.Gut toxicity of 5-ASA?

D. J. Leddin, K. M. Peltekian

Research output: Contribution to journalArticlepeer-review

Abstract

The use of enteric coated 5-ASA is contraindicated in the presence of active peptic ulceration. The basis for this is unclear. The author wished to ensure that this drug was not toxic to the gastroduodenal mucosa before proceeding with a clinical trial of a suspension of 5-ASA in the treatment of proximal Crohn's disease. A review of the literature indicated that 5-ASA protects against ischemia/reperfusion-induced damage in the rat stomach but not against ethanol-induced injury. Studies in dogs indicated that 5-ASA does not cause gastric or duodenal damage. Similarly 5-ASA did not delay gastric ulcer healing in the rat and did not inhibit gastric tissue culture synthesis of prostaglandin E2. The current findings suggest that there is no contraindication to the use of 5-ASA in proximal Crohn's disease.

Original languageEnglish
Pages (from-to)170-172
Number of pages3
JournalCanadian Journal of Gastroenterology
Volume7
Issue number2
DOIs
Publication statusPublished - 1993
Externally publishedYes

ASJC Scopus Subject Areas

  • Gastroenterology

Fingerprint

Dive into the research topics of '.Gut toxicity of 5-ASA?'. Together they form a unique fingerprint.

Cite this