Long-range, wide-field swept-source optical coherence tomography with GPU accelerated digital lock-in Doppler vibrography for real-time, in vivo middle ear diagnostics

Dan MacDougall; Joshua Farrell; Jeremy Brown; Manohar Bance; Robert Adamson

doi:10.1364/BOE.7.004621

Long-range, wide-field swept-source optical coherence tomography with GPU accelerated digital lock-in Doppler vibrography for real-time, in vivo middle ear diagnostics

Dan MacDougall, Joshua Farrell, Jeremy Brown, Manohar Bance, Robert Adamson

Medicine

Research output: Contribution to journal › Article › peer-review

55 Citations (Scopus)

Abstract

We present the design, implementation and validation of a swept-source optical coherence tomography (OCT) system for real-time imaging of the human middle ear in live patients. Our system consists of a highly phase-stable Vernier-tuned distributed Bragg-reflector laser along with a real-time processing engine implemented on a graphics processing unit. We use the system to demonstrate, for the first time in live subjects, real-time Doppler measurements of middle ear vibration in response to sound, video rate 2D B-mode imaging of the middle ear and 3D volumetric B-mode imaging. All measurements were performed non-invasively through the intact tympanic membrane demonstrating that the technology is readily translatable to the clinic.

Original language	English
Article number	#268551
Pages (from-to)	4621-4635
Number of pages	15
Journal	Biomedical Optics Express
Volume	7
Issue number	11
DOIs	https://doi.org/10.1364/BOE.7.004621
Publication status	Published - Nov 1 2016

Bibliographical note

Funding Information:
This work was supported through grants from the Natural Sciences and Engineering Research Council of Canada, the Atlantic Canada Opportunities Agency, Springboard Atlantic and Innovacorp.

Publisher Copyright:
© 2016 Optical Society of America.

ASJC Scopus Subject Areas

Biotechnology
Atomic and Molecular Physics, and Optics

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10.1364/BOE.7.004621

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Long-range, wide-field swept-source optical coherence tomography with GPU accelerated digital lock-in Doppler vibrography for real-time, in vivo middle ear diagnostics. / MacDougall, Dan; Farrell, Joshua; Brown, Jeremy et al.
In: Biomedical Optics Express, Vol. 7, No. 11, #268551, 01.11.2016, p. 4621-4635.

Research output: Contribution to journal › Article › peer-review

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Long-range, wide-field swept-source optical coherence tomography with GPU accelerated digital lock-in Doppler vibrography for real-time, in vivo middle ear diagnostics

Abstract

Bibliographical note

ASJC Scopus Subject Areas

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