Inhibition of histamine death in pertussis-inoculated mice by Dibenzyline, an adrenergic blocking agent

Leon S. Kind

doi:10.1016/0021-8707(54)90046-5

Inhibition of histamine death in pertussis-inoculated mice by Dibenzyline, an adrenergic blocking agent

Leon S. Kind

Résultat de recherche: Article › examen par les pairs

3 Citations (Scopus)

Résumé

The adrenergic blocking agent, Dibenzyline, inhibited the lethal effects of both histamine and epinephrine in pertussis-inoculated, histamine-sensitive mice. Protection against histamine was obtained with doses similar to those reported for Neoantergan. Mice injected with 25 mg./kg. of Dibenzyline were protected from 3 LD₅₀ of histamine administered twenty-four hours later.

Langue d'origine	English
Pages (de-à)	33-35
Nombre de pages	3
Journal	Journal of Allergy and Clinical Immunology
Volume	25
Numéro de publication	1
DOI	https://doi.org/10.1016/0021-8707(54)90046-5
Statut de publication	Published - janv. 1954
Publié à l'externe	Oui

Note bibliographique

Funding Information:
S. C., aided by a grant from the National Institutes of Health. Received for public&ion Aug. 10. 1953. *Supplied through the courtesy of the Smith, Kline & French Laboratories. ?Supplied through the courtesy of Sharp & Dohme, Inc.

ASJC Scopus Subject Areas

General Medicine

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10.1016/0021-8707(54)90046-5

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abstract = "The adrenergic blocking agent, Dibenzyline, inhibited the lethal effects of both histamine and epinephrine in pertussis-inoculated, histamine-sensitive mice. Protection against histamine was obtained with doses similar to those reported for Neoantergan. Mice injected with 25 mg./kg. of Dibenzyline were protected from 3 LD50 of histamine administered twenty-four hours later.",

author = "Kind, {Leon S.}",

note = "Funding Information: S. C., aided by a grant from the National Institutes of Health. Received for public&ion Aug. 10. 1953. *Supplied through the courtesy of the Smith, Kline & French Laboratories. ?Supplied through the courtesy of Sharp & Dohme, Inc.",

year = "1954",

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doi = "10.1016/0021-8707(54)90046-5",

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AU - Kind, Leon S.

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PY - 1954/1

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N2 - The adrenergic blocking agent, Dibenzyline, inhibited the lethal effects of both histamine and epinephrine in pertussis-inoculated, histamine-sensitive mice. Protection against histamine was obtained with doses similar to those reported for Neoantergan. Mice injected with 25 mg./kg. of Dibenzyline were protected from 3 LD50 of histamine administered twenty-four hours later.

AB - The adrenergic blocking agent, Dibenzyline, inhibited the lethal effects of both histamine and epinephrine in pertussis-inoculated, histamine-sensitive mice. Protection against histamine was obtained with doses similar to those reported for Neoantergan. Mice injected with 25 mg./kg. of Dibenzyline were protected from 3 LD50 of histamine administered twenty-four hours later.

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Inhibition of histamine death in pertussis-inoculated mice by Dibenzyline, an adrenergic blocking agent

Résumé

Note bibliographique

ASJC Scopus Subject Areas

Accès au document

Autres fichiers et liens

Empreinte numérique

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