Intermediate filaments: From cell architecture to nanomechanics

Harald Herrmann; Harald Bär; Laurent Kreplak; Sergei V. Strelkov; Ueli Aebi

doi:10.1038/nrm2197

Intermediate filaments: From cell architecture to nanomechanics

Harald Herrmann, Harald Bär, Laurent Kreplak, Sergei V. Strelkov, Ueli Aebi

Producción científica: Contribución a una revista › Artículo de revisión › revisión exhaustiva

547 Citas (Scopus)

Resumen

Intermediate filaments (IFs) constitute a major structural element of animal cells. They build two distinct systems, one in the nucleus and one in the cytoplasm. In both cases, their major function is assumed to be that of a mechanical stress absorber and an integrating device for the entire cytoskeleton. In line with this, recent disease mutations in human IF proteins indicate that the nanomechanical properties of cell-type-specific IFs are central to the pathogenesis of diseases as diverse as muscular dystrophy and premature ageing. However, the analysis of these various diseases suggests that IFs also have an important role in cell-type-specific physiological functions.

Idioma original	English
Páginas (desde-hasta)	562-573
Número de páginas	12
Publicación	Nature Reviews Molecular Cell Biology
Volumen	8
N.º	7
DOI	https://doi.org/10.1038/nrm2197
Estado	Published - jul. 2007
Publicado de forma externa	Sí

Nota bibliográfica

Funding Information:
The authors wish to acknowledge support from the German Research Foundation (H.H. and H.B.), the Swiss Society for Research on Muscular Diseases (U.A. and S.V.S.), the National Centre of Competence in Research program on ‘Nanoscale Science’, the Swiss National Science Foundation, the M.E. Müller Foundation of Switzerland and the Canton Basel-Stadt (all to U.A.), Group Biomedical Sciences and the Research Council of the Catholic University of Leuven (S.V.S.) and the European Union FP6 Life Science, Genomics and Biotechnology for Health area (H.H. and U.A.).

ASJC Scopus Subject Areas

Molecular Biology
Cell Biology

ODS de las Naciones Unidas

Este resultado contribuye a los siguientes Objetivos de Desarrollo Sostenible

Acceder al documento

10.1038/nrm2197

Otros archivos y enlaces

Citar esto

@article{af726993204d4c97947c0529d740ea99,

title = "Intermediate filaments: From cell architecture to nanomechanics",

abstract = "Intermediate filaments (IFs) constitute a major structural element of animal cells. They build two distinct systems, one in the nucleus and one in the cytoplasm. In both cases, their major function is assumed to be that of a mechanical stress absorber and an integrating device for the entire cytoskeleton. In line with this, recent disease mutations in human IF proteins indicate that the nanomechanical properties of cell-type-specific IFs are central to the pathogenesis of diseases as diverse as muscular dystrophy and premature ageing. However, the analysis of these various diseases suggests that IFs also have an important role in cell-type-specific physiological functions.",

author = "Harald Herrmann and Harald B{\"a}r and Laurent Kreplak and Strelkov, {Sergei V.} and Ueli Aebi",

note = "Funding Information: The authors wish to acknowledge support from the German Research Foundation (H.H. and H.B.), the Swiss Society for Research on Muscular Diseases (U.A. and S.V.S.), the National Centre of Competence in Research program on {\textquoteleft}Nanoscale Science{\textquoteright}, the Swiss National Science Foundation, the M.E. M{\"u}ller Foundation of Switzerland and the Canton Basel-Stadt (all to U.A.), Group Biomedical Sciences and the Research Council of the Catholic University of Leuven (S.V.S.) and the European Union FP6 Life Science, Genomics and Biotechnology for Health area (H.H. and U.A.).",

year = "2007",

month = jul,

doi = "10.1038/nrm2197",

language = "English",

volume = "8",

pages = "562--573",

journal = "Nature Reviews Molecular Cell Biology",

issn = "1471-0072",

publisher = "Nature Publishing Group",

number = "7",

}

TY - JOUR

T1 - Intermediate filaments

T2 - From cell architecture to nanomechanics

AU - Herrmann, Harald

AU - Bär, Harald

AU - Kreplak, Laurent

AU - Strelkov, Sergei V.

AU - Aebi, Ueli

N1 - Funding Information: The authors wish to acknowledge support from the German Research Foundation (H.H. and H.B.), the Swiss Society for Research on Muscular Diseases (U.A. and S.V.S.), the National Centre of Competence in Research program on ‘Nanoscale Science’, the Swiss National Science Foundation, the M.E. Müller Foundation of Switzerland and the Canton Basel-Stadt (all to U.A.), Group Biomedical Sciences and the Research Council of the Catholic University of Leuven (S.V.S.) and the European Union FP6 Life Science, Genomics and Biotechnology for Health area (H.H. and U.A.).

PY - 2007/7

Y1 - 2007/7

N2 - Intermediate filaments (IFs) constitute a major structural element of animal cells. They build two distinct systems, one in the nucleus and one in the cytoplasm. In both cases, their major function is assumed to be that of a mechanical stress absorber and an integrating device for the entire cytoskeleton. In line with this, recent disease mutations in human IF proteins indicate that the nanomechanical properties of cell-type-specific IFs are central to the pathogenesis of diseases as diverse as muscular dystrophy and premature ageing. However, the analysis of these various diseases suggests that IFs also have an important role in cell-type-specific physiological functions.

AB - Intermediate filaments (IFs) constitute a major structural element of animal cells. They build two distinct systems, one in the nucleus and one in the cytoplasm. In both cases, their major function is assumed to be that of a mechanical stress absorber and an integrating device for the entire cytoskeleton. In line with this, recent disease mutations in human IF proteins indicate that the nanomechanical properties of cell-type-specific IFs are central to the pathogenesis of diseases as diverse as muscular dystrophy and premature ageing. However, the analysis of these various diseases suggests that IFs also have an important role in cell-type-specific physiological functions.

UR - http://www.scopus.com/inward/record.url?scp=34250880140&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34250880140&partnerID=8YFLogxK

U2 - 10.1038/nrm2197

DO - 10.1038/nrm2197

M3 - Review article

C2 - 17551517

AN - SCOPUS:34250880140

SN - 1471-0072

VL - 8

SP - 562

EP - 573

JO - Nature Reviews Molecular Cell Biology

JF - Nature Reviews Molecular Cell Biology

IS - 7

ER -

Intermediate filaments: From cell architecture to nanomechanics

Resumen

Nota bibliográfica

ASJC Scopus Subject Areas

ODS de las Naciones Unidas

Acceder al documento

Otros archivos y enlaces

Huella

Citar esto