbbm.2021.104854

D-band strain underestimates fibril strain for twisted collagen fibrils at low strains

Matthew P. Leighton, Andrew D. Rutenberg, Laurent Kreplak

Producción científica: Contribución a una revista › Artículo › revisión exhaustiva

7 Citas (Scopus)

Resumen

Collagen fibrils are the main structural component of load-bearing tissues such as tendons, ligaments, skin, the cornea of the eye, and the heart. The D-band of collagen fibrils is an axial periodic density modulation that can be easily characterized by tissue-level X-ray scattering. During mechanical testing, D-band strain is often used as a proxy for fibril strain. However, this approach ignores the coupling between strain and molecular tilt. We examine the validity of this approximation using an elastomeric collagen fibril model that includes both the D-band and a molecular tilt field. In the low strain regime, we show that the D-band strain substantially underestimates fibril strain for strongly twisted collagen fibrils — such as fibrils from skin or corneal tissue.

Idioma original	English
Número de artículo	104854
Publicación	Journal of the Mechanical Behavior of Biomedical Materials
Volumen	124
DOI	https://doi.org/10.1016/j.jmbbm.2021.104854
Estado	Published - dic. 2021

Nota bibliográfica

Funding Information:
We thank the Natural Sciences and Engineering Research Council of Canada (NSERC) for operating Grants RGPIN-2018-03781 (LK) and RGPIN-2019-05888 (ADR). MPL thanks NSERC for summer fellowship support ( USRA-552365-2020 ), and a CGS Masters fellowship .

Publisher Copyright:
© 2021 Elsevier Ltd

ASJC Scopus Subject Areas

Biomaterials
Biomedical Engineering
Mechanics of Materials

PubMed: MeSH publication types

Journal Article
Research Support, Non-U.S. Gov't

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title = "D-band strain underestimates fibril strain for twisted collagen fibrils at low strains",

abstract = "Collagen fibrils are the main structural component of load-bearing tissues such as tendons, ligaments, skin, the cornea of the eye, and the heart. The D-band of collagen fibrils is an axial periodic density modulation that can be easily characterized by tissue-level X-ray scattering. During mechanical testing, D-band strain is often used as a proxy for fibril strain. However, this approach ignores the coupling between strain and molecular tilt. We examine the validity of this approximation using an elastomeric collagen fibril model that includes both the D-band and a molecular tilt field. In the low strain regime, we show that the D-band strain substantially underestimates fibril strain for strongly twisted collagen fibrils — such as fibrils from skin or corneal tissue.",

author = "Leighton, {Matthew P.} and Rutenberg, {Andrew D.} and Laurent Kreplak",

note = "Funding Information: We thank the Natural Sciences and Engineering Research Council of Canada (NSERC) for operating Grants RGPIN-2018-03781 (LK) and RGPIN-2019-05888 (ADR). MPL thanks NSERC for summer fellowship support ( USRA-552365-2020 ), and a CGS Masters fellowship . Publisher Copyright: {\textcopyright} 2021 Elsevier Ltd",

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AU - Leighton, Matthew P.

AU - Rutenberg, Andrew D.

AU - Kreplak, Laurent

N1 - Funding Information: We thank the Natural Sciences and Engineering Research Council of Canada (NSERC) for operating Grants RGPIN-2018-03781 (LK) and RGPIN-2019-05888 (ADR). MPL thanks NSERC for summer fellowship support ( USRA-552365-2020 ), and a CGS Masters fellowship . Publisher Copyright: © 2021 Elsevier Ltd

PY - 2021/12

Y1 - 2021/12

N2 - Collagen fibrils are the main structural component of load-bearing tissues such as tendons, ligaments, skin, the cornea of the eye, and the heart. The D-band of collagen fibrils is an axial periodic density modulation that can be easily characterized by tissue-level X-ray scattering. During mechanical testing, D-band strain is often used as a proxy for fibril strain. However, this approach ignores the coupling between strain and molecular tilt. We examine the validity of this approximation using an elastomeric collagen fibril model that includes both the D-band and a molecular tilt field. In the low strain regime, we show that the D-band strain substantially underestimates fibril strain for strongly twisted collagen fibrils — such as fibrils from skin or corneal tissue.

AB - Collagen fibrils are the main structural component of load-bearing tissues such as tendons, ligaments, skin, the cornea of the eye, and the heart. The D-band of collagen fibrils is an axial periodic density modulation that can be easily characterized by tissue-level X-ray scattering. During mechanical testing, D-band strain is often used as a proxy for fibril strain. However, this approach ignores the coupling between strain and molecular tilt. We examine the validity of this approximation using an elastomeric collagen fibril model that includes both the D-band and a molecular tilt field. In the low strain regime, we show that the D-band strain substantially underestimates fibril strain for strongly twisted collagen fibrils — such as fibrils from skin or corneal tissue.

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JO - Journal of the Mechanical Behavior of Biomedical Materials

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D-band strain underestimates fibril strain for twisted collagen fibrils at low strains

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ASJC Scopus Subject Areas

PubMed: MeSH publication types

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