Distinct subsets of human Vα24-invariant NKT cells: Cytokine responses and chemokine receptor expression

Chang H. Kim; Eugene C. Butcher; Brent Johnston

doi:10.1016/S1471-4906(02)02323-2

Distinct subsets of human Vα24-invariant NKT cells: Cytokine responses and chemokine receptor expression

Chang H. Kim, Eugene C. Butcher, Brent Johnston

Research output: Contribution to journal › Review article › peer-review

99 Citations (Scopus)

Abstract

CD1d-restricted T-cell receptor Vα-invariant natural killer T (NKT) cells are important regulators of immune responses through their efficient secretion of T helper 1 (Th1) and Th2 cytokines. Recently, it has been shown that this NKT-cell population contains functionally distinct subsets, producing different sets of cytokines and cytotoxic effector molecules. NKT-cell subsets are also distinct from each other in their expression of adhesion molecules and chemokine receptors, suggesting that they might be targeted to different tissues and perform different immune functions.

Original language	English
Pages (from-to)	516-519
Number of pages	4
Journal	Trends in Immunology
Volume	23
Issue number	11
DOIs	https://doi.org/10.1016/S1471-4906(02)02323-2
Publication status	Published - Nov 1 2002
Externally published	Yes

Bibliographical note

Funding Information:
C.H.K. is a special fellow of the Leukemia and Lymphoma Society. B.J. is the recipient of a Canadian Institutes of Health Research fellowship.

ASJC Scopus Subject Areas

Immunology and Allergy
Immunology

PubMed: MeSH publication types

News
Research Support, Non-U.S. Gov't

Access to Document

10.1016/S1471-4906(02)02323-2

Cite this

@article{0735a987166646a08446a3a4cf8d14c8,

title = "Distinct subsets of human Vα24-invariant NKT cells: Cytokine responses and chemokine receptor expression",

abstract = "CD1d-restricted T-cell receptor Vα-invariant natural killer T (NKT) cells are important regulators of immune responses through their efficient secretion of T helper 1 (Th1) and Th2 cytokines. Recently, it has been shown that this NKT-cell population contains functionally distinct subsets, producing different sets of cytokines and cytotoxic effector molecules. NKT-cell subsets are also distinct from each other in their expression of adhesion molecules and chemokine receptors, suggesting that they might be targeted to different tissues and perform different immune functions.",

author = "Kim, {Chang H.} and Butcher, {Eugene C.} and Brent Johnston",

note = "Funding Information: C.H.K. is a special fellow of the Leukemia and Lymphoma Society. B.J. is the recipient of a Canadian Institutes of Health Research fellowship.",

year = "2002",

month = nov,

day = "1",

doi = "10.1016/S1471-4906(02)02323-2",

language = "English",

volume = "23",

pages = "516--519",

journal = "Trends in Immunology",

issn = "1471-4906",

publisher = "Elsevier Limited",

number = "11",

}

TY - JOUR

T1 - Distinct subsets of human Vα24-invariant NKT cells

T2 - Cytokine responses and chemokine receptor expression

AU - Kim, Chang H.

AU - Butcher, Eugene C.

AU - Johnston, Brent

N1 - Funding Information: C.H.K. is a special fellow of the Leukemia and Lymphoma Society. B.J. is the recipient of a Canadian Institutes of Health Research fellowship.

PY - 2002/11/1

Y1 - 2002/11/1

N2 - CD1d-restricted T-cell receptor Vα-invariant natural killer T (NKT) cells are important regulators of immune responses through their efficient secretion of T helper 1 (Th1) and Th2 cytokines. Recently, it has been shown that this NKT-cell population contains functionally distinct subsets, producing different sets of cytokines and cytotoxic effector molecules. NKT-cell subsets are also distinct from each other in their expression of adhesion molecules and chemokine receptors, suggesting that they might be targeted to different tissues and perform different immune functions.

AB - CD1d-restricted T-cell receptor Vα-invariant natural killer T (NKT) cells are important regulators of immune responses through their efficient secretion of T helper 1 (Th1) and Th2 cytokines. Recently, it has been shown that this NKT-cell population contains functionally distinct subsets, producing different sets of cytokines and cytotoxic effector molecules. NKT-cell subsets are also distinct from each other in their expression of adhesion molecules and chemokine receptors, suggesting that they might be targeted to different tissues and perform different immune functions.

UR - http://www.scopus.com/inward/record.url?scp=0036838607&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0036838607&partnerID=8YFLogxK

U2 - 10.1016/S1471-4906(02)02323-2

DO - 10.1016/S1471-4906(02)02323-2

M3 - Review article

C2 - 12401396

AN - SCOPUS:0036838607

SN - 1471-4906

VL - 23

SP - 516

EP - 519

JO - Trends in Immunology

JF - Trends in Immunology

IS - 11

ER -

Distinct subsets of human Vα24-invariant NKT cells: Cytokine responses and chemokine receptor expression

Abstract

Bibliographical note

ASJC Scopus Subject Areas

PubMed: MeSH publication types

Access to Document

Other files and links

Fingerprint

Cite this