Lack of effect of 6-hydroxydopamine pretreatment on depolarization-induced release of ATP from rat brain synaptosomes

Pamela E. Potter; Thomas D. White

doi:10.1016/0014-2999(82)90191-1

Lack of effect of 6-hydroxydopamine pretreatment on depolarization-induced release of ATP from rat brain synaptosomes

Pamela E. Potter, Thomas D. White

Medicine

Producción científica: Contribución a una revista › Artículo › revisión exhaustiva

10 Citas (Scopus)

Resumen

Pretreatment of rats with intraventricular 6-hydroxydopamine produced considerable destruction of noradrenergic and dopaminergic nerve terminals as indicated by depletions in synaptosomal catecholamine contents. However, 6-hydroxydopamine pretreatment did not result in diminished release of ATP during depolarization of synaptosomes with either elevated extracellular K⁺ or veratridine. These findings suggest that most of the ATP released during the depolarization of rat brain synaptosomal preparations is not co-released with noradrenaline or dopamine but must originate from other sources.

Idioma original	English
Páginas (desde-hasta)	143-147
Número de páginas	5
Publicación	European Journal of Pharmacology
Volumen	80
N.º	1
DOI	https://doi.org/10.1016/0014-2999(82)90191-1
Estado	Published - may. 7 1982

Nota bibliográfica

Funding Information:
The authors thank H.A. Robertson for providing the methods for determining noradrenaline and dopamine and Diana Webb for her expert technical assistance. This study was supported by a grant from the Medical Research Council of Canada.

ASJC Scopus Subject Areas

Pharmacology

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10.1016/0014-2999(82)90191-1

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abstract = "Pretreatment of rats with intraventricular 6-hydroxydopamine produced considerable destruction of noradrenergic and dopaminergic nerve terminals as indicated by depletions in synaptosomal catecholamine contents. However, 6-hydroxydopamine pretreatment did not result in diminished release of ATP during depolarization of synaptosomes with either elevated extracellular K+ or veratridine. These findings suggest that most of the ATP released during the depolarization of rat brain synaptosomal preparations is not co-released with noradrenaline or dopamine but must originate from other sources.",

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AU - White, Thomas D.

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Y1 - 1982/5/7

N2 - Pretreatment of rats with intraventricular 6-hydroxydopamine produced considerable destruction of noradrenergic and dopaminergic nerve terminals as indicated by depletions in synaptosomal catecholamine contents. However, 6-hydroxydopamine pretreatment did not result in diminished release of ATP during depolarization of synaptosomes with either elevated extracellular K+ or veratridine. These findings suggest that most of the ATP released during the depolarization of rat brain synaptosomal preparations is not co-released with noradrenaline or dopamine but must originate from other sources.

AB - Pretreatment of rats with intraventricular 6-hydroxydopamine produced considerable destruction of noradrenergic and dopaminergic nerve terminals as indicated by depletions in synaptosomal catecholamine contents. However, 6-hydroxydopamine pretreatment did not result in diminished release of ATP during depolarization of synaptosomes with either elevated extracellular K+ or veratridine. These findings suggest that most of the ATP released during the depolarization of rat brain synaptosomal preparations is not co-released with noradrenaline or dopamine but must originate from other sources.

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Lack of effect of 6-hydroxydopamine pretreatment on depolarization-induced release of ATP from rat brain synaptosomes

Resumen

Nota bibliográfica

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