Dopaminergic neurons in the nucleus raphe dorsalis innervate the prefrontal cortex in the rat: a combined retrograde tracing and immunohistochemical study using anti-dopamine serum

M. Yoshida; M. Shirouzu; M. Tanaka; K. Semba; H. C. Fibiger

doi:10.1016/0006-8993(89)91091-3

Dopaminergic neurons in the nucleus raphe dorsalis innervate the prefrontal cortex in the rat: a combined retrograde tracing and immunohistochemical study using anti-dopamine serum

M. Yoshida, M. Shirouzu, M. Tanaka, K. Semba, H. C. Fibiger

Research output: Contribution to journal › Article › peer-review

56 Citations (Scopus)

Abstract

The existence of a dopaminergic projection from the nucleus raphe dorsalis (RD) to the prefrontal cortex of the rat was demonstrated by combining immunohistochemistry with retrograde tracing. Injection of horseradish peroxidase or Fluoro-gold into the medial prefrontal cortex resulted in the appearance of retrogradely labelled neurons in the RD and in other brain regions. Some of these retrogradely labelled RD neurons were shown to be immunoreactive for dopamine. These data support the view that these dopaminergic RD neurons represent an extension of the A10 cell group.

Original language	English
Pages (from-to)	373-376
Number of pages	4
Journal	Brain Research
Volume	496
Issue number	1-2
DOIs	https://doi.org/10.1016/0006-8993(89)91091-3
Publication status	Published - Sept 4 1989
Externally published	Yes

Bibliographical note

Funding Information:
We thank C.-S. Tham for her excellentte chnical assistanceS. upportedin part by the Medical Re-searchC ouncilof Canada( PG-23).

ASJC Scopus Subject Areas

General Neuroscience
Molecular Biology
Clinical Neurology
Developmental Biology

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10.1016/0006-8993(89)91091-3

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abstract = "The existence of a dopaminergic projection from the nucleus raphe dorsalis (RD) to the prefrontal cortex of the rat was demonstrated by combining immunohistochemistry with retrograde tracing. Injection of horseradish peroxidase or Fluoro-gold into the medial prefrontal cortex resulted in the appearance of retrogradely labelled neurons in the RD and in other brain regions. Some of these retrogradely labelled RD neurons were shown to be immunoreactive for dopamine. These data support the view that these dopaminergic RD neurons represent an extension of the A10 cell group.",

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T2 - a combined retrograde tracing and immunohistochemical study using anti-dopamine serum

AU - Yoshida, M.

AU - Shirouzu, M.

AU - Tanaka, M.

AU - Semba, K.

AU - Fibiger, H. C.

N1 - Funding Information: We thank C.-S. Tham for her excellentte chnical assistanceS. upportedin part by the Medical Re-searchC ouncilof Canada( PG-23).

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AB - The existence of a dopaminergic projection from the nucleus raphe dorsalis (RD) to the prefrontal cortex of the rat was demonstrated by combining immunohistochemistry with retrograde tracing. Injection of horseradish peroxidase or Fluoro-gold into the medial prefrontal cortex resulted in the appearance of retrogradely labelled neurons in the RD and in other brain regions. Some of these retrogradely labelled RD neurons were shown to be immunoreactive for dopamine. These data support the view that these dopaminergic RD neurons represent an extension of the A10 cell group.

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Dopaminergic neurons in the nucleus raphe dorsalis innervate the prefrontal cortex in the rat: a combined retrograde tracing and immunohistochemical study using anti-dopamine serum

Abstract

Bibliographical note

ASJC Scopus Subject Areas

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