Depot drug delivery system for 5-fluorouracil after filtration surgery in the rabbit

G. E. Trope; Y. L. Cheng; H. Sheardown; G. S. Liu; I. A. Menon; J. G. Heathcote; D. S. Rootman; W. J. Chiu; L. Gould

Depot drug delivery system for 5-fluorouracil after filtration surgery in the rabbit

G. E. Trope, Y. L. Cheng, H. Sheardown, G. S. Liu, I. A. Menon, J. G. Heathcote, D. S. Rootman, W. J. Chiu, L. Gould

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Résumé

We investigated the potential value of 50:50 poly (DL glycolic acid-lactic acid) (PGLA) copolymer as a degradable depot delivery system for 5-fluorouracil (5-FU) after filtration surgery. Analysis of retrieved discs after implantation in 22 eyes of 22 pigmented rabbits showed a dual drug release profile and polymer mass loss characteristics. In a second group of pigmented rabbits implantation of PGLA discs impregnated with 5-FU (22 eyes) significantly lengthened the survival time of filtration fistulae compared with discs without 5-FU (18 eyes) or no disc (10 eyes) (p < 0.0001). Use of PGLA copolymer impregnated with 5-FU could prove valuable for patients undergoing glaucoma filtering surgery.

Langue d'origine	English
Pages (de-à)	263-267
Nombre de pages	5
Journal	Canadian Journal of Ophthalmology
Volume	29
Numéro de publication	6
Statut de publication	Published - 1994
Publié à l'externe	Oui

ASJC Scopus Subject Areas

Ophthalmology

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title = "Depot drug delivery system for 5-fluorouracil after filtration surgery in the rabbit",

abstract = "We investigated the potential value of 50:50 poly (DL glycolic acid-lactic acid) (PGLA) copolymer as a degradable depot delivery system for 5-fluorouracil (5-FU) after filtration surgery. Analysis of retrieved discs after implantation in 22 eyes of 22 pigmented rabbits showed a dual drug release profile and polymer mass loss characteristics. In a second group of pigmented rabbits implantation of PGLA discs impregnated with 5-FU (22 eyes) significantly lengthened the survival time of filtration fistulae compared with discs without 5-FU (18 eyes) or no disc (10 eyes) (p < 0.0001). Use of PGLA copolymer impregnated with 5-FU could prove valuable for patients undergoing glaucoma filtering surgery.",

author = "Trope, {G. E.} and Cheng, {Y. L.} and H. Sheardown and Liu, {G. S.} and Menon, {I. A.} and Heathcote, {J. G.} and Rootman, {D. S.} and Chiu, {W. J.} and L. Gould",

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language = "English",

volume = "29",

pages = "263--267",

journal = "Canadian Journal of Ophthalmology",

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T1 - Depot drug delivery system for 5-fluorouracil after filtration surgery in the rabbit

AU - Trope, G. E.

AU - Cheng, Y. L.

AU - Sheardown, H.

AU - Liu, G. S.

AU - Menon, I. A.

AU - Heathcote, J. G.

AU - Rootman, D. S.

AU - Chiu, W. J.

AU - Gould, L.

PY - 1994

Y1 - 1994

N2 - We investigated the potential value of 50:50 poly (DL glycolic acid-lactic acid) (PGLA) copolymer as a degradable depot delivery system for 5-fluorouracil (5-FU) after filtration surgery. Analysis of retrieved discs after implantation in 22 eyes of 22 pigmented rabbits showed a dual drug release profile and polymer mass loss characteristics. In a second group of pigmented rabbits implantation of PGLA discs impregnated with 5-FU (22 eyes) significantly lengthened the survival time of filtration fistulae compared with discs without 5-FU (18 eyes) or no disc (10 eyes) (p < 0.0001). Use of PGLA copolymer impregnated with 5-FU could prove valuable for patients undergoing glaucoma filtering surgery.

AB - We investigated the potential value of 50:50 poly (DL glycolic acid-lactic acid) (PGLA) copolymer as a degradable depot delivery system for 5-fluorouracil (5-FU) after filtration surgery. Analysis of retrieved discs after implantation in 22 eyes of 22 pigmented rabbits showed a dual drug release profile and polymer mass loss characteristics. In a second group of pigmented rabbits implantation of PGLA discs impregnated with 5-FU (22 eyes) significantly lengthened the survival time of filtration fistulae compared with discs without 5-FU (18 eyes) or no disc (10 eyes) (p < 0.0001). Use of PGLA copolymer impregnated with 5-FU could prove valuable for patients undergoing glaucoma filtering surgery.

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Depot drug delivery system for 5-fluorouracil after filtration surgery in the rabbit

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