Depression of hepatic cytochrome P-450-dependent monooxygenase systems with administered interferon inducing agents

Kenneth W. Renton; Gilbert J. Mannering

doi:10.1016/0006-291X(76)90713-0

Depression of hepatic cytochrome P-450-dependent monooxygenase systems with administered interferon inducing agents

Kenneth W. Renton, Gilbert J. Mannering

Résultat de recherche: Article › examen par les pairs

170 Citations (Scopus)

Résumé

Cytochrome P-450-dependent monooxygenase activities and cytochrome P-450 levels were depressed in hepatic microsomes from rats treated with 12 interferon inducing agents of various types: small molecules (e.g. tilorone), an RNA virus (Mengo), a fungal mycophage (statolon), liver RNA, a synthetic double-stranded polynucleotide (poly rI · poly rC), a bacterial lipopolysaccharide (E. coli endotoxin) and an attenuated bacteria (B. pertussis vaccine). The results suggest that the depression of hepatic cytochrome P-450-dependent monooxygenase systems may be a general property of interferon inducing agents.

Langue d'origine	English
Pages (de-à)	343-348
Nombre de pages	6
Journal	Biochemical and Biophysical Research Communications
Volume	73
Numéro de publication	2
DOI	https://doi.org/10.1016/0006-291X(76)90713-0
Statut de publication	Published - nov. 22 1976
Publié à l'externe	Oui

ASJC Scopus Subject Areas

Biophysics
Biochemistry
Molecular Biology
Cell Biology

ODD de l’ONU

Cette action contribue à la réalisation des objectifs de développement durable suivants

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10.1016/0006-291X(76)90713-0

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title = "Depression of hepatic cytochrome P-450-dependent monooxygenase systems with administered interferon inducing agents",

abstract = "Cytochrome P-450-dependent monooxygenase activities and cytochrome P-450 levels were depressed in hepatic microsomes from rats treated with 12 interferon inducing agents of various types: small molecules (e.g. tilorone), an RNA virus (Mengo), a fungal mycophage (statolon), liver RNA, a synthetic double-stranded polynucleotide (poly rI · poly rC), a bacterial lipopolysaccharide (E. coli endotoxin) and an attenuated bacteria (B. pertussis vaccine). The results suggest that the depression of hepatic cytochrome P-450-dependent monooxygenase systems may be a general property of interferon inducing agents.",

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AU - Renton, Kenneth W.

AU - Mannering, Gilbert J.

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N2 - Cytochrome P-450-dependent monooxygenase activities and cytochrome P-450 levels were depressed in hepatic microsomes from rats treated with 12 interferon inducing agents of various types: small molecules (e.g. tilorone), an RNA virus (Mengo), a fungal mycophage (statolon), liver RNA, a synthetic double-stranded polynucleotide (poly rI · poly rC), a bacterial lipopolysaccharide (E. coli endotoxin) and an attenuated bacteria (B. pertussis vaccine). The results suggest that the depression of hepatic cytochrome P-450-dependent monooxygenase systems may be a general property of interferon inducing agents.

AB - Cytochrome P-450-dependent monooxygenase activities and cytochrome P-450 levels were depressed in hepatic microsomes from rats treated with 12 interferon inducing agents of various types: small molecules (e.g. tilorone), an RNA virus (Mengo), a fungal mycophage (statolon), liver RNA, a synthetic double-stranded polynucleotide (poly rI · poly rC), a bacterial lipopolysaccharide (E. coli endotoxin) and an attenuated bacteria (B. pertussis vaccine). The results suggest that the depression of hepatic cytochrome P-450-dependent monooxygenase systems may be a general property of interferon inducing agents.

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Depression of hepatic cytochrome P-450-dependent monooxygenase systems with administered interferon inducing agents

Résumé

ASJC Scopus Subject Areas

ODD de l’ONU

Accès au document

Autres fichiers et liens

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