Inhibition of histamine death in pertussis-inoculated mice by Dibenzyline, an adrenergic blocking agent

Leon S. Kind

doi:10.1016/0021-8707(54)90046-5

Inhibition of histamine death in pertussis-inoculated mice by Dibenzyline, an adrenergic blocking agent

Leon S. Kind

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

The adrenergic blocking agent, Dibenzyline, inhibited the lethal effects of both histamine and epinephrine in pertussis-inoculated, histamine-sensitive mice. Protection against histamine was obtained with doses similar to those reported for Neoantergan. Mice injected with 25 mg./kg. of Dibenzyline were protected from 3 LD₅₀ of histamine administered twenty-four hours later.

Original language	English
Pages (from-to)	33-35
Number of pages	3
Journal	Journal of Allergy and Clinical Immunology
Volume	25
Issue number	1
DOIs	https://doi.org/10.1016/0021-8707(54)90046-5
Publication status	Published - Jan 1954
Externally published	Yes

Bibliographical note

Funding Information:
S. C., aided by a grant from the National Institutes of Health. Received for public&ion Aug. 10. 1953. *Supplied through the courtesy of the Smith, Kline & French Laboratories. ?Supplied through the courtesy of Sharp & Dohme, Inc.

ASJC Scopus Subject Areas

General Medicine

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10.1016/0021-8707(54)90046-5

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title = "Inhibition of histamine death in pertussis-inoculated mice by Dibenzyline, an adrenergic blocking agent",

abstract = "The adrenergic blocking agent, Dibenzyline, inhibited the lethal effects of both histamine and epinephrine in pertussis-inoculated, histamine-sensitive mice. Protection against histamine was obtained with doses similar to those reported for Neoantergan. Mice injected with 25 mg./kg. of Dibenzyline were protected from 3 LD50 of histamine administered twenty-four hours later.",

author = "Kind, {Leon S.}",

note = "Funding Information: S. C., aided by a grant from the National Institutes of Health. Received for public&ion Aug. 10. 1953. *Supplied through the courtesy of the Smith, Kline & French Laboratories. ?Supplied through the courtesy of Sharp & Dohme, Inc.",

year = "1954",

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doi = "10.1016/0021-8707(54)90046-5",

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AU - Kind, Leon S.

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PY - 1954/1

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N2 - The adrenergic blocking agent, Dibenzyline, inhibited the lethal effects of both histamine and epinephrine in pertussis-inoculated, histamine-sensitive mice. Protection against histamine was obtained with doses similar to those reported for Neoantergan. Mice injected with 25 mg./kg. of Dibenzyline were protected from 3 LD50 of histamine administered twenty-four hours later.

AB - The adrenergic blocking agent, Dibenzyline, inhibited the lethal effects of both histamine and epinephrine in pertussis-inoculated, histamine-sensitive mice. Protection against histamine was obtained with doses similar to those reported for Neoantergan. Mice injected with 25 mg./kg. of Dibenzyline were protected from 3 LD50 of histamine administered twenty-four hours later.

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Inhibition of histamine death in pertussis-inoculated mice by Dibenzyline, an adrenergic blocking agent

Abstract

Bibliographical note

ASJC Scopus Subject Areas

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