Iron chelation for the treatment of uveitis

Junru Chen; Juan Zhou; Mel Kelly; Bruce E. Holbein; Christian Lehmann

doi:10.1016/j.mehy.2017.03.029

Iron chelation for the treatment of uveitis

Junru Chen, Juan Zhou, Mel Kelly, Bruce E. Holbein, Christian Lehmann

Medicine

Medicine

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

Inflammatory eye diseases such as uveitis are common and may eventually result in vision loss. Iron can play a critical role in ocular inflammation via promoting the generation of oxygen free radicals and it is also nutritionally essential for microbial growth. Considering this involvement of iron in inflammation and microbial infection, we hypothesize that administration of iron chelators has potential to function as a novel therapy in uveitis and help improve clinical outcomes.

Original language	English
Pages (from-to)	1-4
Number of pages	4
Journal	Medical Hypotheses
Volume	103
DOIs	https://doi.org/10.1016/j.mehy.2017.03.029
Publication status	Published - Jun 1 2017

Bibliographical note

Publisher Copyright:
© 2017 Elsevier Ltd

ASJC Scopus Subject Areas

General Medicine

PubMed: MeSH publication types

Journal Article

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10.1016/j.mehy.2017.03.029

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abstract = "Inflammatory eye diseases such as uveitis are common and may eventually result in vision loss. Iron can play a critical role in ocular inflammation via promoting the generation of oxygen free radicals and it is also nutritionally essential for microbial growth. Considering this involvement of iron in inflammation and microbial infection, we hypothesize that administration of iron chelators has potential to function as a novel therapy in uveitis and help improve clinical outcomes.",

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AU - Zhou, Juan

AU - Kelly, Mel

AU - Holbein, Bruce E.

AU - Lehmann, Christian

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AB - Inflammatory eye diseases such as uveitis are common and may eventually result in vision loss. Iron can play a critical role in ocular inflammation via promoting the generation of oxygen free radicals and it is also nutritionally essential for microbial growth. Considering this involvement of iron in inflammation and microbial infection, we hypothesize that administration of iron chelators has potential to function as a novel therapy in uveitis and help improve clinical outcomes.

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Iron chelation for the treatment of uveitis

Abstract

Bibliographical note

ASJC Scopus Subject Areas

PubMed: MeSH publication types

Access to Document

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