Discovery of immunogenic cell death-inducing ruthenium-based photosensitizers for anticancer photodynamic therapy

Prathyusha Konda; Liubov M. Lifshits; John A. Roque; Houston D. Cole; Colin G. Cameron; Sherri A. McFarland; Shashi Gujar

doi:10.1080/2162402X.2020.1863626

Discovery of immunogenic cell death-inducing ruthenium-based photosensitizers for anticancer photodynamic therapy

Prathyusha Konda, Liubov M. Lifshits, John A. Roque, Houston D. Cole, Colin G. Cameron, Sherri A. McFarland, Shashi Gujar

Medicine

Research output: Contribution to journal › Article › peer-review

26 Citations (Scopus)

Abstract

We report a new class of ruthenium (Ru)-based photosensitizers that induce potent cytotoxicity in melanoma cells following activation with NIR light. In addition to the direct cytotoxic effect, this Ru-based photodynamic therapy induces immunogenic cell death in melanoma cells that can be therapeutically exploited to establish protective antitumor immunity.

Original language	English
Article number	1863626
Journal	OncoImmunology
Volume	10
Issue number	1
DOIs	https://doi.org/10.1080/2162402X.2020.1863626
Publication status	Published - 2021

Bibliographical note

Funding Information:
This work was supported via the National Cancer Institute (NCI) of the National Institutes of Health (NIH)’s Award R01CA222227 to S.A.M. and S.G. The content in this article is solely the responsibility of the authors and does not necessarily represent the official views of the NIH.

Publisher Copyright:
© 2020 The Author(s). Published with license by Taylor & Francis Group, LLC.

ASJC Scopus Subject Areas

Immunology and Allergy
Immunology
Oncology

PubMed: MeSH publication types

Journal Article
Research Support, N.I.H., Extramural

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10.1080/2162402X.2020.1863626

Cite this

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abstract = "We report a new class of ruthenium (Ru)-based photosensitizers that induce potent cytotoxicity in melanoma cells following activation with NIR light. In addition to the direct cytotoxic effect, this Ru-based photodynamic therapy induces immunogenic cell death in melanoma cells that can be therapeutically exploited to establish protective antitumor immunity.",

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AU - Konda, Prathyusha

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AU - Roque, John A.

AU - Cole, Houston D.

AU - Cameron, Colin G.

AU - McFarland, Sherri A.

AU - Gujar, Shashi

N1 - Funding Information: This work was supported via the National Cancer Institute (NCI) of the National Institutes of Health (NIH)’s Award R01CA222227 to S.A.M. and S.G. The content in this article is solely the responsibility of the authors and does not necessarily represent the official views of the NIH. Publisher Copyright: © 2020 The Author(s). Published with license by Taylor & Francis Group, LLC.

PY - 2021

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N2 - We report a new class of ruthenium (Ru)-based photosensitizers that induce potent cytotoxicity in melanoma cells following activation with NIR light. In addition to the direct cytotoxic effect, this Ru-based photodynamic therapy induces immunogenic cell death in melanoma cells that can be therapeutically exploited to establish protective antitumor immunity.

AB - We report a new class of ruthenium (Ru)-based photosensitizers that induce potent cytotoxicity in melanoma cells following activation with NIR light. In addition to the direct cytotoxic effect, this Ru-based photodynamic therapy induces immunogenic cell death in melanoma cells that can be therapeutically exploited to establish protective antitumor immunity.

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Discovery of immunogenic cell death-inducing ruthenium-based photosensitizers for anticancer photodynamic therapy

Abstract

Bibliographical note

ASJC Scopus Subject Areas

PubMed: MeSH publication types

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