Long-range, wide-field swept-source optical coherence tomography with GPU accelerated digital lock-in Doppler vibrography for real-time, in vivo middle ear diagnostics

Dan MacDougall, Joshua Farrell, Jeremy Brown, Manohar Bance, Robert Adamson

Producción científica: Contribución a una revistaArtículorevisión exhaustiva

55 Citas (Scopus)

Resumen

We present the design, implementation and validation of a swept-source optical coherence tomography (OCT) system for real-time imaging of the human middle ear in live patients. Our system consists of a highly phase-stable Vernier-tuned distributed Bragg-reflector laser along with a real-time processing engine implemented on a graphics processing unit. We use the system to demonstrate, for the first time in live subjects, real-time Doppler measurements of middle ear vibration in response to sound, video rate 2D B-mode imaging of the middle ear and 3D volumetric B-mode imaging. All measurements were performed non-invasively through the intact tympanic membrane demonstrating that the technology is readily translatable to the clinic.

Idioma originalEnglish
Número de artículo#268551
Páginas (desde-hasta)4621-4635
Número de páginas15
PublicaciónBiomedical Optics Express
Volumen7
N.º11
DOI
EstadoPublished - nov. 1 2016

Nota bibliográfica

Funding Information:
This work was supported through grants from the Natural Sciences and Engineering Research Council of Canada, the Atlantic Canada Opportunities Agency, Springboard Atlantic and Innovacorp.

Publisher Copyright:
© 2016 Optical Society of America.

ASJC Scopus Subject Areas

  • Biotechnology
  • Atomic and Molecular Physics, and Optics

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