Effects of perhexiline maleate on coronary flow distribution in the ischemic canine myocardium

G. A. Klassen; F. Sestier; A. L'Abbate; R. R. Mildenberger; D. T. Zborowska-Sluis

doi:10.1161/01.CIR.54.1.14

Effects of perhexiline maleate on coronary flow distribution in the ischemic canine myocardium

G. A. Klassen, F. Sestier, A. L'Abbate, R. R. Mildenberger, D. T. Zborowska-Sluis

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Abstract

Intravenous perhexilline maleate in a canine preparation with fixed coronary flow increases coronary diastolic pressure. It also redistributed coronary flow so as to preserve endocardial flow. Myocardial oxygen consumption was reduced and lactate uptake enhanced by the drug. It had no effect upon the threshold for ischemic induced left ventricular failure.

Original language	English
Pages (from-to)	14-20
Number of pages	7
Journal	Unknown Journal
Volume	54
Issue number	1
DOIs	https://doi.org/10.1161/01.CIR.54.1.14
Publication status	Published - 1976
Externally published	Yes

ASJC Scopus Subject Areas

Cardiology and Cardiovascular Medicine
Physiology (medical)

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10.1161/01.CIR.54.1.14

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title = "Effects of perhexiline maleate on coronary flow distribution in the ischemic canine myocardium",

abstract = "Intravenous perhexilline maleate in a canine preparation with fixed coronary flow increases coronary diastolic pressure. It also redistributed coronary flow so as to preserve endocardial flow. Myocardial oxygen consumption was reduced and lactate uptake enhanced by the drug. It had no effect upon the threshold for ischemic induced left ventricular failure.",

author = "Klassen, {G. A.} and F. Sestier and A. L'Abbate and Mildenberger, {R. R.} and Zborowska-Sluis, {D. T.}",

year = "1976",

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AU - Klassen, G. A.

AU - Sestier, F.

AU - L'Abbate, A.

AU - Mildenberger, R. R.

AU - Zborowska-Sluis, D. T.

PY - 1976

Y1 - 1976

N2 - Intravenous perhexilline maleate in a canine preparation with fixed coronary flow increases coronary diastolic pressure. It also redistributed coronary flow so as to preserve endocardial flow. Myocardial oxygen consumption was reduced and lactate uptake enhanced by the drug. It had no effect upon the threshold for ischemic induced left ventricular failure.

AB - Intravenous perhexilline maleate in a canine preparation with fixed coronary flow increases coronary diastolic pressure. It also redistributed coronary flow so as to preserve endocardial flow. Myocardial oxygen consumption was reduced and lactate uptake enhanced by the drug. It had no effect upon the threshold for ischemic induced left ventricular failure.

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DO - 10.1161/01.CIR.54.1.14

M3 - Article

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SP - 14

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JO - Unknown Journal

JF - Unknown Journal

IS - 1

ER -

Effects of perhexiline maleate on coronary flow distribution in the ischemic canine myocardium

Abstract

ASJC Scopus Subject Areas

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