Distinct subsets of human Vα24-invariant NKT cells: Cytokine responses and chemokine receptor expression

Chang H. Kim; Eugene C. Butcher; Brent Johnston

doi:10.1016/S1471-4906(02)02323-2

Distinct subsets of human Vα24-invariant NKT cells: Cytokine responses and chemokine receptor expression

Chang H. Kim, Eugene C. Butcher, Brent Johnston

Résultat de recherche: Review article › examen par les pairs

99 Citations (Scopus)

Résumé

CD1d-restricted T-cell receptor Vα-invariant natural killer T (NKT) cells are important regulators of immune responses through their efficient secretion of T helper 1 (Th1) and Th2 cytokines. Recently, it has been shown that this NKT-cell population contains functionally distinct subsets, producing different sets of cytokines and cytotoxic effector molecules. NKT-cell subsets are also distinct from each other in their expression of adhesion molecules and chemokine receptors, suggesting that they might be targeted to different tissues and perform different immune functions.

Langue d'origine	English
Pages (de-à)	516-519
Nombre de pages	4
Journal	Trends in Immunology
Volume	23
Numéro de publication	11
DOI	https://doi.org/10.1016/S1471-4906(02)02323-2
Statut de publication	Published - nov. 1 2002
Publié à l'externe	Oui

Note bibliographique

Funding Information:
C.H.K. is a special fellow of the Leukemia and Lymphoma Society. B.J. is the recipient of a Canadian Institutes of Health Research fellowship.

ASJC Scopus Subject Areas

Immunology and Allergy
Immunology

PubMed: MeSH publication types

News
Research Support, Non-U.S. Gov't

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10.1016/S1471-4906(02)02323-2

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abstract = "CD1d-restricted T-cell receptor Vα-invariant natural killer T (NKT) cells are important regulators of immune responses through their efficient secretion of T helper 1 (Th1) and Th2 cytokines. Recently, it has been shown that this NKT-cell population contains functionally distinct subsets, producing different sets of cytokines and cytotoxic effector molecules. NKT-cell subsets are also distinct from each other in their expression of adhesion molecules and chemokine receptors, suggesting that they might be targeted to different tissues and perform different immune functions.",

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AU - Butcher, Eugene C.

AU - Johnston, Brent

N1 - Funding Information: C.H.K. is a special fellow of the Leukemia and Lymphoma Society. B.J. is the recipient of a Canadian Institutes of Health Research fellowship.

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N2 - CD1d-restricted T-cell receptor Vα-invariant natural killer T (NKT) cells are important regulators of immune responses through their efficient secretion of T helper 1 (Th1) and Th2 cytokines. Recently, it has been shown that this NKT-cell population contains functionally distinct subsets, producing different sets of cytokines and cytotoxic effector molecules. NKT-cell subsets are also distinct from each other in their expression of adhesion molecules and chemokine receptors, suggesting that they might be targeted to different tissues and perform different immune functions.

AB - CD1d-restricted T-cell receptor Vα-invariant natural killer T (NKT) cells are important regulators of immune responses through their efficient secretion of T helper 1 (Th1) and Th2 cytokines. Recently, it has been shown that this NKT-cell population contains functionally distinct subsets, producing different sets of cytokines and cytotoxic effector molecules. NKT-cell subsets are also distinct from each other in their expression of adhesion molecules and chemokine receptors, suggesting that they might be targeted to different tissues and perform different immune functions.

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Distinct subsets of human Vα24-invariant NKT cells: Cytokine responses and chemokine receptor expression

Résumé

Note bibliographique

ASJC Scopus Subject Areas

PubMed: MeSH publication types

Accès au document

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