MTOR signalling: Jack-of-all-trades

Yassine El Hiani; Emmanuel Eroume A. Egom; Xian Ping Dong

doi:10.1139/bcb-2018-0004

MTOR signalling: Jack-of-all-trades

Yassine El Hiani, Emmanuel Eroume A. Egom, Xian Ping Dong

Producción científica: Contribución a una revista › Artículo de revisión › revisión exhaustiva

24 Citas (Scopus)

Resumen

The mechanistic target of rapamycin (mTOR) is an evolutionarily conserved serine/threonine kinase that senses and integrates environmental information into cellular regulation and homeostasis. Accumulating evidence has suggested a master role of mTOR signalling in many fundamental aspects of cell biology and organismal development. mTOR deregulation is implicated in a broad range of pathological conditions, including diabetes, cancer, neurodegenerative diseases, myopathies, inflammatory, infectious, and autoimmune conditions. Here, we review recent advances in our knowledge of mTOR signalling in mammalian physiology. We also discuss the impact of mTOR alteration in human diseases and how targeting mTOR function can treat human diseases.

Idioma original	English
Páginas (desde-hasta)	58-67
Número de páginas	10
Publicación	Biochemistry and Cell Biology
Volumen	97
N.º	1
DOI	https://doi.org/10.1139/bcb-2018-0004
Estado	Published - 2019

Nota bibliográfica

Funding Information:
This work was supported by start-up funds to Y.E.H. and X.D. from the Department of Physiology and Biophysics, Dalhousie University. We appreciate the encouragement and helpful comments from Peter Kim, Department of Biochemistry, University of Toronto.

Publisher Copyright:
© 2019 Published by NRC Research Press.

ASJC Scopus Subject Areas

Biochemistry
Molecular Biology
Cell Biology

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abstract = "The mechanistic target of rapamycin (mTOR) is an evolutionarily conserved serine/threonine kinase that senses and integrates environmental information into cellular regulation and homeostasis. Accumulating evidence has suggested a master role of mTOR signalling in many fundamental aspects of cell biology and organismal development. mTOR deregulation is implicated in a broad range of pathological conditions, including diabetes, cancer, neurodegenerative diseases, myopathies, inflammatory, infectious, and autoimmune conditions. Here, we review recent advances in our knowledge of mTOR signalling in mammalian physiology. We also discuss the impact of mTOR alteration in human diseases and how targeting mTOR function can treat human diseases.",

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AU - El Hiani, Yassine

AU - Egom, Emmanuel Eroume A.

AU - Dong, Xian Ping

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N2 - The mechanistic target of rapamycin (mTOR) is an evolutionarily conserved serine/threonine kinase that senses and integrates environmental information into cellular regulation and homeostasis. Accumulating evidence has suggested a master role of mTOR signalling in many fundamental aspects of cell biology and organismal development. mTOR deregulation is implicated in a broad range of pathological conditions, including diabetes, cancer, neurodegenerative diseases, myopathies, inflammatory, infectious, and autoimmune conditions. Here, we review recent advances in our knowledge of mTOR signalling in mammalian physiology. We also discuss the impact of mTOR alteration in human diseases and how targeting mTOR function can treat human diseases.

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MTOR signalling: Jack-of-all-trades

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Nota bibliográfica

ASJC Scopus Subject Areas

ODS de las Naciones Unidas

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