Lack of effect of 6-hydroxydopamine pretreatment on depolarization-induced release of ATP from rat brain synaptosomes

Pamela E. Potter; Thomas D. White

doi:10.1016/0014-2999(82)90191-1

Lack of effect of 6-hydroxydopamine pretreatment on depolarization-induced release of ATP from rat brain synaptosomes

Pamela E. Potter, Thomas D. White

Medicine

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Abstract

Pretreatment of rats with intraventricular 6-hydroxydopamine produced considerable destruction of noradrenergic and dopaminergic nerve terminals as indicated by depletions in synaptosomal catecholamine contents. However, 6-hydroxydopamine pretreatment did not result in diminished release of ATP during depolarization of synaptosomes with either elevated extracellular K⁺ or veratridine. These findings suggest that most of the ATP released during the depolarization of rat brain synaptosomal preparations is not co-released with noradrenaline or dopamine but must originate from other sources.

Original language	English
Pages (from-to)	143-147
Number of pages	5
Journal	European Journal of Pharmacology
Volume	80
Issue number	1
DOIs	https://doi.org/10.1016/0014-2999(82)90191-1
Publication status	Published - May 7 1982

Bibliographical note

Funding Information:
The authors thank H.A. Robertson for providing the methods for determining noradrenaline and dopamine and Diana Webb for her expert technical assistance. This study was supported by a grant from the Medical Research Council of Canada.

ASJC Scopus Subject Areas

Pharmacology

Access to Document

10.1016/0014-2999(82)90191-1

Cite this

@article{f16d5dd63fdf4b5ca9ece32c0bf4d2f4,

title = "Lack of effect of 6-hydroxydopamine pretreatment on depolarization-induced release of ATP from rat brain synaptosomes",

abstract = "Pretreatment of rats with intraventricular 6-hydroxydopamine produced considerable destruction of noradrenergic and dopaminergic nerve terminals as indicated by depletions in synaptosomal catecholamine contents. However, 6-hydroxydopamine pretreatment did not result in diminished release of ATP during depolarization of synaptosomes with either elevated extracellular K+ or veratridine. These findings suggest that most of the ATP released during the depolarization of rat brain synaptosomal preparations is not co-released with noradrenaline or dopamine but must originate from other sources.",

author = "Potter, {Pamela E.} and White, {Thomas D.}",

note = "Funding Information: The authors thank H.A. Robertson for providing the methods for determining noradrenaline and dopamine and Diana Webb for her expert technical assistance. This study was supported by a grant from the Medical Research Council of Canada.",

year = "1982",

month = may,

day = "7",

doi = "10.1016/0014-2999(82)90191-1",

language = "English",

volume = "80",

pages = "143--147",

journal = "European Journal of Pharmacology",

issn = "0014-2999",

publisher = "Elsevier",

number = "1",

}

TY - JOUR

T1 - Lack of effect of 6-hydroxydopamine pretreatment on depolarization-induced release of ATP from rat brain synaptosomes

AU - Potter, Pamela E.

AU - White, Thomas D.

N1 - Funding Information: The authors thank H.A. Robertson for providing the methods for determining noradrenaline and dopamine and Diana Webb for her expert technical assistance. This study was supported by a grant from the Medical Research Council of Canada.

PY - 1982/5/7

Y1 - 1982/5/7

N2 - Pretreatment of rats with intraventricular 6-hydroxydopamine produced considerable destruction of noradrenergic and dopaminergic nerve terminals as indicated by depletions in synaptosomal catecholamine contents. However, 6-hydroxydopamine pretreatment did not result in diminished release of ATP during depolarization of synaptosomes with either elevated extracellular K+ or veratridine. These findings suggest that most of the ATP released during the depolarization of rat brain synaptosomal preparations is not co-released with noradrenaline or dopamine but must originate from other sources.

AB - Pretreatment of rats with intraventricular 6-hydroxydopamine produced considerable destruction of noradrenergic and dopaminergic nerve terminals as indicated by depletions in synaptosomal catecholamine contents. However, 6-hydroxydopamine pretreatment did not result in diminished release of ATP during depolarization of synaptosomes with either elevated extracellular K+ or veratridine. These findings suggest that most of the ATP released during the depolarization of rat brain synaptosomal preparations is not co-released with noradrenaline or dopamine but must originate from other sources.

UR - http://www.scopus.com/inward/record.url?scp=0020075906&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0020075906&partnerID=8YFLogxK

U2 - 10.1016/0014-2999(82)90191-1

DO - 10.1016/0014-2999(82)90191-1

M3 - Article

C2 - 7095000

AN - SCOPUS:0020075906

SN - 0014-2999

VL - 80

SP - 143

EP - 147

JO - European Journal of Pharmacology

JF - European Journal of Pharmacology

IS - 1

ER -

Lack of effect of 6-hydroxydopamine pretreatment on depolarization-induced release of ATP from rat brain synaptosomes

Abstract

Bibliographical note

ASJC Scopus Subject Areas

Access to Document

Other files and links

Fingerprint

Cite this