Abstract
Magnetic twisting cytometry (MTC) measures cellular mechanical properties, such as cell stiffness and viscosity, by applying mechanical stress to specific cell surface receptors via ligand-coated ferromagnetic beads. MTC measures simultaneously the rotation of approximately 50,000 beads attached to 20,000-40,000 cells. Here we show direct evidence of heterogeneous bead behavior and examine its consequences in the interpretation of cell mechanical properties.
| Original language | English |
|---|---|
| Pages (from-to) | 120-125 |
| Number of pages | 6 |
| Journal | Journal of Magnetism and Magnetic Materials |
| Volume | 194 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Apr 1999 |
| Externally published | Yes |
| Event | Proceedings of 1998 2nd International Conference on Scientific and Clinical Applications of Magnetic Carriers - Cleveland, OH, USA Duration: May 28 1998 → May 30 1998 |
Bibliographical note
Funding Information:We thank Tori Hatch for her invaluable help with scanning EM. Ning Wang has supplied the BCE cells and materials for MTC and helped us mastering the MTC technique. Rey Panettieri (University of Pennsylvania) has supplied the HASM cells. We thank In Lim, Johanne Laporte, Paul Moore and Jianxin Chen for technical assistance with the cell preparation. This work was supported by the Swiss National Foundation, Deutsche Forschungsgemeinschaft, NIH and NSERC Canada.
ASJC Scopus Subject Areas
- Electronic, Optical and Magnetic Materials
- Condensed Matter Physics