Discovery of immunogenic cell death-inducing ruthenium-based photosensitizers for anticancer photodynamic therapy

Prathyusha Konda; Liubov M. Lifshits; John A. Roque; Houston D. Cole; Colin G. Cameron; Sherri A. McFarland; Shashi Gujar

doi:10.1080/2162402X.2020.1863626

Discovery of immunogenic cell death-inducing ruthenium-based photosensitizers for anticancer photodynamic therapy

Prathyusha Konda, Liubov M. Lifshits, John A. Roque, Houston D. Cole, Colin G. Cameron, Sherri A. McFarland, Shashi Gujar

Medicine

Résultat de recherche: Article › examen par les pairs

26 Citations (Scopus)

Résumé

We report a new class of ruthenium (Ru)-based photosensitizers that induce potent cytotoxicity in melanoma cells following activation with NIR light. In addition to the direct cytotoxic effect, this Ru-based photodynamic therapy induces immunogenic cell death in melanoma cells that can be therapeutically exploited to establish protective antitumor immunity.

Langue d'origine	English
Numéro d'article	1863626
Journal	OncoImmunology
Volume	10
Numéro de publication	1
DOI	https://doi.org/10.1080/2162402X.2020.1863626
Statut de publication	Published - 2021

Note bibliographique

Funding Information:
This work was supported via the National Cancer Institute (NCI) of the National Institutes of Health (NIH)’s Award R01CA222227 to S.A.M. and S.G. The content in this article is solely the responsibility of the authors and does not necessarily represent the official views of the NIH.

Publisher Copyright:
© 2020 The Author(s). Published with license by Taylor & Francis Group, LLC.

ASJC Scopus Subject Areas

Immunology and Allergy
Immunology
Oncology

PubMed: MeSH publication types

Journal Article
Research Support, N.I.H., Extramural

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10.1080/2162402X.2020.1863626

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abstract = "We report a new class of ruthenium (Ru)-based photosensitizers that induce potent cytotoxicity in melanoma cells following activation with NIR light. In addition to the direct cytotoxic effect, this Ru-based photodynamic therapy induces immunogenic cell death in melanoma cells that can be therapeutically exploited to establish protective antitumor immunity.",

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AU - Roque, John A.

AU - Cole, Houston D.

AU - Cameron, Colin G.

AU - McFarland, Sherri A.

AU - Gujar, Shashi

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PY - 2021

Y1 - 2021

N2 - We report a new class of ruthenium (Ru)-based photosensitizers that induce potent cytotoxicity in melanoma cells following activation with NIR light. In addition to the direct cytotoxic effect, this Ru-based photodynamic therapy induces immunogenic cell death in melanoma cells that can be therapeutically exploited to establish protective antitumor immunity.

AB - We report a new class of ruthenium (Ru)-based photosensitizers that induce potent cytotoxicity in melanoma cells following activation with NIR light. In addition to the direct cytotoxic effect, this Ru-based photodynamic therapy induces immunogenic cell death in melanoma cells that can be therapeutically exploited to establish protective antitumor immunity.

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Discovery of immunogenic cell death-inducing ruthenium-based photosensitizers for anticancer photodynamic therapy

Résumé

Note bibliographique

ASJC Scopus Subject Areas

PubMed: MeSH publication types

Accès au document

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