Depot drug delivery system for 5-fluorouracil after filtration surgery in the rabbit

G. E. Trope, Y. L. Cheng, H. Sheardown, G. S. Liu, I. A. Menon, J. G. Heathcote, D. S. Rootman, W. J. Chiu, L. Gould

Research output: Contribution to journalArticlepeer-review

14 Citations (Scopus)

Abstract

We investigated the potential value of 50:50 poly (DL glycolic acid-lactic acid) (PGLA) copolymer as a degradable depot delivery system for 5-fluorouracil (5-FU) after filtration surgery. Analysis of retrieved discs after implantation in 22 eyes of 22 pigmented rabbits showed a dual drug release profile and polymer mass loss characteristics. In a second group of pigmented rabbits implantation of PGLA discs impregnated with 5-FU (22 eyes) significantly lengthened the survival time of filtration fistulae compared with discs without 5-FU (18 eyes) or no disc (10 eyes) (p < 0.0001). Use of PGLA copolymer impregnated with 5-FU could prove valuable for patients undergoing glaucoma filtering surgery.

Original languageEnglish
Pages (from-to)263-267
Number of pages5
JournalCanadian Journal of Ophthalmology
Volume29
Issue number6
Publication statusPublished - 1994
Externally publishedYes

ASJC Scopus Subject Areas

  • Ophthalmology

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