Effects of perhexiline maleate on coronary flow distribution in the ischemic canine myocardium

G. A. Klassen, F. Sestier, A. L'Abbate, R. R. Mildenberger, D. T. Zborowska-Sluis

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)

Abstract

Intravenous perhexilline maleate in a canine preparation with fixed coronary flow increases coronary diastolic pressure. It also redistributed coronary flow so as to preserve endocardial flow. Myocardial oxygen consumption was reduced and lactate uptake enhanced by the drug. It had no effect upon the threshold for ischemic induced left ventricular failure.

Original languageEnglish
Pages (from-to)14-20
Number of pages7
JournalUnknown Journal
Volume54
Issue number1
DOIs
Publication statusPublished - 1976
Externally publishedYes

ASJC Scopus Subject Areas

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

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