Genetic variation at the synaptic vesicle gene SV2A is associated with schizophrenia

Manuel Mattheisen; Thomas W. Mühleisen; Jana Strohmaier; Jens Treutlein; Igor Nenadic; Margrieta Alblas; Sandra Meier; Franziska Degenhardt; Stefan Herms; Per Hoffmann; Stephanie H. Witt; Ina Giegling; Heinrich Sauer; Thomas G. Schulze; Dan Rujescu; Markus M. Nöthen; Marcella Rietschel; Sven Cichon

doi:10.1016/j.schres.2012.08.027

Genetic variation at the synaptic vesicle gene SV2A is associated with schizophrenia

Manuel Mattheisen, Thomas W. Mühleisen, Jana Strohmaier, Jens Treutlein, Igor Nenadic, Margrieta Alblas, Sandra Meier, Franziska Degenhardt, Stefan Herms, Per Hoffmann, Stephanie H. Witt, Ina Giegling, Heinrich Sauer, Thomas G. Schulze, Dan Rujescu, Markus M. Nöthen, Marcella Rietschel, Sven Cichon

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13 Citas (Scopus)

Resumen

Convergent evidence from pharmacological and animal studies suggests a possible role for the synaptic vesicle glycoprotein 2A gene (. SV2A) in schizophrenia susceptibility. To test systematically all common variants in the SV2A gene region for an association with schizophrenia, we used a HapMap-based haplotype tagging approach and tested five SNPs in 794 patients and 843 controls. The SNP rs15931 showed evidence for an association with schizophrenia and was followed-up in an independent sample of 2581 individuals (overall p-value. =. 0.0042, OR. =. 0.779). Our study in the German population provides evidence, at a genetic level, for the involvement of the SV2A gene region in schizophrenia.

Idioma original	English
Páginas (desde-hasta)	262-265
Número de páginas	4
Publicación	Schizophrenia Research
Volumen	141
N.º	2-3
DOI	https://doi.org/10.1016/j.schres.2012.08.027
Estado	Published - nov. 2012
Publicado de forma externa	Sí

Nota bibliográfica

Funding Information:
This study was supported by the German Federal Ministry of Education and Research (BMBF), within the context of the German National Genome Research Network plus (NGFNplus) , and the Integrated Genome Research Network (IG) MooDS (grant 01GS08144 to Sven Cichon and Markus M. Nöthen, grant 01GS08147 to Marcella Rietschel). This work was supported by grants U01 HL089856 , R01 MH087590 and R01 MH081862 . Igor Nenadic was supported by a Junior Scientist Grant of the IZKF, Medical School, Jena University Hospital . Igor Nenadic, Heinrich Sauer, Markus M. Nöthen, and Sven Cichon were additionally supported through an EU grant (EUTwinsS network, RTN, FP6). Jana Strohmaier was supported by the German Research Foundation ( GRK 793 ).

ASJC Scopus Subject Areas

Psychiatry and Mental health
Biological Psychiatry

ODS de las Naciones Unidas

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Mattheisen, M., Mühleisen, T. W., Strohmaier, J., Treutlein, J., Nenadic, I., Alblas, M., Meier, S., Degenhardt, F., Herms, S., Hoffmann, P., Witt, S. H., Giegling, I., Sauer, H., Schulze, T. G., Rujescu, D., Nöthen, M. M., Rietschel, M., & Cichon, S. (2012). Genetic variation at the synaptic vesicle gene SV2A is associated with schizophrenia. Schizophrenia Research, 141(2-3), 262-265. https://doi.org/10.1016/j.schres.2012.08.027

Mattheisen, M, Mühleisen, TW, Strohmaier, J, Treutlein, J, Nenadic, I, Alblas, M, Meier, S, Degenhardt, F, Herms, S, Hoffmann, P, Witt, SH, Giegling, I, Sauer, H, Schulze, TG, Rujescu, D, Nöthen, MM, Rietschel, M & Cichon, S 2012, 'Genetic variation at the synaptic vesicle gene SV2A is associated with schizophrenia', Schizophrenia Research, vol. 141, n.º 2-3, pp. 262-265. https://doi.org/10.1016/j.schres.2012.08.027

