Genetic variation at the synaptic vesicle gene SV2A is associated with schizophrenia

Manuel Mattheisen, Thomas W. Mühleisen, Jana Strohmaier, Jens Treutlein, Igor Nenadic, Margrieta Alblas, Sandra Meier, Franziska Degenhardt, Stefan Herms, Per Hoffmann, Stephanie H. Witt, Ina Giegling, Heinrich Sauer, Thomas G. Schulze, Dan Rujescu, Markus M. Nöthen, Marcella Rietschel, Sven Cichon

Research output: Contribution to journalArticlepeer-review

13 Citations (Scopus)

Abstract

Convergent evidence from pharmacological and animal studies suggests a possible role for the synaptic vesicle glycoprotein 2A gene (. SV2A) in schizophrenia susceptibility. To test systematically all common variants in the SV2A gene region for an association with schizophrenia, we used a HapMap-based haplotype tagging approach and tested five SNPs in 794 patients and 843 controls. The SNP rs15931 showed evidence for an association with schizophrenia and was followed-up in an independent sample of 2581 individuals (overall p-value. =. 0.0042, OR. =. 0.779). Our study in the German population provides evidence, at a genetic level, for the involvement of the SV2A gene region in schizophrenia.

Original languageEnglish
Pages (from-to)262-265
Number of pages4
JournalSchizophrenia Research
Volume141
Issue number2-3
DOIs
Publication statusPublished - Nov 2012
Externally publishedYes

Bibliographical note

Funding Information:
This study was supported by the German Federal Ministry of Education and Research (BMBF), within the context of the German National Genome Research Network plus (NGFNplus) , and the Integrated Genome Research Network (IG) MooDS (grant 01GS08144 to Sven Cichon and Markus M. Nöthen, grant 01GS08147 to Marcella Rietschel). This work was supported by grants U01 HL089856 , R01 MH087590 and R01 MH081862 . Igor Nenadic was supported by a Junior Scientist Grant of the IZKF, Medical School, Jena University Hospital . Igor Nenadic, Heinrich Sauer, Markus M. Nöthen, and Sven Cichon were additionally supported through an EU grant (EUTwinsS network, RTN, FP6). Jana Strohmaier was supported by the German Research Foundation ( GRK 793 ).

ASJC Scopus Subject Areas

  • Psychiatry and Mental health
  • Biological Psychiatry

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