Evidence of carbonic anhydrase activity in skeletal muscle: A role for facilitative carbon dioxide transport

Danuta T. Zborowska-Sluis; Antonio L'Abbate; Gerald A. Klassen

doi:10.1016/0034-5687(74)90064-4

Evidence of carbonic anhydrase activity in skeletal muscle: A role for facilitative carbon dioxide transport

Danuta T. Zborowska-Sluis, Antonio L'Abbate, Gerald A. Klassen

Research output: Contribution to journal › Article › peer-review

21 Citations (Scopus)

Abstract

Carbon dioxide, water and vascular space were measured in the hind limb of the dog, with blood and plasma perfusion, before and after the administration of acetazolamide. Inhibition of carbonic anhydrase by acetazolamide resulted in a decrease in carbon dioxide space from greater than water space to similar to vascular space. This observation is consistent with the presence of carbonic anhydrase in the extravascular compartment. Its presence in this location could act to facilitate carbon dioxide transport.

Original language	English
Pages (from-to)	341-350
Number of pages	10
Journal	Respiration Physiology
Volume	21
Issue number	3
DOIs	https://doi.org/10.1016/0034-5687(74)90064-4
Publication status	Published - Sept 1974
Externally published	Yes

Bibliographical note

Funding Information:
1 Supported by grants from the Medical Research Council and the Joseph Edwards ’ Supported by a grant from the Consiglio Nazionale delle Ricerche, Rome, Italy.

ASJC Scopus Subject Areas

Physiology
Pulmonary and Respiratory Medicine

Access to Document

10.1016/0034-5687(74)90064-4

Cite this

@article{f625b79315d0474ba99bf56bd95019d6,

title = "Evidence of carbonic anhydrase activity in skeletal muscle: A role for facilitative carbon dioxide transport",

abstract = "Carbon dioxide, water and vascular space were measured in the hind limb of the dog, with blood and plasma perfusion, before and after the administration of acetazolamide. Inhibition of carbonic anhydrase by acetazolamide resulted in a decrease in carbon dioxide space from greater than water space to similar to vascular space. This observation is consistent with the presence of carbonic anhydrase in the extravascular compartment. Its presence in this location could act to facilitate carbon dioxide transport.",

author = "Zborowska-Sluis, {Danuta T.} and Antonio L'Abbate and Klassen, {Gerald A.}",

note = "Funding Information: 1 Supported by grants from the Medical Research Council and the Joseph Edwards {\textquoteright} Supported by a grant from the Consiglio Nazionale delle Ricerche, Rome, Italy.",

year = "1974",

month = sep,

doi = "10.1016/0034-5687(74)90064-4",

language = "English",

volume = "21",

pages = "341--350",

journal = "Respiration Physiology",

issn = "0034-5687",

publisher = "Elsevier",

number = "3",

}

TY - JOUR

T1 - Evidence of carbonic anhydrase activity in skeletal muscle

T2 - A role for facilitative carbon dioxide transport

AU - Zborowska-Sluis, Danuta T.

AU - L'Abbate, Antonio

AU - Klassen, Gerald A.

N1 - Funding Information: 1 Supported by grants from the Medical Research Council and the Joseph Edwards ’ Supported by a grant from the Consiglio Nazionale delle Ricerche, Rome, Italy.

PY - 1974/9

Y1 - 1974/9

N2 - Carbon dioxide, water and vascular space were measured in the hind limb of the dog, with blood and plasma perfusion, before and after the administration of acetazolamide. Inhibition of carbonic anhydrase by acetazolamide resulted in a decrease in carbon dioxide space from greater than water space to similar to vascular space. This observation is consistent with the presence of carbonic anhydrase in the extravascular compartment. Its presence in this location could act to facilitate carbon dioxide transport.

AB - Carbon dioxide, water and vascular space were measured in the hind limb of the dog, with blood and plasma perfusion, before and after the administration of acetazolamide. Inhibition of carbonic anhydrase by acetazolamide resulted in a decrease in carbon dioxide space from greater than water space to similar to vascular space. This observation is consistent with the presence of carbonic anhydrase in the extravascular compartment. Its presence in this location could act to facilitate carbon dioxide transport.

UR - http://www.scopus.com/inward/record.url?scp=0016287672&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0016287672&partnerID=8YFLogxK

U2 - 10.1016/0034-5687(74)90064-4

DO - 10.1016/0034-5687(74)90064-4

M3 - Article

C2 - 4213833

AN - SCOPUS:0016287672

SN - 0034-5687

VL - 21

SP - 341

EP - 350

JO - Respiration Physiology

JF - Respiration Physiology

IS - 3

ER -

Evidence of carbonic anhydrase activity in skeletal muscle: A role for facilitative carbon dioxide transport

Abstract

Bibliographical note

ASJC Scopus Subject Areas

Access to Document

Other files and links

Fingerprint

Cite this