Intermediate filaments: From cell architecture to nanomechanics

Harald Herrmann; Harald Bär; Laurent Kreplak; Sergei V. Strelkov; Ueli Aebi

doi:10.1038/nrm2197

Intermediate filaments: From cell architecture to nanomechanics

Harald Herrmann, Harald Bär, Laurent Kreplak, Sergei V. Strelkov, Ueli Aebi

Research output: Contribution to journal › Review article › peer-review

547 Citations (Scopus)

Abstract

Intermediate filaments (IFs) constitute a major structural element of animal cells. They build two distinct systems, one in the nucleus and one in the cytoplasm. In both cases, their major function is assumed to be that of a mechanical stress absorber and an integrating device for the entire cytoskeleton. In line with this, recent disease mutations in human IF proteins indicate that the nanomechanical properties of cell-type-specific IFs are central to the pathogenesis of diseases as diverse as muscular dystrophy and premature ageing. However, the analysis of these various diseases suggests that IFs also have an important role in cell-type-specific physiological functions.

Original language	English
Pages (from-to)	562-573
Number of pages	12
Journal	Nature Reviews Molecular Cell Biology
Volume	8
Issue number	7
DOIs	https://doi.org/10.1038/nrm2197
Publication status	Published - Jul 2007
Externally published	Yes

Bibliographical note

Funding Information:
The authors wish to acknowledge support from the German Research Foundation (H.H. and H.B.), the Swiss Society for Research on Muscular Diseases (U.A. and S.V.S.), the National Centre of Competence in Research program on ‘Nanoscale Science’, the Swiss National Science Foundation, the M.E. Müller Foundation of Switzerland and the Canton Basel-Stadt (all to U.A.), Group Biomedical Sciences and the Research Council of the Catholic University of Leuven (S.V.S.) and the European Union FP6 Life Science, Genomics and Biotechnology for Health area (H.H. and U.A.).

ASJC Scopus Subject Areas

Molecular Biology
Cell Biology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1038/nrm2197

Cite this

Herrmann, H., Bär, H., Kreplak, L., Strelkov, S. V., & Aebi, U. (2007). Intermediate filaments: From cell architecture to nanomechanics. Nature Reviews Molecular Cell Biology, 8(7), 562-573. https://doi.org/10.1038/nrm2197

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title = "Intermediate filaments: From cell architecture to nanomechanics",

abstract = "Intermediate filaments (IFs) constitute a major structural element of animal cells. They build two distinct systems, one in the nucleus and one in the cytoplasm. In both cases, their major function is assumed to be that of a mechanical stress absorber and an integrating device for the entire cytoskeleton. In line with this, recent disease mutations in human IF proteins indicate that the nanomechanical properties of cell-type-specific IFs are central to the pathogenesis of diseases as diverse as muscular dystrophy and premature ageing. However, the analysis of these various diseases suggests that IFs also have an important role in cell-type-specific physiological functions.",

author = "Harald Herrmann and Harald B{\"a}r and Laurent Kreplak and Strelkov, {Sergei V.} and Ueli Aebi",

note = "Funding Information: The authors wish to acknowledge support from the German Research Foundation (H.H. and H.B.), the Swiss Society for Research on Muscular Diseases (U.A. and S.V.S.), the National Centre of Competence in Research program on {\textquoteleft}Nanoscale Science{\textquoteright}, the Swiss National Science Foundation, the M.E. M{\"u}ller Foundation of Switzerland and the Canton Basel-Stadt (all to U.A.), Group Biomedical Sciences and the Research Council of the Catholic University of Leuven (S.V.S.) and the European Union FP6 Life Science, Genomics and Biotechnology for Health area (H.H. and U.A.).",

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AU - Aebi, Ueli

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Intermediate filaments: From cell architecture to nanomechanics

Abstract

Bibliographical note

ASJC Scopus Subject Areas

UN SDGs

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