.Gut toxicity of 5-ASA?

D. J. Leddin, K. M. Peltekian

Producción científica: Contribución a una revistaArtículorevisión exhaustiva

Resumen

The use of enteric coated 5-ASA is contraindicated in the presence of active peptic ulceration. The basis for this is unclear. The author wished to ensure that this drug was not toxic to the gastroduodenal mucosa before proceeding with a clinical trial of a suspension of 5-ASA in the treatment of proximal Crohn's disease. A review of the literature indicated that 5-ASA protects against ischemia/reperfusion-induced damage in the rat stomach but not against ethanol-induced injury. Studies in dogs indicated that 5-ASA does not cause gastric or duodenal damage. Similarly 5-ASA did not delay gastric ulcer healing in the rat and did not inhibit gastric tissue culture synthesis of prostaglandin E2. The current findings suggest that there is no contraindication to the use of 5-ASA in proximal Crohn's disease.

Idioma originalEnglish
Páginas (desde-hasta)170-172
Número de páginas3
PublicaciónCanadian Journal of Gastroenterology
Volumen7
N.º2
DOI
EstadoPublished - 1993
Publicado de forma externa

ASJC Scopus Subject Areas

  • Gastroenterology

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