Dopaminergic neurons in the nucleus raphe dorsalis innervate the prefrontal cortex in the rat: a combined retrograde tracing and immunohistochemical study using anti-dopamine serum

M. Yoshida; M. Shirouzu; M. Tanaka; K. Semba; H. C. Fibiger

doi:10.1016/0006-8993(89)91091-3

Dopaminergic neurons in the nucleus raphe dorsalis innervate the prefrontal cortex in the rat: a combined retrograde tracing and immunohistochemical study using anti-dopamine serum

M. Yoshida, M. Shirouzu, M. Tanaka, K. Semba, H. C. Fibiger

Résultat de recherche: Article › examen par les pairs

56 Citations (Scopus)

Résumé

The existence of a dopaminergic projection from the nucleus raphe dorsalis (RD) to the prefrontal cortex of the rat was demonstrated by combining immunohistochemistry with retrograde tracing. Injection of horseradish peroxidase or Fluoro-gold into the medial prefrontal cortex resulted in the appearance of retrogradely labelled neurons in the RD and in other brain regions. Some of these retrogradely labelled RD neurons were shown to be immunoreactive for dopamine. These data support the view that these dopaminergic RD neurons represent an extension of the A10 cell group.

Langue d'origine	English
Pages (de-à)	373-376
Nombre de pages	4
Journal	Brain Research
Volume	496
Numéro de publication	1-2
DOI	https://doi.org/10.1016/0006-8993(89)91091-3
Statut de publication	Published - sept. 4 1989
Publié à l'externe	Oui

Note bibliographique

Funding Information:
We thank C.-S. Tham for her excellentte chnical assistanceS. upportedin part by the Medical Re-searchC ouncilof Canada( PG-23).

ASJC Scopus Subject Areas

General Neuroscience
Molecular Biology
Clinical Neurology
Developmental Biology

Accès au document

10.1016/0006-8993(89)91091-3

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abstract = "The existence of a dopaminergic projection from the nucleus raphe dorsalis (RD) to the prefrontal cortex of the rat was demonstrated by combining immunohistochemistry with retrograde tracing. Injection of horseradish peroxidase or Fluoro-gold into the medial prefrontal cortex resulted in the appearance of retrogradely labelled neurons in the RD and in other brain regions. Some of these retrogradely labelled RD neurons were shown to be immunoreactive for dopamine. These data support the view that these dopaminergic RD neurons represent an extension of the A10 cell group.",

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AU - Semba, K.

AU - Fibiger, H. C.

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