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title = "Genetic variation at the synaptic vesicle gene SV2A is associated with schizophrenia",

abstract = "Convergent evidence from pharmacological and animal studies suggests a possible role for the synaptic vesicle glycoprotein 2A gene (. SV2A) in schizophrenia susceptibility. To test systematically all common variants in the SV2A gene region for an association with schizophrenia, we used a HapMap-based haplotype tagging approach and tested five SNPs in 794 patients and 843 controls. The SNP rs15931 showed evidence for an association with schizophrenia and was followed-up in an independent sample of 2581 individuals (overall p-value. =. 0.0042, OR. =. 0.779). Our study in the German population provides evidence, at a genetic level, for the involvement of the SV2A gene region in schizophrenia.",

author = "Manuel Mattheisen and M{\"u}hleisen, {Thomas W.} and Jana Strohmaier and Jens Treutlein and Igor Nenadic and Margrieta Alblas and Sandra Meier and Franziska Degenhardt and Stefan Herms and Per Hoffmann and Witt, {Stephanie H.} and Ina Giegling and Heinrich Sauer and Schulze, {Thomas G.} and Dan Rujescu and N{\"o}then, {Markus M.} and Marcella Rietschel and Sven Cichon",

note = "Funding Information: This study was supported by the German Federal Ministry of Education and Research (BMBF), within the context of the German National Genome Research Network plus (NGFNplus) , and the Integrated Genome Research Network (IG) MooDS (grant 01GS08144 to Sven Cichon and Markus M. N{\"o}then, grant 01GS08147 to Marcella Rietschel). This work was supported by grants U01 HL089856 , R01 MH087590 and R01 MH081862 . Igor Nenadic was supported by a Junior Scientist Grant of the IZKF, Medical School, Jena University Hospital . Igor Nenadic, Heinrich Sauer, Markus M. N{\"o}then, and Sven Cichon were additionally supported through an EU grant (EUTwinsS network, RTN, FP6). Jana Strohmaier was supported by the German Research Foundation ( GRK 793 ). ",

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doi = "10.1016/j.schres.2012.08.027",

language = "English",

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AU - Mattheisen, Manuel

AU - Mühleisen, Thomas W.

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AU - Alblas, Margrieta

AU - Meier, Sandra

AU - Degenhardt, Franziska

AU - Herms, Stefan

AU - Hoffmann, Per

AU - Witt, Stephanie H.

AU - Giegling, Ina

AU - Sauer, Heinrich

AU - Schulze, Thomas G.

AU - Rujescu, Dan

AU - Nöthen, Markus M.

AU - Rietschel, Marcella

AU - Cichon, Sven

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N2 - Convergent evidence from pharmacological and animal studies suggests a possible role for the synaptic vesicle glycoprotein 2A gene (. SV2A) in schizophrenia susceptibility. To test systematically all common variants in the SV2A gene region for an association with schizophrenia, we used a HapMap-based haplotype tagging approach and tested five SNPs in 794 patients and 843 controls. The SNP rs15931 showed evidence for an association with schizophrenia and was followed-up in an independent sample of 2581 individuals (overall p-value. =. 0.0042, OR. =. 0.779). Our study in the German population provides evidence, at a genetic level, for the involvement of the SV2A gene region in schizophrenia.

AB - Convergent evidence from pharmacological and animal studies suggests a possible role for the synaptic vesicle glycoprotein 2A gene (. SV2A) in schizophrenia susceptibility. To test systematically all common variants in the SV2A gene region for an association with schizophrenia, we used a HapMap-based haplotype tagging approach and tested five SNPs in 794 patients and 843 controls. The SNP rs15931 showed evidence for an association with schizophrenia and was followed-up in an independent sample of 2581 individuals (overall p-value. =. 0.0042, OR. =. 0.779). Our study in the German population provides evidence, at a genetic level, for the involvement of the SV2A gene region in schizophrenia.

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Genetic variation at the synaptic vesicle gene SV2A is associated with schizophrenia

Resumen

Nota bibliográfica

ASJC Scopus Subject Areas

ODS de las Naciones Unidas

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