Abstract
The mechanistic target of rapamycin (mTOR) is an evolutionarily conserved serine/threonine kinase that senses and integrates environmental information into cellular regulation and homeostasis. Accumulating evidence has suggested a master role of mTOR signalling in many fundamental aspects of cell biology and organismal development. mTOR deregulation is implicated in a broad range of pathological conditions, including diabetes, cancer, neurodegenerative diseases, myopathies, inflammatory, infectious, and autoimmune conditions. Here, we review recent advances in our knowledge of mTOR signalling in mammalian physiology. We also discuss the impact of mTOR alteration in human diseases and how targeting mTOR function can treat human diseases.
| Original language | English |
|---|---|
| Pages (from-to) | 58-67 |
| Number of pages | 10 |
| Journal | Biochemistry and Cell Biology |
| Volume | 97 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 2019 |
Bibliographical note
Funding Information:This work was supported by start-up funds to Y.E.H. and X.D. from the Department of Physiology and Biophysics, Dalhousie University. We appreciate the encouragement and helpful comments from Peter Kim, Department of Biochemistry, University of Toronto.
Publisher Copyright:
© 2019 Published by NRC Research Press.
ASJC Scopus Subject Areas
- Biochemistry
- Molecular Biology
- Cell Biology
