TY - JOUR
T1 - Depression of hepatic cytochrome P-450-dependent monooxygenase systems with administered interferon inducing agents
AU - Renton, Kenneth W.
AU - Mannering, Gilbert J.
PY - 1976/11/22
Y1 - 1976/11/22
N2 - Cytochrome P-450-dependent monooxygenase activities and cytochrome P-450 levels were depressed in hepatic microsomes from rats treated with 12 interferon inducing agents of various types: small molecules (e.g. tilorone), an RNA virus (Mengo), a fungal mycophage (statolon), liver RNA, a synthetic double-stranded polynucleotide (poly rI · poly rC), a bacterial lipopolysaccharide (E. coli endotoxin) and an attenuated bacteria (B. pertussis vaccine). The results suggest that the depression of hepatic cytochrome P-450-dependent monooxygenase systems may be a general property of interferon inducing agents.
AB - Cytochrome P-450-dependent monooxygenase activities and cytochrome P-450 levels were depressed in hepatic microsomes from rats treated with 12 interferon inducing agents of various types: small molecules (e.g. tilorone), an RNA virus (Mengo), a fungal mycophage (statolon), liver RNA, a synthetic double-stranded polynucleotide (poly rI · poly rC), a bacterial lipopolysaccharide (E. coli endotoxin) and an attenuated bacteria (B. pertussis vaccine). The results suggest that the depression of hepatic cytochrome P-450-dependent monooxygenase systems may be a general property of interferon inducing agents.
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U2 - 10.1016/0006-291X(76)90713-0
DO - 10.1016/0006-291X(76)90713-0
M3 - Article
C2 - 187194
AN - SCOPUS:0017192259
SN - 0006-291X
VL - 73
SP - 343
EP - 348
JO - Biochemical and Biophysical Research Communications
JF - Biochemical and Biophysical Research Communications
IS - 2
ER -
